Comparison of Hemoglobin-based oxygen carriers to stored human red blood cells.

abstract：:The leukotrienes are a group of biologically active products of arachidonic acid metabolism that have been demonstrated to possess the capability to alter vascular reactivity as well as vascular permeability when applied topically to tissues or infused into the vascular bed of various organs. These biologic effects of...

journal_title：Critical care clinics

authors： Sprague RS,Stephenson AH,Dahms TE,Lonigro AJ

更新日期：1989-04-01 00:00:00

abstract：:This article reviews principles in the rational use of antibiotics in sepsis and septic shock and presents evidence-based recommendations for optimal antibiotic therapy. Every patient with sepsis and septic shock must be evaluated at presentation before the initiation of antibiotic therapy. However, in most situations...

journal_title：Critical care clinics

authors： Kumar A

更新日期：2009-10-01 00:00:00

abstract：:This article has reviewed the current knowledge regarding the occurrence and possible role of oxygen radical generation and lipid peroxidation in acute CNS injury. Although much work remains, three criteria required to establish the pathophysiologic importance of oxygen radical reactions in post-traumatic events have ...

journal_title：Critical care clinics

authors： Hall ED

更新日期：1989-10-01 00:00:00

abstract：:Blunt thoracic trauma can result in significant morbidity in injured patients. Both chest wall and the intrathoracic visceral injuries can lead to life-threatening complications if not anticipated and treated. Pain control, aggressive pulmonary toilet, and mechanical ventilation when necessary are the mainstays of sup...

journal_title：Critical care clinics

authors： Wanek S,Mayberry JC

更新日期：2004-01-01 00:00:00

abstract：:The recent development of valid and reliable assessment tools to monitor agitation, sedation, analgesia, and delirium in the ICU represents an essential first step in the provision of patient comfort and the development of preferred treatment strategies. To make the ICU a more humane healing environment, these assessm...

journal_title：Critical care clinics

authors： Fraser GL,Riker RR

更新日期：2001-10-01 00:00:00

abstract：:Measuring cardiac output without knowledge of the oxygen extraction by the tissues is of limited value. Instead of calculating oxygen consumption and oxygen delivery, a diagram relating cardiac index to the oxygen extraction ratio is proposed to interpret hemodynamic data at the bedside. This diagram is particularly h...

journal_title：Critical care clinics

authors： Vincent JL

更新日期：1996-10-01 00:00:00

abstract：:Caring for the new quadriplegic is an immense undertaking involving multiple health care professionals who must function as a team. The physician in charge must understand rehabilitation principles and be able to communicate with all members of the team caring for the patient. Rehabilitation principles, if considered ...

journal_title：Critical care clinics

authors： Keppler JP

更新日期：1987-07-01 00:00:00

abstract：:Fluid creep is the term applied to a burn resuscitation, which requires more fluid than predicted by standard formulas. Fluid creep is common today and is linked to several serious edema-related complications. Increased fluid requirements may accompany the appropriate resuscitation of massive injuries but dangerous fl...

journal_title：Critical care clinics

authors： Saffle JR

更新日期：2016-10-01 00:00:00

abstract：:The future of cardiopulmonary resuscitation lies in new technologies for monitoring and generating vital organ perfusion during cardiac arrest and the post-resuscitation phase and in pharmacologic agents that will enhance ROSC and reverse ischemia-reperfusion injury. ROSC is the first step toward survival, so interven...

journal_title：Critical care clinics

authors： Manning JE,Katz LM

更新日期：2000-10-01 00:00:00

abstract：:Anemia is common in critically ill patients, but treatment with red blood cell transfusions can have unwanted effects. Limiting the occurrence and severity of anemia by using erythropoietic agents (iron and/or recombinant erythropoietin), therefore, remains an attractive option during the intensive care unit stay but ...

journal_title：Critical care clinics

authors： Piagnerelli M,Vincent JL

更新日期：2012-07-01 00:00:00

abstract：:It is as important to monitor the passage of time in the resuscitation effort as it is to follow the physiologic parameters. The goals in resuscitation are based on restoring cellular metabolism to a level consistent with optimum survival. The level of invasiveness of monitoring is dictated by the extent to which the ...

journal_title：Critical care clinics

authors： Booth FV

更新日期：1992-04-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in the United States,and thus its clinical and economic implications are enormous. In an increasingly cost-conscious economic environment, it is important to understand not only the effectiveness of treatments and technologies but also their cost-effectiveness. The ...

journal_title：Critical care clinics

authors： Chen J,Rizzo JA

更新日期：2012-01-01 00:00:00

abstract：:There are numerous mechanisms of hypoxemia and hypercapnia during the perioperative period. Mechanisms of hypoxemia include oxygen delivery problems, decreased FAC-CC relationship, hypoventilation, decreased cardiac output, increased oxygen consumption, decreased hypoxic pulmonary vasoconstriction, and increased nonal...

journal_title：Critical care clinics

authors： Foltz BD,Benumof JL

更新日期：1987-04-01 00:00:00

abstract：:Electronic medical records can be used to mine clinical data (big data), providing automated analysis during patient care. This article describes the source and potential impact of big data analysis on risk stratification and early detection of deterioration. It compares use of big data analysis with existing methods ...

journal_title：Critical care clinics

authors： Wong Lama KM,DeVita MA

更新日期：2018-04-01 00:00:00

abstract：:Multiplane (TEE) transducer imaging is the most highly evolved TEE technology at present. New clinical applications of this technology will be realized as echocardiographers gain experience with it. Current limitations of TEE are likely to be surmounted as its use increases, and continuous improvements and miniaturiza...

journal_title：Critical care clinics

authors： Khandheria BK,Tajik AJ,Seward JB

更新日期：1996-04-01 00:00:00

abstract：:Intoxications frequently perturb acid-base and electrolyte status, intravascular volume, and renal function. In selected cases, extracorporeal techniques effectively restore homeostasis and augment intoxicant removal. The use of 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, is a new and effective treatment ...

journal_title：Critical care clinics

authors： Borkan SC

更新日期：2002-04-01 00:00:00

abstract：:Although our understanding of molecular events in septic shock is growing exponentially, bedside management has changed only incrementally over the last 20 years. In pediatric and adult patients alike, treatment continues to be largely supportive. Morbidity and mortality, though gradually improving, continue to be hig...

journal_title：Critical care clinics

authors： Carcillo JA,Cunnion RE

更新日期：1997-07-01 00:00:00

abstract：:In summary, advances in critical care and mechanical ventilation have resulted in an increased salvage of critically ill patients, a number of whom require long-term ventilation as a means of life support. In addition, the total number of patients receiving long-term ventilation has increased dramatically over the pas...

journal_title：Critical care clinics

authors： Criner GJ,Tzouanakis A,Kreimer DT

更新日期：1994-10-01 00:00:00

abstract：:Infection and/or sepsis biomarkers should help to make the diagnosis and thus initiate therapy earlier, help to differentiate between infectious and sterile inflammation, allow the use of more-specific antimicrobials, shorten the time of antimicrobial use, and ideally identify distinct phenotypes that may benefit from...

journal_title：Critical care clinics

authors： Reinhart K,Meisner M

更新日期：2011-04-01 00:00:00

abstract：:Brain injury represents the major cause of long-term disability and mortality among patients resuscitated from cardiac arrest. Brain-directed therapies include maintenance of normal oxygenation, hemodynamic support to optimize cerebral perfusion, glycemic control, and targeted temperature management. Pertinent guideli...

journal_title：Critical care clinics

authors： Koenig MA

更新日期：2014-10-01 00:00:00

abstract：:Contrast-associated acute kidney injury (CAAKI) is a common iatrogenic condition. The principal risk factors for CAAKI are underlying renal impairment; diabetes in the setting of kidney disease; and intravascular volume depletion, effective or absolute. CAAKI is associated with serious adverse short-term and long-term...

journal_title：Critical care clinics

authors： Weisbord SD,Palevsky PM

更新日期：2015-10-01 00:00:00

abstract：:Intrahospital transport of critically ill patients must be considered as part of the critical care continuum. The level of care provided must be commensurate with the severity of illness. These transfers are intensive in terms of utilization of personnel and resources. Advance preparation and optimal coordination of t...

journal_title：Critical care clinics

authors： Venkataraman ST,Orr RA

更新日期：1992-07-01 00:00:00

abstract：:Critical illness predisposes individuals to highly variable metabolic and immune responses, leading to muscle mass loss, impaired healing, immobility, and susceptibility to infections and cognitive impairment. Recommendations for nutrition in critically ill patients are supported by observational studies, small random...

journal_title：Critical care clinics

authors： Patel JJ,Codner P

更新日期：2016-04-01 00:00:00

abstract：:This article describes the history of critical care medicine's cooperation with ethics, relates some lessons learned from this cooperation, identifies implications for other chronic and acute settings, and gives some suggestions for governmental and social input into the solution of the difficult ethical questions fac...

journal_title：Critical care clinics

authors： Kanoti GA,Orlowski JP,Vinicky J

更新日期：1986-01-01 00:00:00

abstract：:The metabolic response to injury can induce a state of hypermetabolism that results in the rapid loss of the body nitrogen, so that a critical reduction in lean body mass that affects morbidity and mortality can occur in a short period of time. The process also induces a redistribution of the body nitrogen away from t...

journal_title：Critical care clinics

authors： Negro F,Cerra FB

更新日期：1988-07-01 00:00:00

abstract：:In July 2001, the United States Joint Commission on Accreditation of Health care Organizations adopted a new leadership standard that requires department heads in health care organizations to perform at least one Failure Mode and Effects Analysis (FMEA) every year. This proactive approach to error prevention has prove...

journal_title：Critical care clinics

authors： Duwe B,Fuchs BD,Hansen-Flaschen J

更新日期：2005-01-01 00:00:00

abstract：:This article provides an overview of some of the current issues involved in sedation and anxiolysis in the intensive care unit. The problems involved in trying to monitor sedation levels are discussed, as are some of the newer options available for physiologic monitoring of the central nervous system. The problem of a...

journal_title：Critical care clinics

authors： Lowson SM,Sawh S

更新日期：1999-01-01 00:00:00

abstract：:Hemorrhage is the leading cause of preventable death in trauma. Damage control resuscitation relies on permissive hypotension, minimizing crystalloid use, and early implementation of massive transfusion protocols with established blood component ratios. These protocols improve the survival of the severely injured pati...

journal_title：Critical care clinics

authors： Cantle PM,Cotton BA

更新日期：2017-01-01 00:00:00

abstract：:The most important adaptive responses from a physiological stance involved the cardiovascular system, consisting in particular of elevation of the cardiac output and its redistribution to favor the coronary and cerebral circulations, at the expense of the splanchnic vascular beds. The evidence regarding these physiolo...

journal_title：Critical care clinics

authors： Hébert PC,Van der Linden P,Biro G,Hu LQ

更新日期：2004-04-01 00:00:00

abstract：:Transplant patients face challenging medical journeys, with many detours to the intensive care unit. Before and after transplantation, they have significant psychological and cognitive comorbidities, which decrease their quality of life and potentially compromise their medical outcomes. Critical care staff are essenti...

journal_title：Critical care clinics

authors： Sher Y,Zimbrean P

更新日期：2017-07-01 00:00:00