Delayed type hypersensitivity in the pathogenesis of recurrent herpes stromal keratitis.

Abstract:

:Recurrent herpes stromal keratitis (HSK) is one of the leading causes of blindness in the developed world. Cyokines characteristic of Th1 cells (in particular IFN-γ and IL-2) have been shown to dominate in HSK in addition to mechanisms by nonspecific, antigen-independent effector cells such as neutrophils, basophils, and monocytes. More recently, the migration and maturation of dendritic cells (DC) within the corneal stroma of patients with HSK have been recognized as contributors to recurrent disease, suggesting a role for delayed type hypersensitivity (DTH) in the immunopathogenesis of HSK. The role of DC and DTH in recurrent HSK has not been studied extensively and experimental models of recurrent HSK focusing on DTH as the pathogenesis and viral particles as the triggering antigen may contribute to better understanding of the disease.

journal_name

Semin Ophthalmol

authors

Hawthorne KM,Dana R,Chodosh J

doi

10.3109/08820538.2011.588659

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

246-50

issue

4-5

eissn

0882-0538

issn

1744-5205

journal_volume

26

pub_type

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