Abstract:
PURPOSE:Vascular anomalies comprise malformations, hemangiomas, and rare tumors. The commonality among these lesions is their origin in vascular endothelia. Most occur sporadically, but occasional inheritance is observed and thus allows genetic research and insight into etiology. This review highlights those vascular anomalies in which genetic inheritance has been demonstrated. METHODS:A comprehensive literature search was performed on PubMed. Fifty-five full-length articles were reviewed. RESULTS:Five categories of vascular anomalies with patterned inheritance were identified: arteriovenous malformation (AVM), capillary malformation (CM), lymphatic malformation (LM), venous malformation (VM), and infantile hemangioma (IH). Capillary and arteriovenous malformation subtypes are associated with a RASA-1 gene mutation and show autosomal dominant inheritance. VEGFR3 mutations have been associated with generalized forms of LM and lymphedema. Mutations in TIE2/TEK genes cause inherited forms of venous malformations also with autosomal dominant inheritance. Familial clustering and atopic disease are associated with infantile hemangioma, and gene expression varies with the developmental stage of these lesions. CONCLUSION:Most vascular anomalies occur sporadically, but several genes and genetic disorders have been associated with them. Specific forms of capillary malformation appear to be most convincingly associated with genomic errors. Further research promises new insights into the development of this diverse group of disorders.
journal_name
Semin Ophthalmoljournal_title
Seminars in ophthalmologyauthors
Yadav P,De Castro DK,Waner M,Meyer L,Fay Adoi
10.3109/08820538.2013.825279subject
Has Abstractpub_date
2013-09-01 00:00:00pages
257-66issue
5-6eissn
0882-0538issn
1744-5205journal_volume
28pub_type
杂志文章,评审abstract:PURPOSE:Evaluating the ocular manifestation and fundus fluorescein angiography (FA) findings of patients with Behçet's disease as well as the relationship between visual acuity and angiographic findings. METHODS:Retrospective chart review of patients with Behçet's disease seen at the Farabi Eye Hospital. RESULTS:Fort...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2016.1178310
更新日期:2017-01-01 00:00:00
abstract::Corneal topography plays an important role in laser in situ keratomileusis (LASIK). Preoperative screening permits the detection of keratoconus and other corneal shape anomalies that may be a contraindication for refractive surgery. Monitoring the progress of the surgical outcome with topography is helpful to detect p...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539809059820
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abstract::Recurrent herpes stromal keratitis (HSK) is one of the leading causes of blindness in the developed world. Cyokines characteristic of Th1 cells (in particular IFN-γ and IL-2) have been shown to dominate in HSK in addition to mechanisms by nonspecific, antigen-independent effector cells such as neutrophils, basophils, ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2011.588659
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abstract::Intraocular gas tamponades are an important part of vitreoretinal surgery and have become a standard of care. The use of intraocular gas began in 1911. Modem use of intraocular gases as a surgical adjunct is continuously broadening. Today, sulfur hexafluoride and perfluoropropane are increasingly being used as intraoc...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
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abstract:PURPOSE:To evaluate the safety, efficacy, and outcomes of early bicanalicular silicone intubation in the treatment of acute purulent dacryocystitis. METHODS:This prospective interventional case series focused on acute purulent dacryocystitis from February 2010 to March 2014. Of the 21 cases, 16 cases were treated at t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1139737
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Glaucoma is one of the leading causes of blindness worldwide. Treatment is still largely targeted at lowering intraocular pressure. Intraocular pressures can be lowered through a variety of topical medications, lasers and incisional surgeries. There are currently several classes of topical medications availa...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2020.1818796
更新日期:2020-08-17 00:00:00
abstract:CONTEXT:Results on refractive keratectomy of the treatment of young patients with purely refractive accommodative esotropia. AIMS:Evaluating the results of refractive keratectomy (PRK) on the treatment of young patients with purely refractive accommodative esotropia. METHODS AND MATERIAL:This prospective study compri...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.810286
更新日期:2015-01-01 00:00:00
abstract::The current management of acute post-operative endophthalmitis relies on microbial confirmation, intravitreal antibiotics, and vitrectomy. The endophthalmitis vitrectomy study (EVS) demonstrated that systemic antibiotics are not necessary in post-cataract/secondary intraocular lens (IOL) acute bacterial endophthalmiti...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1076/soph.18.3.109.29804
更新日期:2003-09-01 00:00:00
abstract::Purposes: To evaluate the accuracy of Ophtha Top and consistency between Ophtha Top and IOLMaster 500 in intraocular lens refractive power calculation among cataract patients with normal and long axial lengths. Methods: This study included cataract patients scheduled for phacoemulsification and IOL implantation surger...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2020.1871033
更新日期:2021-01-17 00:00:00
abstract::Syphilis is a sexually transmitted, chronic, systemic infection caused by the spirochete Treponema pallidum. If left untreated, the disease progresses through four stages, with the potential to cause significant morbidity to any major organ of the body. Frequent syphilitic ocular manifestations, which can occur at any...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2018.1443146
更新日期:2018-01-01 00:00:00
abstract::Current ultra-wide field (UWF) retinal imaging systems utilize scanning laser ophthalmoscope technology combined with an ellipsoidal mirror to capture up to 200 degrees of the retina in a single image. When compared with mydriatic ETDRS-protocol, 7 standard field photographs and clinical examination, nonmydriatic UWF ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2012.708812
更新日期:2012-09-01 00:00:00
abstract::Although the cause of IIH remains obscure, it has become clear that loss of visual function is common and patients may progress to blindness. Diagnosis should adhere to the modified Dandy criteria. Recent case-control studies cast doubt on the validity of many frequently cited conditions associated with IIH. Valid ass...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539509060979
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:We hypothesized that the ongoing neurotrophic effects of electroconvulsive therapy (ECT) might be detected in the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT). METHODS:This study was conducted using a prospective design. The RNFL thickness alterations of 18 psychiatric patients ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2018.1538419
更新日期:2018-01-01 00:00:00
abstract::Paroxysmal hemicrania is a trigeminal autonomic cephalalgia first described in 1976, characterized by episodic attacks of excruciating unilateral periorbital and temporal stabbing, pulsatile, craw-like, or boring headaches lasting 2 - 30 minutes, accompanied by autonomic features, and alleviated by indomethacin. Parox...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820531003635505
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To compare the effect of 10% phenylephrine (PE) instillation and manual elevation (ME) on the upper eyelid position of the tested eye and the contralateral eye in patients with involutional blepharoptosis (IB). METHODS:IB patients were submitted to two tests followed by observation of the effect on the contr...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1045152
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in retinal and choroidal thickness maps following uncomplicated phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS:A prospective study was done on 66 eyes. EDI-OCT was performed preoperative, 1 week, 1 month, and 3 months postoperative meas...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2017.1417453
更新日期:2018-01-01 00:00:00
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1638946
更新日期:2019-01-01 00:00:00
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.814693
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journal_title:Seminars in ophthalmology
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doi:10.3109/08820538.2013.844266
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.833260
更新日期:2015-03-01 00:00:00
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2013.825296
更新日期:2013-09-01 00:00:00
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539909061469
更新日期:1999-09-01 00:00:00
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journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1132332
更新日期:2017-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and the advent of anti-vascular endothelial growth factor agents (VEGF) has revolutionized treatment for neovascular AMD. Two of the most popular anti-VEGF agents, ranibizumab (Lucentis; Genentech/Roche) and bevacizumab (Avastin; ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2016.1154174
更新日期:2016-01-01 00:00:00
abstract::Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn's disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and other clinical variables.Methods: This prospective cross-sectional case-control study at a t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1684525
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe the clinical features of patients with Duane retraction syndrome (DRS) and evaluate the outcomes of surgical approaches based on the characteristics of each patient. METHODS:The records of 38 Caucasian subjects with DRS were retrospectively reviewed. The patients were classified as type I, II, or I...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2018.1554746
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To assess changes in lymphatic vessels, collagen, and elastic fiber structure in excised tissues with dermatochalasis (DC). METHODS:In this prospective histopathological study, 70 upper eyelid skins of 35 patients operated on for dermatochalasis were compared with 10 eyelid skins of 10 patients operated on for...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2017.1282970
更新日期:2018-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a progressive degenerative disease which leads to blindness, affecting the quality of life of millions of Americans. More than 1.75 million individuals in the United States are affected by the advanced form of AMD. The etiological pathway of AMD is not yet fully understood, bu...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2011.577129
更新日期:2011-05-01 00:00:00
abstract::Laser photocoagulation of the entire area of the neovascular lesion is the only proven treatment for subfoveal choroidal neovascularization secondary to age-related macular degeneration with a poor natural history. However, there are some limiting factors such as patient eligibility, a significant decline in visual ac...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539809066080
更新日期:1998-03-01 00:00:00