Abstract:
PURPOSE:To report a novel plasminogen gene mutation and detection of anti-plasminogen antibodies in a patient with ligneous conjunctivitis successfully treated with 60% fresh frozen plasma (FFP). METHODS:Retrospective data collected on a 45-year-old Caucasian female presenting with unilateral chronic membranous lesions. RESULTS:Laboratory investigation demonstrated decreased plasminogen antigen level, plasminogen activity, and rate of plasminogen activation by u-PA or t-PA, and elevated plasminogen activator inhibitor-1. Anti-plasminogen IgG and IgA antibodies were detected. DNA analysis revealed a novel Asp432Asn heterozygous missense mutation in the plasminogen gene (exon 11). The patient was treated with topical 60% FFP, achieved complete remission after four months, and remained membrane-free for over five years of follow-up. CONCLUSIONS:A novel plasminogen gene mutation, deficiency of plasminogen antigen and activity, and anti-plasminogen IgG and IgA antibodies were identified in a patient with adult-onset ligneous conjunctivitis. Sixty percent FFP maintained this patient disease-free for over five years.
journal_name
Semin Ophthalmoljournal_title
Seminars in ophthalmologyauthors
Tu Y,Gonzalez-Gronow M,Kolomeyer AM,Cohen A,Pruzon J,Milman T,Chu DSdoi
10.3109/08820538.2015.1005319subject
Has Abstractpub_date
2016-01-01 00:00:00pages
526-31issue
6eissn
0882-0538issn
1744-5205journal_volume
31pub_type
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