Abstract:
OBJECTIVE:To examine whether selected genetic polymorphisms in the infant are associated with spontaneous preterm birth (less than 37 weeks) among children with or without later-diagnosed cerebral palsy. METHODS:Exploratory case-control study investigating the relationship of gestational age at delivery to 31 single nucleotide polymorphisms measured in newborn screening bloodspots. Among all 443 children with later-diagnosed cerebral palsy born to white women in South Australia in 1986-1999, 234 were born after spontaneous onset of labor, and 108 of these were preterm (gestational age less than 37 weeks). The comparison group was 549 infants born after spontaneous onset of labor, of whom 147 were preterm. Distributions of genotypic frequencies were examined in preterm compared with term infants with and without cerebral palsy. Genotyping was performed using a Taqman assay. RESULTS:In children without cerebral palsy, preterm birth after spontaneous onset of labor was more frequent in association with a variant of the beta2 adrenergic receptor gene (ADRB2 Q27E, P=.003), inducible nitric oxide synthase (iNOS or NOS2A, P=.042), or thrombomodulin (G127A, P=.006). Among children with cerebral palsy, preterm birth was associated with polymorphisms in genes for endothelial nitric oxide synthase (eNOS -922, P=.012), plasminogen activator inhibitor-2 (P=.015 and .019), and alpha adducin (ADD1, P=.047). CONCLUSION:We confirm previous observations that variants of the beta adrenergic receptor and of nitric oxide synthase are associated with prematurity, and suggest that genetic variants of the placental antifibrinolytic plasminogen activator inhibitor-2, and thrombomodulin and alpha adducin may be contributors to risk of spontaneous preterm birth. LEVEL OF EVIDENCE:II.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Gibson CS,MacLennan AH,Dekker GA,Goldwater PN,Dambrosia JM,Munroe DJ,Tsang S,Stewart C,Nelson KBdoi
10.1097/01.AOG.0000252712.62241.1asubject
Has Abstractpub_date
2007-02-01 00:00:00pages
384-91issue
2 Pt 1eissn
0029-7844issn
1873-233Xpii
109/2/384journal_volume
109pub_type
杂志文章abstract::The recently developed sperm penetration assay (SPA) tests the functional capacity of sperm. It is based upon the ability of in vitro capacitated human spermatozoa to penetrate zona-free hamster eggs in vitro. The SPA was superior to seminal fluid analysis in predicting both fertility and infertility; in the predictio...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::Physician wellness directly affects patient and physician health and has broader implications for our health systems. A summary of what is known about physician wellness in medicine, and obstetrics and gynecology in particular, identifies several areas for future focus. To change our culture and the structure of our a...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002328
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Only one case of plasma cell cervicitis, a rare variant of chronic cervicitis, has been reported. We report a second case and present data supporting the detection of human papillomavirus (HPV) outside of epithelial tissues. CASE:A 67-year-old woman was found to have a large cervical tumor. Extensive diagno...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::A cytogenetic study of 27 spontaneous abortions was carried out using the Q-banding technic. The specimens were selected for study in order to increase the likelihood of finding a chromosome anomaly. Sixteen of 27 specimens (59%) showed a chromosome abnormality. Trisomy was found in 9 of the specimens, and the chromos...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVE:To evaluate maternal parity, the sonographic measurement of cervical length, and the five components of the Bishop score to determine which factors best predict the length of latent-phase labor in women undergoing labor induction. METHODS:Cervical position, cervical consistency, cervical effacement, cervical...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(96)00321-3
更新日期:1996-12-01 00:00:00
abstract::Fertility and pregnancy complications were assessed in 137 women at risk of having inherited the gene for autosomal dominant polycystic kidney disease. Seventy-six (55%) of these subjects were found to have polycystic kidney disease (multiple renal cysts). The remaining 61 women served as controls. The prevalence of f...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::Arteriovenous fistulae of the ovarian artery may develop after gynecologic surgery. A case that occurred 9 years after hysterectomy with bilateral oophorectomy is presented and discussed. It illustrates an unusual cause of left lower quadrant abdominal pain. Surgical removal of the ovarian arteriovenous fistula result...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:To quantify the numbers of leukocytes in the normal cervix and relate these numbers to the diagnosis of cervicitis. METHODS:Isolated cell suspensions were prepared from cervical tissue recovered at hysterectomy from 37 women who had no obvious cervical disease. The percentages of CD45+ cells (leukocytes) in ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(98)00086-6
更新日期:1998-06-01 00:00:00
abstract::The intrapartum management of pregnancy complicated by fetal hydrocephalus with macrocephaly often confronts the physician with a complex array of moral obligations to both mother and fetus that may sometimes come into direct conflict. The authors analyze the component beneficence-based and autonomy-based obligations ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:To calculate pooled risk estimates for combinations of cytology result, human papillomavirus (HPV) 16/18 genotype and colposcopy impression to provide a basis for risk-stratified colposcopy and biopsy practice. DATA SOURCE:A PubMed search was conducted on June 1, 2016, and a ClinicalTrials.gov search was con...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,meta分析
doi:10.1097/AOG.0000000000002812
更新日期:2018-09-01 00:00:00
abstract::The overwhelming majority of morbidity and mortality attributable to pertussis infection occurs in infants who are 3 months and younger. Infants do not begin their own vaccine series against pertussis until approximately 2 months of age. This leaves a window of significant vulnerability for newborns, many of whom cont...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,实务指引
doi:10.1097/AOG.0000000000002293
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries. METHODS:We conducted a prospective multicenter observational study of women with prior cesarean delivery undergoing trial of labor and elective repeat operation. Maternal and p...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,多中心研究
doi:10.1097/01.AOG.0000224694.32531.f3
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To estimate the incidence of occult uterine sarcoma and leiomyosarcoma in hysterectomies for leiomyomas and the risk associated with their morcellation. METHODS:We conducted a population-based cohort study. All uterine sarcomas from 2006-2013 in an integrated health care system were identified. Age- and race...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000001187
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To compare the prevalence of large-for-gestational-age (LGA) newborns across categories of body mass index (BMI) in five racial and ethnic groups. METHODS:This cohort study examined 7,468 women with gestational diabetes mellitus (GDM) who delivered a live newborn between 1995 and 2006 at Kaiser Permanente No...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e318291b15c
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Umbilical vascular coiling may function as a rudimentary pump that facilitates venous return from the placenta. CASES:Three consecutive twin gestations with twin-twin transfusion syndrome were evaluated prospectively at delivery. The birth weights and umbilical coiling indices of donor and recipient twins w...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(97)00057-4
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Anaphylactoid syndrome of pregnancy is a rare and poorly understood complication of pregnancy. Intrauterine pressure catheter placement is a procedure routinely performed in labor and delivery that is traditionally associated with few complications. CASE:A pregnant woman at term experienced anaphylactoid sy...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181b5c8cc
更新日期:2010-02-01 00:00:00
abstract::Slips of the tongue are common and often amusing phonic errors. Although surely not the first speaker to make such transpositions, W.A. Spooner (1844-1930) was well known for them and was the source of the eponym, "Spoonerism." Several of his noted slips are presented along with a whimsical obstetric presentation. ...
journal_title:Obstetrics and gynecology
pub_type: 传,历史文章,杂志文章
doi:10.1016/s0029-7844(97)00146-4
更新日期:1997-06-01 00:00:00
abstract::Apgar scores are used routinely to assess early neonatal status, but are less accurate in the preterm neonate because of developmental immaturity. Attention has been directed to umbilical cord gases as a method of neonatal evaluation. Using a retrospective chart review of all viable preterm births (24-36 weeks' gestat...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:To estimate whether the risk of recurrent preeclampsia is affected by interpregnancy change in body mass index (BMI). METHODS:We conducted a population-based cohort study using Missouri maternally linked birth certificates for 17,773 women whose first pregnancies were complicated by preeclampsia. The women w...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181ed74ea
更新日期:2010-09-01 00:00:00
abstract::Cervical smears taken by the wooden Ayre spatula (widely used in the United Kingdom) and by a plastic spatula (Armovical) were compared for their ability to detect dysplastic cervical epithelium and endocervical cells. At the same time, the value of taking duplicate smears was assessed. Paired cervical smears were obt...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1982-07-01 00:00:00
abstract::Periodic assessments offer an excellent opportunity for obstetricians and gynecologists to provide preventive screening, evaluation, and counseling. The American College of Obstetricians and Gynecologists' Committee on Gynecologic Practice recommends routine assessments in primary and preventive care for women based o...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,评审
doi:10.1097/AOG.0b013e318219226e
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To estimate whether and to what extent interbirth interval is associated with cesarean delivery. METHODS:This is a retrospective cohort study of 2,528 multiparous women who presented to labor and delivery at a single tertiary care obstetric hospital during an 18-month period. Women were grouped by their inte...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e31821c4368
更新日期:2011-07-01 00:00:00
abstract::An in-depth analysis of numbers of obstetric and gynecologic operations from 1979 to 1984 was performed using data from the National Center for Health Statistics. During the study period, there was a decrease in total numbers of obstetric and gynecologic procedures of 1%. During the same five-year period the numbers o...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198606000-00001
更新日期:1986-06-01 00:00:00
abstract::The postpartum dose of Rh immune globulin varies according to an individual laboratory estimation of fetal red blood cells in each mother's peripheral blood. In the United States, a four-step procedure determines the postpartum dose (number of vials of 300 micrograms; 1,500 international units) of Rh immune globulin (...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,评审
doi:10.1097/aog.0b013e3182742eba
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To compare adverse childhood experiences (ACEs) in women with chronic pelvic pain with a control group, and describe occurrence of specific ACEs in women with chronic pelvic pain. METHODS:This case-control study examined the relationship between history of ACEs, traumatic events occurring during childhood as...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000003533
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To investigate risk factors and prevalence of anal incontinence among women with pelvic floor dysfunctions. METHODS:We evaluated 881 women with symptoms of urinary incontinence and/or genital prolapse. Each completed a bowel questionnaire and underwent a detailed medical, surgical, obstetric, and gynecologic...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(02)02215-9
更新日期:2002-10-01 00:00:00
abstract::In patients with a large prolactin-secreting pituitary adenoma, a marked reduction in tumor size may be achieved with bromocriptine therapy. However, before consideration of pregnancy, surgical removal of the lesion usually is advised. A 36-year-old woman with a large extrasellar pituitary macroadenoma was treated wit...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198409001-00001
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To measure the serum levels of interleukin (IL)-8, prostaglandin (PG) F2alpha, and beta-endorphin in parturients with acupuncture treatment and in controls to clarify the effect of acupuncture and duration of labor on the serum levels of substances active in cervical ripening and dilatation. METHODS:A matche...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章
doi:10.1016/s0029-7844(98)00200-2
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To identify the effect of human immunodeficiency virus (HIV) infection on the clinical course of pelvic inflammatory disease (PID). METHODS:Women hospitalized with PID at an urban hospital serving a population at high risk for HIV were studied cross-sectionally. Data abstracted from medical records of 349 wo...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(96)00387-0
更新日期:1997-01-01 00:00:00
abstract::The reported frequency of alcohol abuse during pregnancy was studied in a large urban public hospital in Dallas, Texas. During 1977-1980, 5602 pregnant women were surveyed and 0.7% (95% confidence interval 0.6-0.8%) reported abusing alcohol during pregnancy. In 1987, 1.4% (95% confidence interval 1.3-1.5%) of 1032 pre...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00