Abstract:
:Currently, there is no proven drug treatment for dry age-related macular degeneration (AMD). Several different treatment strategies are being investigated, including complement inhibition, neuroprotection, and visual cycle inhibitors, and novel clinical trial endpoints are being explored. Studies have identified genetic predispositions for dry AMD associated with complement dysfunction. Consequently, complement-based therapeutic treatment modalities are promising.
journal_name
Semin Ophthalmoljournal_title
Seminars in ophthalmologyauthors
Yehoshua Z,Rosenfeld PJ,Albini TAdoi
10.3109/08820538.2011.577132subject
Has Abstractpub_date
2011-05-01 00:00:00pages
167-80issue
3eissn
0882-0538issn
1744-5205journal_volume
26pub_type
杂志文章,评审abstract::Retinopathy of prematurity is marked by the proliferative vascularization of the retina in preterm babies. An understanding of the molecular pathogenesis of ROP provides the basis for identifying novel therapeutic targets for treatment. Using the mouse model of oxygen-induced retinopathy, the roles of the hypoxia indu...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530902800314
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:Amblyopia is a leading cause of low vision and warrants timely management during childhood. We performed a literature review of the management of amblyopia and potential risk factors for amblyopia. METHODS:Literature review of the management of amblyopia and risk factors for amblyopia. RESULTS:Common amblyopi...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2016.1228408
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To report a case of fungal corneal ulcer and bacterial orbital cellulitis as complications of bacterial endophthalmitis following cataract surgery. METHODS:A 51-year-old man underwent anterior chamber irrigation and aspiration in the left eye one day after cataract surgery because of bacterial endophthalmitis....
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2012.760613
更新日期:2013-03-01 00:00:00
abstract:AIM:Investigating the retinal nerve fiber layer (RNFL), macular and ganglion cell complex thickness in eyes of migraine patients using optical coherence tomography. METHODS:The study was designed as an observational cross-sectional study. 50 patients with migraine (30 patients with aura and 20 patients without aura) a...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.833270
更新日期:2015-03-01 00:00:00
abstract::A wide variety of infectious agents are known to cause optic neuropathy. This article will consider the bacteria, spirochetes, fungi, and viruses that most commonly affect the optic nerve. Clinical presentation is variable, but some pathogens often produce a characteristic funduscopic pattern. Diagnosis is usually mad...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1076/soph.17.1.11.10293
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of a modified double extra sharp chopper for removal of hard cataracts. DESIGN:Prospective non-comparative interventional clinical study. PARTICIPANTS:Forty eyes from 25 patients with hard mature cataract grades 3-4. METHODS:The pre-modified Koch chopper was sharpened unde...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2010.482846
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To investigate thickness of the retinal nerve fiber layer (RNFL) and choroid thickness in patients with pseudoexfoliation syndrome (PEX) and pseudoexfoliation glaucoma (PXG) compared to healthy volunteers. METHODS:This cross-sectional, prospective study included 43 patients with PXG, 45 patients with PEX syndr...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1090611
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Endothelial keratoplasty (EKP) has become increasingly popular in the treatment of corneal disease. However, the global shortage of human donor corneas limits clinical corneal transplantation. Genetically engineered (GE) pigs may provide an alternative source of corneas for EKP. The aim of this study was to eva...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.787104
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:We would like to describe a case report of posterior ischemic optic neuropathy (PION) misdiagnosed as arteritic PION with presumed GCA which leads to missing the correct diagnosis with fatal outcome. METHODS:The clinical course of a single patient will be described including presentation, testing,diagnosis a...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820530903392902
更新日期:2009-11-01 00:00:00
abstract::Cosmetic eyelid surgery has benefited from the use of the carbon dioxide laser. The short pulsed laser cuts through tissue with limited surrounding thermal damage, resulting in incisions that heal with minimal scarring comparable to traditional cold steel methods. The laser provides excellent hemostasis, which shorten...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539809066084
更新日期:1998-09-01 00:00:00
abstract::Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, describes a condition of elevated intracranial pressure (ICP) that typically presents in obese women of childbearing age with symptoms and signs of posture-dependent headaches, pulsatile tinnitus, visual changes, and papilledema. Optical coherence tom...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2010.518462
更新日期:2010-09-01 00:00:00
abstract::Purposes: To evaluate the accuracy of Ophtha Top and consistency between Ophtha Top and IOLMaster 500 in intraocular lens refractive power calculation among cataract patients with normal and long axial lengths. Methods: This study included cataract patients scheduled for phacoemulsification and IOL implantation surger...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2020.1871033
更新日期:2021-01-17 00:00:00
abstract::A 61-year-old female presented with a moderate decrease in vision in the left eye. The patient denied any other ocular or systemic symptoms related to giant cell arteritis. Visual acuity was 20/50 in the left eye with a 2+ relative afferent pupillary defect and markedly abnormal color vision. Dilated fundus examinatio...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820530490882715
更新日期:2004-09-01 00:00:00
abstract::Although the cause of IIH remains obscure, it has become clear that loss of visual function is common and patients may progress to blindness. Diagnosis should adhere to the modified Dandy criteria. Recent case-control studies cast doubt on the validity of many frequently cited conditions associated with IIH. Valid ass...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539509060979
更新日期:1995-09-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a common cause of legal blindness in the developed countries in people older than 50 years of age. AMD complicated by choroidal neovascular membranes (CNV) accounts for 12% of AMD, but for 88% of legal blindness cases. Because of the progressive aging of the population, it is ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539909056057
更新日期:1999-03-01 00:00:00
abstract::Leber congenital amaurosis (LCA) is a congenital retinal dystrophy that was first described almost 150 years ago. LCA still remains an important cause of blindness with about 20% of children in schools for the blind being affected by it. LCA has genetic heterogeneity and the study of this disease is elucidating the ge...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530701745215
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To evaluate the results of scleral-fixated posterior chamber intraocular lenses (SFIOL) in pediatric and adult patients. METHODS:We carried out a retrospective analysis of 129 eyes of 120 patients (adult group, n = 96; pediatric group, n = 24) who underwent SFIOL implantation. Outcome measures were indications...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.835834
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Investigate risk factors for unplanned return to the operating room after resident-performed cataract surgery. DESIGN:Retrospective case-control study. SETTING:Institutional. METHODS:Study population: All patients with reoperation within 90 days of resident-performed phacoemulsification were matched to fou...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2016.1208760
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To describe the in-vivo confocal microscopy corneal findings in a patient with bilateral corneal deposits caused by an underlying monoclonal gammopathy. METHODS:A 68-year-old man came to our center for an ophthalmologic examination. Besides visual acuity, the examination included slit-lamp biomicroscopy, intra...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2012.730102
更新日期:2013-01-01 00:00:00
abstract::Purpose: To compare the success rates and safety of transscleral cyclophotocoagulation (TSCPC) for the treatment of refractory glaucoma using the slow coagulation technique and the conventional technique. Methods: A retrospective, interventional case series of 44 patients (44 eyes) who underwent TSCPC using the slow c...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1638946
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To evaluate vision-related quality of life in patients with chronic central serous chorioretinopathy (CSCR). DESIGN:Prospective, cross-sectional study. METHODS:The interviewer-administered National Eye Institute visual function questionnaire (NEI-VFQ-25) was used in 30 adult consecutive patients with chronic ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.839818
更新日期:2015-07-01 00:00:00
abstract::Vogt-Koyanagi-Harada syndrome is a bilateral, chronic, diffuse granulomatous panuveitis associated with poliosis, vitiligo, and central nervous system and auditory signs. Increasing reports have been published to describe the clinical features of Vogt-Koyanagi-Harada syndrome. These manifestations are variable. This a...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2011.588654
更新日期:2011-07-01 00:00:00
abstract::Purpose: The purpose of this study was to investigate the changes of optical coherence tomography angiography (OCTA) parameters in diabetic retinopathy (DR) using an updated software with 3D projection artifact removal. Methods: In this cross-sectional observational study, 192 eyes of 111 patients with diabetes mellit...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2020.1845386
更新日期:2020-08-17 00:00:00
abstract::Transpupillary thermotherapy (TTT) has been suggested as a putative treatment for choroidal neovascularization (CNV) in age-related macular degeneration (AMD). This prospective study comprised 66 consecutive patients referred for exudative AMD with predominantly occult subfoveal CNV. Based on fluorescein angiography, ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1076/soph.16.2.90.4210
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:To compare the efficacy of combined manual small incision cataract and glaucoma surgery with anterior chamber maintainer (ACM) alone versus that with intraoperative viscoelastics. METHODS:Hospital electronic medical records of patients who underwent small incision cataract and trabeculectomy and intraocular le...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2017.1339092
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To describe utilization trends of an ophthalmology-specific emergency department (ED). METHODS:Prospective cohort study of new patients presenting in the ophthalmology ED for at least a 30-day period in the spring of each year for five consecutive years (2010-14) at a university referral center. A data form,...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2016.1188129
更新日期:2018-01-01 00:00:00
abstract::Several new aqueous inflow inhibitors have been introduced over the past few years. These new agents include two alpha agonists, two topical carbonic anhydrase inhibitors, and a novel combination agent. All of these agent compare favorably with timolol in terms of aqueous suppression, though each has its own relative ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539909061469
更新日期:1999-09-01 00:00:00
abstract::Glaucoma drainage devices are more frequently being used for glaucoma filtering surgeries, even those at low risk for failure with trabeculectomy. There are 4 major devices available: the Molteno, Baerveldt, Krupin, and Ahmed. The Molteno and Baerveldt are non-valved implants, while the Krupin and Ahmed are valved. Th...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2010.518840
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The primary objective of this article is to present a summary of different types of image processing methods employed for the detection of glaucoma, a serious eye disease. INTRODUCTION:Glaucoma affects the optic nerve in which retinal ganglion cells become dead, and this leads to loss of vision. The principa...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2016.1229801
更新日期:2018-01-01 00:00:00
abstract::Evaluation of patients after trabeculectomy can be aided by the use of anterior segment imaging. Two commonly used forms of imaging are ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT). Both modalities can be used to assess bleb morphology and how it affects treatment outcome, measure anterior cha...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2012.707275
更新日期:2012-09-01 00:00:00