Retinopathy of prematurity: current concepts in molecular pathogenesis.

Abstract:

:Retinopathy of prematurity is marked by the proliferative vascularization of the retina in preterm babies. An understanding of the molecular pathogenesis of ROP provides the basis for identifying novel therapeutic targets for treatment. Using the mouse model of oxygen-induced retinopathy, the roles of the hypoxia induced factors vascular endothelial growth factor and erythropoietin as well as the maternally derived factors insulin-like growth factor-1 and omega-3 polyunsaturated fatty acids have begun to be elucidated. Understanding the phase specific effects of these factors will serve to guide the development of non destructive treatments for ROP and for other ischemic retinopathies including diabetic retinopathy and neovascular age-related macular degeneration.

journal_name

Semin Ophthalmol

authors

Heidary G,Vanderveen D,Smith LE

doi

10.1080/08820530902800314

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

77-81

issue

2

eissn

0882-0538

issn

1744-5205

pii

910514921

journal_volume

24

pub_type

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