Abstract：
OBJECTIVE:To evaluate the efficacy of device-guided slow-paced respiration for reducing the frequency and severity of menopausal hot flushes. METHODS:Perimenopausal or postmenopausal women reporting four or more hot flushes per day were recruited into a parallel-group, randomized trial of slow-paced respiration using a portable guided-breathing device. Women were randomly assigned to use a standard device to practice slowing their resting breathing rate to less than 10 breaths per minute for at least 15 minutes everyday or use an identical-appearing control device programmed to play relaxing nonrhythmic music while monitoring spontaneous breathing. The primary outcome, change in hot flush frequency over 12 weeks, was assessed using data from validated 7-day diaries abstracted by blinded analysts. RESULTS:Among the 123 participants, mean age was 53.4 (±3.4) years. Women reported an average of 8.5 (±3.5) hot flushes per day at baseline. After 12 weeks, women randomized to paced respiration (n=61) reported an average reduction of 1.8 (95% confidence interval [CI] 0.9-2.6) hot flushes per day (-21%) compared with 3.0 (95% CI 2.1-3.8) hot flushes per day (-35%) in the music-listening group (n=62) (P=.048). Paced respiration was associated with a 19% decrease in frequency of moderate-to-severe hot flushes compared with a 44% decrease with music listening (P=.02). CONCLUSION:In this randomized trial, women assigned to device-guided slow-paced respiration reported modest improvements in the frequency and severity of their hot flushes, but the paced respiration intervention was significantly less effective than a music-listening intervention in decreasing the frequency and severity of these symptoms. LEVEL OF EVIDENCE:I.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Huang AJ,Phillips S,Schembri M,Vittinghoff E,Grady Ddoi
10.1097/AOG.0000000000000821subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1130-1138issue
5eissn
0029-7844issn
1873-233Xpii
00006250-201505000-00020journal_volume
125pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:To investigate the value of the combined use of vaginal ultrasonography and endometrial sampling in the office for the diagnosis of endometrial disease in postmenopausal women. METHODS:One hundred forty consecutive postmenopausal women presenting with uterine bleeding or endometrial cells on cervical cytolog...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/0029-7844(94)00421-9
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS:A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conizat...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)01174-1
更新日期：2001-03-01 00:00:00
abstract：:For certain medical conditions, available data and expert opinion support optimal timing of delivery in the late-preterm or early-term period for improved neonatal and infant outcomes. However, for nonmedically indicated early-term deliveries such an improvement has not been demonstrated. Morbidity and mortality rates...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000428649.57622.a7
更新日期：2013-04-01 00:00:00
abstract：:In an ongoing clinical trial, 100 patients with an unruptured ectopic pregnancy of 3.5 cm or less in greatest dimension were treated with an outpatient protocol of methotrexate and citrovorum factor chemotherapy. Methotrexate and citrovorum were given on alternating days until the hCG titer had decreased by 15% on 2 c...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Peer review is the major method used by the scientific community to evaluate manuscripts and decide what is suitable for publication. However, this process in its current design is not bulletproof and is prone to reviewer and editorial bias. Its lack of objectivity and transparency raise concerns that manuscripts migh...
journal_title：Obstetrics and gynecology
pub_type： 社论
doi：10.1097/AOG.0000000000003260
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To evaluate differences between fasting and nonfasting bile acid levels in asymptomatic and symptomatic pregnant women. METHODS:This is a report of two prospective cohort studies describing bile acid levels in the fasting and nonfasting state in pregnancy. The first cohort included asymptomatic women with si...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000004160
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Endocardial fibroelastosis is a congenital heart disease known to cause congestive heart failure in early infancy. We report a case using new modalities for early prenatal diagnosis of endocardial fibroelastosis causing fetal heart failure. CASE:A multipara with two children, who died of endocardial fibroel...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(01)01505-8
更新日期：2001-11-01 00:00:00
abstract：:Recent studies using newly devised serologic techniques have dramatically advanced our understanding of gonadal organogenesis and aberrant sexual differentiation. Thus XY gonadal dysgenesis, XX male syndrome, and XX true hermaphroditism, for example, may be seen as typifying specific errors of regulation, synthesis, o...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1979-12-01 00:00:00
abstract：:This study compared peritoneal fluid volume, macrophage count, and macrophage concentration by diagnosis and cycle week of 426 patients undergoing laparoscopy. Patient diagnosis and cycle week had no significant interaction. Peritoneal fluid volume was dependent upon cycle week and diagnostic group, but macrophage cou...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:To determine whether maternal midtrimester serum N-terminal peptide of proatrial natriuretic peptide, free beta subunit of human chorionic gonadotropin (hCGbeta), or alpha-fetoprotein (AFP) levels can predict preeclampsia. METHODS:A population-based cohort included 1037 nulliparous women, of whom 637 (61%) p...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(98)00112-4
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:CD4+ T-lymphocytopenia immunodeficiency without human immunodeficiency virus (HIV) infection has been reported recently. The association between immunodeficiency and anogenital neoplasia secondary to human papillomavirus infections is well documented. CASE:A woman with recurrent vulvar intraepithelial neopl...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:We studied 30 control women and 131 pill users to evaluate effects of birth control pills and clinical factors on hemostasis. When control patients were matched with an equal number of pill users, none of the direct markers of activated hemostasis (fibrinopeptide A, platelet factor 4, and beta thromboglobulin) were in...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：OBJECTIVE:To compare tubal anastomosis by robotic system compared with outpatient minilaparotomy. METHODS:In this retrospective case-control study, women were identified by current procedural terminology code for tubal anastomosis. We included all cases of tubal anastomosis for reversal of a prior tubal ligation by ei...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000264591.43544.0f
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Epidermal growth factor is a ubiquitous mitogen that also possesses insulin-like properties. Fetal mal-growth is associated with altered epidermal growth factor levels. Maternal diabetes is frequently complicated by macrosomia, but the effect of maternal diabetes on fetal epidermal growth factor levels is not...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000110545.64874.49
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to examine the human teratogenic risk of the protease inhibitor, nelfinavir mesylate, used to treat human immunodeficiency virus. METHODS:This study used a subset of data from the Antiretroviral Pregnancy Registry, which was designed to monitor prenatal exposures to antiretrov...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000127440.68730.23
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of intrauterine local anesthesia in reducing pain associated with outpatient gynecologic procedures. DATA SOURCES:We searched online databases PubMed or MEDLINE, Embase, Google Scholar, and Clinicaltrials.gov and hand-searched reference lists from reviews evaluating pain-control m...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1097/AOG.0b013e3182639ab5
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:To systematically review and integrate data on the neurodevelopmental outcome of children after administration of a single course of antenatal corticosteroids for threatened preterm labor. DATA SOURCES:MEDLINE, Scopus, CENTRAL, and www.clinicaltrials.gov (inception to August 2014) using combinations of the t...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,meta分析,评审
doi：10.1097/AOG.0000000000000748
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Amyloidosis of the endometrium is a rare occurrence according to current literature. Previously reported cases have presented with menorrhagia or postmenopausal bleeding. CASE:A postmenopausal woman with multiple medical problems presented with fatigue and weight loss. During the evaluation for her 18-kg we...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000124985.48138.7e
更新日期：2004-11-01 00:00:00
abstract：:The cardiovascular effects of ritodrine tocolytic therapy were assessed by noninvasive simultaneous recordings of indirect carotid pulse, electrocardiogram (ECG), phonocardiogram, and M-mode echocardiogram in 12 patients in preterm labor. The study was performed before and during infusion, and afterward when the patie...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：OBJECTIVE:To examine the occurrence of multiple risk behaviors during pregnancy among women who delivered a live birth and to examine the risk of delivering small for gestational age (SGA) infants for women with multiple risks. METHODS:We used data from the Pregnancy Risk Assessment Monitoring System to conduct the re...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(01)01324-2
更新日期：2001-05-01 00:00:00
abstract：:Twenty-three patients undergoing second-trimester amniocentesis were ultrasonically monitored for 30 minutes before and 30 minutes after the amniocentesis. Fetal movements were recorded as movements of limbs, trunk, or combined limb-trunk movements. Fetal heart rates were determined at ten-minute intervals before and ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Blood samples were obtained from 145 preovulatory and postovulatory hirsute women and the plasma was analyzed for total testosterone (T), T index, and free T concentration as well as the fraction of free T percentage and that bound by testosterone-estradiol binding globulin. Fifty-six patients were subjected to a 2-we...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:A 64-year-old woman with a 45,X karyotype and Turner's syndrome and recent onset of right lower quadrant pain was found to have a mucinous cystadenoma with focal areas of borderline malignancy and a typical Brenner tumor in the right adnexa. Ovarian tumors in patients with a 45,X karyotype and Turner's syndrome are ex...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:Two hundred sixty-four consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and August 1988 were followed prospectively and evaluated for disease recurrence for 8-112 months (mean 51.5). Thirty-three patients (12.5%) developed recurrence or died...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVE:To estimate the association of maternal plasma concentrations of tryptophan and six kynurenine pathway metabolites with the risk of preeclampsia. METHODS:The study was based on a subsample of 2,936 pregnant women who delivered singleton neonates in the Norwegian Mother and Child Cohort Study in 2002-2003. Ma...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e318255004e
更新日期：2012-06-01 00:00:00
abstract：:Obstructed labor due to a large sacrococcygeal tumor is reported. A technique of transabdominal intrauterine reduction in the size of the tumor to allow delivery of the infant in satisfactory condition is described. The method and the successful outcome have not previously been reported. It is recommended as a combine...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:A review of 540 patients evaluated by the Gynecologic Colposcopy Clinic for abnormal cervical cytology revealed that 372 (68.9%) had cervical intraepithelial neoplasia (CIN), microinvasive carcinoma, or frank invasive carcinoma. The repeat cytologic smear taken before biopsy was falsely negative in 26.4%. An endocervi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/00006250-198309000-00016
更新日期：1983-09-01 00:00:00
abstract：OBJECTIVE:To determine the influence of maternal smoking on fetal erythropoietin concentrations in health term pregnancies and test the correlation between cotinine, a biomarker of maternal smoking, and erythropoietin levels in fetuses. METHODS:We invited women with healthy term pregnancies to participate in the study...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(99)00622-5
更新日期：2000-04-01 00:00:00
abstract：:Conjoined twins occur with a frequency of 1/50,000--1/100,000 deliveries. The cephalothoracopagus variety is particularly rare. This paper presents a case report of cephalothoracopagus (Janiceps) twinning, with a detailed pathologic analysis, as well as an historical review and discussion of diagnostic modalities. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:Reported are 172 patients considered for external cephalic version at gestational age greater than 37 weeks. Their outcome was compared with 40 similar patients in whom external version was not attempted. One hundred fifty-eight patients had attempted version, and success was achieved in 122 (77%). Intrapartum vertex ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
