Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature.

Abstract:

PURPOSE:To report a novel plasminogen gene mutation and detection of anti-plasminogen antibodies in a patient with ligneous conjunctivitis successfully treated with 60% fresh frozen plasma (FFP). METHODS:Retrospective data collected on a 45-year-old Caucasian female presenting with unilateral chronic membranous lesions. RESULTS:Laboratory investigation demonstrated decreased plasminogen antigen level, plasminogen activity, and rate of plasminogen activation by u-PA or t-PA, and elevated plasminogen activator inhibitor-1. Anti-plasminogen IgG and IgA antibodies were detected. DNA analysis revealed a novel Asp432Asn heterozygous missense mutation in the plasminogen gene (exon 11). The patient was treated with topical 60% FFP, achieved complete remission after four months, and remained membrane-free for over five years of follow-up. CONCLUSIONS:A novel plasminogen gene mutation, deficiency of plasminogen antigen and activity, and anti-plasminogen IgG and IgA antibodies were identified in a patient with adult-onset ligneous conjunctivitis. Sixty percent FFP maintained this patient disease-free for over five years.

journal_name

Semin Ophthalmol

authors

Tu Y,Gonzalez-Gronow M,Kolomeyer AM,Cohen A,Pruzon J,Milman T,Chu DS

doi

10.3109/08820538.2015.1005319

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

526-31

issue

6

eissn

0882-0538

issn

1744-5205

journal_volume

31

pub_type

杂志文章,评审
  • Evaluation of a New IOL Power Calculator in Cataract Patients with Normal and Long Axial Lengths.

    abstract::Purposes: To evaluate the accuracy of Ophtha Top and consistency between Ophtha Top and IOLMaster 500 in intraocular lens refractive power calculation among cataract patients with normal and long axial lengths. Methods: This study included cataract patients scheduled for phacoemulsification and IOL implantation surger...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2020.1871033

    authors: Yu S,Lu CZ,Zhao Y,Song H

    更新日期:2021-01-17 00:00:00

  • Utilization of Ophthalmology-Specific Emergency Department Services.

    abstract:OBJECTIVE:To describe utilization trends of an ophthalmology-specific emergency department (ED). METHODS:Prospective cohort study of new patients presenting in the ophthalmology ED for at least a 30-day period in the spring of each year for five consecutive years (2010-14) at a university referral center. A data form,...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2016.1188129

    authors: Sridhar J,Isom RF,Schiffman JC,Ajuria L,Huang LC,Gologorsky D,Banta JT

    更新日期:2018-01-01 00:00:00

  • Who (what) pays toll for the development of herpetic stromal keratitis (HSK).

    abstract::In the herpetic stromal keratitis (HSK), HSV DNA fragments and HSV-IgG immune complexes (HSV-IC) are present in most of the corneas long after infective virus has disappeared. These viral components are highly immunogenic and potentiate production of proinflammatory cytokines and chemokines via Toll-like receptors (TL...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1080/08820530802111408

    authors: Hayashi K,Hooper LC,Hooks JJ

    更新日期:2008-07-01 00:00:00

  • Ocular Manifestations, Conventional Fundus Fluorescein Angiographic Findings, and Relationship Between Angiographic Findings and Visual Acuity in Behçet's Disease.

    abstract:PURPOSE:Evaluating the ocular manifestation and fundus fluorescein angiography (FA) findings of patients with Behçet's disease as well as the relationship between visual acuity and angiographic findings. METHODS:Retrospective chart review of patients with Behçet's disease seen at the Farabi Eye Hospital. RESULTS:Fort...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2016.1178310

    authors: Bazvand F,Zarei M,Ebrahimiadib N,Karkhaneh R,Davoudi S,Soleimanzadeh M,Sharifian E,Roohipoor R,Modjtahedi BS

    更新日期:2017-01-01 00:00:00

  • Percentage Choroidal Thickness: Another View on Analysis of Choroidal Thickness Using Spectral-domain Optical Coherence Tomography.

    abstract::Purpose: To present an analysis of the percentage choroidal thickness (PCT) and evaluate PCT profile in eyes with different axial length (AL). Methods: Axial length (AL) measurements and spectral domain optical coherence tomography examinations, including radial 9-mm scan and 4 circle scans with diameter of 3.0, 5.0, ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2019.1636096

    authors: Maltsev DS,Kulikov AN,Burnasheva MA,Chhablani J

    更新日期:2019-01-01 00:00:00

  • Ranibizumab (Lucentis) versus Bevacizumab (Avastin) for the Treatment of Age-Related Macular Degeneration: An Economic Disparity of Eye Health.

    abstract::Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and the advent of anti-vascular endothelial growth factor agents (VEGF) has revolutionized treatment for neovascular AMD. Two of the most popular anti-VEGF agents, ranibizumab (Lucentis; Genentech/Roche) and bevacizumab (Avastin; ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820538.2016.1154174

    authors: Moreno TA,Kim SJ

    更新日期:2016-01-01 00:00:00

  • Crash and Burn: Ocular Injuries due to Fireworks.

    abstract:PURPOSE:To identify the patterns of ocular injury and to determine ocular morbidity resulting from the use of firecrackers. METHODS:A prospective observational study of all patients presenting with ocular trauma consequent to fireworks usage in a tertiary eye care center in South India over a one-month period around t...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2014.962157

    authors: Patel R,Mukherjee B

    更新日期:2016-01-01 00:00:00

  • Prevalence and Risk Factors for Polypoidal Choroidal Vasculopathy in a General Japanese Population: The Hisayama Study.

    abstract:PURPOSE:To estimate the prevalence and risk factors for polypoidal choroidal vasculopathy (PCV) in a general Japanese population. METHODS:This population-based, cross-sectional study was conducted in 2007 with subjects from the Hisayama Study. Of the 3,648 residents in Hisayama, Japan, 2,663 who were ≥ 50 years old we...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/08820538.2018.1506483

    authors: Fujiwara K,Yasuda M,Hata J,Oshima Y,Hashimoto S,Yoshitomi T,Kiyohara Y,Ishibashi T,Ninomiya T,Sonoda KH

    更新日期:2018-01-01 00:00:00

  • Anatomical Characterization of an Optic Disc Notch Using SD-OCT in Glaucoma.

    abstract:PURPOSE:To characterize anatomical dimensions of a disc notch using novel methods using spectral domain optical coherence tomography (SD-OCT). PARTICIPANTS:All age- and severity-matched glaucoma patients with disc notch (defined as complete loss of neural rim with no residual rim between disc and cup) seen from 2014 t...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2018.1540709

    authors: Rao A,Kaza H,Padhy D,Das G,Sarangi S

    更新日期:2018-01-01 00:00:00

  • Clinical update on normal tension glaucoma.

    abstract::Normal tension glaucoma (NTG) is a common form of open-angle glaucoma that can lead to significant visual morbidity. There has been considerable debate as to whether NTG fits within the spectrum of primary open-angle glaucoma (POAG). The relative roles of intraocular pressure and pressure-independent factors in this d...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820538.2013.771202

    authors: Mudumbai RC

    更新日期:2013-05-01 00:00:00

  • Unruptured Giant Intracranial Aneurysm of the Internal Carotid Artery: Late Ocular Symptoms.

    abstract::An unruptured giant intracranial aneurysm of the internal carotid artery may tend to present with late ocular symptoms. This is the case of a 58-year-old female patient with a giant unruptured aneurysm of the right internal carotid artery. The patient presented with exclusively progressive reduction of visual acuity a...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2014.912548

    authors: Zorić Geber M,Krolo I,Zrinscak O,Tedeschi Reiner E,Zivkovic DJ

    更新日期:2016-01-01 00:00:00

  • The Histopathological Findings of Patients Who Underwent Blepharoplasty Due to Dermatochalasis.

    abstract:PURPOSE:To assess changes in lymphatic vessels, collagen, and elastic fiber structure in excised tissues with dermatochalasis (DC). METHODS:In this prospective histopathological study, 70 upper eyelid skins of 35 patients operated on for dermatochalasis were compared with 10 eyelid skins of 10 patients operated on for...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2017.1282970

    authors: Karnaz A,Katircioglu YA,Ozdemir ES,Celebli P,Hucumenoglu S,Ornek F

    更新日期:2018-01-01 00:00:00

  • Autosomal dominant hereditary optic neuropathy (ADOA): a review of the genetics and clinical manifestations of ADOA and ADOA+.

    abstract::Autosomal dominant hereditary optic atrophy (ADOA), also known as Kjer's syndrome, is a common hereditary cause of progressive bilateral vision loss. Recent advancements in the understanding of the genetics of this condition have revealed that a single gene may account for a large portion of the clinical manifestation...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820538.2013.825296

    authors: Skidd PM,Lessell S,Cestari DM

    更新日期:2013-09-01 00:00:00

  • Sterile corneal melting and necrotizing scleritis after cataract surgery in patients with rheumatoid arthritis and collagen vascular disease.

    abstract::The onset of post-operative corneal melting and necrotizing scleritis in patients with rheumatoid arthritis and collagen vascular disease who undergo cataract surgery can have devastating ocular and systemic consequences. Even though ocular surface factors such as sicca and surgical trauma are among the important vari...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1076/soph.17.3.124.14786

    authors: Perez VL,Azar DT,Foster CS

    更新日期:2002-09-01 00:00:00

  • Retinopathy of prematurity: current concepts in molecular pathogenesis.

    abstract::Retinopathy of prematurity is marked by the proliferative vascularization of the retina in preterm babies. An understanding of the molecular pathogenesis of ROP provides the basis for identifying novel therapeutic targets for treatment. Using the mouse model of oxygen-induced retinopathy, the roles of the hypoxia indu...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1080/08820530902800314

    authors: Heidary G,Vanderveen D,Smith LE

    更新日期:2009-03-01 00:00:00

  • Quantitative Comparison of the Effect of 10% Phenylephrine Instillation and Manual Elevation in Patients with Involutional Blepharoptosis.

    abstract:OBJECTIVE:To compare the effect of 10% phenylephrine (PE) instillation and manual elevation (ME) on the upper eyelid position of the tested eye and the contralateral eye in patients with involutional blepharoptosis (IB). METHODS:IB patients were submitted to two tests followed by observation of the effect on the contr...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2015.1045152

    authors: Pereira IC,Matayoshi S

    更新日期:2017-01-01 00:00:00

  • Vision-related quality of life in patients with chronic central serous chorioretinopathy.

    abstract:PURPOSE:To evaluate vision-related quality of life in patients with chronic central serous chorioretinopathy (CSCR). DESIGN:Prospective, cross-sectional study. METHODS:The interviewer-administered National Eye Institute visual function questionnaire (NEI-VFQ-25) was used in 30 adult consecutive patients with chronic ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2013.839818

    authors: Türkcü FM,Şahin A,Bez Y,Yüksel H,Cinar Y,Kürşat Cingü A,Çaça İ

    更新日期:2015-07-01 00:00:00

  • Infrequent Complications of Inferior Oblique Recession Surgery.

    abstract:PURPOSE:To report the infrequent complications, including antielevation and adherence syndrome, after a unilateral and bilateral inferior oblique (IO) recession procedure and to discuss the possible causes. METHODS:A retrospective chart review was conducted for patients on whom unilateral or bilateral IO weakening sur...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2015.1132332

    authors: Niyaz L,Yücel OE,Gul A

    更新日期:2017-01-01 00:00:00

  • Scheimpflug imaging in dermatochalasis patients before and after upper eyelid blepharoplasty.

    abstract:PURPOSE:The aim of this study was to evaluate corneal parameters obtained by Scheimpflug imaging of dermatochalasis patients both preoperatively and after blepharoplasty. MATERIALS AND METHODS:Sixty eyes of 30 patients (22 female, 8 male), which were operated upon for the upper eyelid, were included in the study. Pati...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2013.839803

    authors: Dogan E,Akbas Kocaoglu F,Yalniz-Akkaya Z,Elbeyli A,Burcu A,Ornek F

    更新日期:2015-05-01 00:00:00

  • Success Rates of Endoscopic-Assisted Probing Compared to Conventional Probing in Children 48 Months or Older.

    abstract:BACKGROUND:To evaluate the success rates of endoscopic-assisted probing compared to conventional probing in children 48 months or older. METHODS:This retrospective study included children 48 months and older with CNLDO who underwent endoscopic-assisted probing or conventional probing between January 2011 to August 201...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2017.1284872

    authors: Galindo-Ferreiro A,Khandekar R,Akaishi PM,Cruz A,Gálvez-Ruiz A,Dolmetsch A,Schellini S

    更新日期:2018-01-01 00:00:00

  • Macula and retinal nerve fiber layer in migraine patients: analysis by spectral domain optic coherence tomography.

    abstract:AIM:Investigating the retinal nerve fiber layer (RNFL), macular and ganglion cell complex thickness in eyes of migraine patients using optical coherence tomography. METHODS:The study was designed as an observational cross-sectional study. 50 patients with migraine (30 patients with aura and 20 patients without aura) a...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2013.833270

    authors: Yülek F,Dirik EB,Eren Y,Simavlı H,Uğurlu N,Çağıl N,Şimşek Ş

    更新日期:2015-03-01 00:00:00

  • A Retrospective Study of Transcleral Cyclophotocoagulation Using the Slow Coagulation Technique for the Treatment of Refractory Glaucoma.

    abstract::Purpose: To compare the success rates and safety of transscleral cyclophotocoagulation (TSCPC) for the treatment of refractory glaucoma using the slow coagulation technique and the conventional technique. Methods: A retrospective, interventional case series of 44 patients (44 eyes) who underwent TSCPC using the slow c...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2019.1638946

    authors: Fong YYY,Wong BKT,Li FCH,Young AL

    更新日期:2019-01-01 00:00:00

  • Risk Factors for Poor Quality of Life among Patients with Age-Related Macular Degeneration.

    abstract:PURPOSE:The purpose of this study was to evaluate the quality of life in patients with age-related macular degeneration (AMD) and compare it with that of healthy controls. Additionally, our study aims to investigate the possible risk factors for poor quality of life in AMD patients. METHODS:Participants in the study w...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2016.1181192

    authors: Chatziralli I,Mitropoulos P,Parikakis E,Niakas D,Labiris G

    更新日期:2017-01-01 00:00:00

  • New aqueous inflow inhibitors.

    abstract::Several new aqueous inflow inhibitors have been introduced over the past few years. These new agents include two alpha agonists, two topical carbonic anhydrase inhibitors, and a novel combination agent. All of these agent compare favorably with timolol in terms of aqueous suppression, though each has its own relative ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820539909061469

    authors: Doyle JW,Smith MF

    更新日期:1999-09-01 00:00:00

  • Cotton wool spots associated with interferon beta-1 alpha therapy.

    abstract:PURPOSE:To describe a case of cotton wool spots associated with interferon beta-1a treatment. METHODS:Observational case report. RESULTS:A 40-year-old man with a history of multiple sclerosis was on interferon beta-1a. He presented with cotton wool spots on fundus exam, which resolved and then recurred all while on t...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820530601182725

    authors: Longmuir R,Lee AG,Rouleau J

    更新日期:2007-01-01 00:00:00

  • Lymphomatoid papulosis of the eyelid.

    abstract::Lymphomatoid papulosis (LyP) is a chronic papulonecrotic or papulonodular skin disease, with histological features suggestive of malignant lymphoma. It was originally described by Macauley (1968) as a "self-healing paradoxical eruption, histologically malignant but clinically benign." Unless accompanied by systemic ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2012.680643

    authors: Cloke A,Lim LT,Kumarasamy M,Roberts F,Kemp EG

    更新日期:2013-01-01 00:00:00

  • Dilated iris vasculature in the setting of the neonatal hypoxic encephelopathy.

    abstract::The differential diagnosis of dilated iris vasculature in a neonate includes retinopathy of prematurity with anterior segment plus disease, persistent fetal vasculature, intrauterine cocaine exposure, maternal diabetes, and other pathologies associated with iris neovascularization and ischemia seen in adult population...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.3109/08820538.2013.844266

    authors: Gorovoy IR,Vaccari JC

    更新日期:2015-07-01 00:00:00

  • Scleral Thinning Documented by Ultrasound Biomicroscopy after Plaque Therapy for Anterior Ciliary Melanoma.

    abstract:PURPOSE:To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma. METHODS:Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation ...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章

    doi:10.1080/08820538.2017.1346131

    authors: Kuzmanović Elabjer B,Bušić M,Miletić D,Bjeloš M,Vukojević N,Bosnar D

    更新日期:2018-01-01 00:00:00

  • Genetics of ectopia lentis.

    abstract::Hereditary ectopia lentis or lens subluxation can occur with and without systemic associations. Significant overlap can be found in the genetic mutations and pathogenesis of subluxated lenses in their isolated forms as well as with associated syndromes. Gene mutations have been identified for lens subluxation associat...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820538.2013.825276

    authors: Sadiq MA,Vanderveen D

    更新日期:2013-09-01 00:00:00

  • Use of optical coherence tomography to evaluate papilledema and pseudopapilledema.

    abstract::Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, describes a condition of elevated intracranial pressure (ICP) that typically presents in obese women of childbearing age with symptoms and signs of posture-dependent headaches, pulsatile tinnitus, visual changes, and papilledema. Optical coherence tom...

    journal_title:Seminars in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.3109/08820538.2010.518462

    authors: Heidary G,Rizzo JF 3rd

    更新日期:2010-09-01 00:00:00