Abstract:
:Age-related macular degeneration (AMD) is a progressive degenerative disease which leads to blindness, affecting the quality of life of millions of Americans. More than 1.75 million individuals in the United States are affected by the advanced form of AMD. The etiological pathway of AMD is not yet fully understood, but there is a clear genetic influence on disease risk. To date, the 1q32 (CFH) and 10q26 (PLEKHA1/ARMS2/HTRA1) loci are the most strongly associated with disease; however, the variation in these genomic regions alone is unable to predict disease development with high accuracy. Therefore, current genetic studies are aimed at identifying new genes associated with AMD and their modifiers, with the goal of discovering diagnostic or prognostic biomarkers. Moreover, these studies provide the foundation for further investigation into the pathophysiology of AMD by utilizing a systems-biology-based approach to elucidate underlying mechanistic pathways.
journal_name
Semin Ophthalmoljournal_title
Seminars in ophthalmologyauthors
Deangelis MM,Silveira AC,Carr EA,Kim IKdoi
10.3109/08820538.2011.577129subject
Has Abstractpub_date
2011-05-01 00:00:00pages
77-93issue
3eissn
0882-0538issn
1744-5205journal_volume
26pub_type
杂志文章,评审abstract:PURPOSE:Amblyopia is a leading cause of low vision and warrants timely management during childhood. We performed a literature review of the management of amblyopia and potential risk factors for amblyopia. METHODS:Literature review of the management of amblyopia and risk factors for amblyopia. RESULTS:Common amblyopi...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2016.1228408
更新日期:2017-01-01 00:00:00
abstract::Ophthalmology, like any other clinical science, is constantly evolving. As our knowledge in this field expands, we enumerate and describe classical triads of symptoms or signs with relevance to ophthalmology in this article. Characteristic clinical triads for certain systemic conditions with ocular implications are al...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2015.1045150
更新日期:2017-01-01 00:00:00
abstract::We present a case of retinopathy found incidentally in an asymptomatic patient receiving treatment with interferon beta 1a for multiple sclerosis. She was found to have peripheral dot and blot hemorrhages with no cotton wool spots. It is possible that interferon beta 1a retinopathy is more common than previously repor...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.814693
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To report the ocular findings, systemic hematologic parameters, and treatment outcomes of patients with recurrent central retinal vein occlusions (CRVO). METHODS:A retrospective analysis of eyes that developed recurrent CRVO was performed. Key exclusion criteria were follow-up of less than six months after the...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1080/08820538.2016.1188130
更新日期:2018-01-01 00:00:00
abstract::Purpose: To investigate the clinical characteristics of perifoveal exudative vascular anomalous complex (PEVAC) in Korean patients. Methods: This retrospective study included 8 eyes (8 patients) diagnosed with PEVAC. Demographic characteristics of the patients, fundus photography, optical coherence tomography (OCT), f...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1626450
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this paper is to perform a systematic review of the published literature on complications of intra-arterial chemothrapy (IAC) for the treatment of retinoblastoma. MATERIALS AND METHODS:A literature search was performed using the Pubmed database using the terms. Complications were divided in...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2014.959188
更新日期:2014-09-01 00:00:00
abstract::Paroxysmal hemicrania is a trigeminal autonomic cephalalgia first described in 1976, characterized by episodic attacks of excruciating unilateral periorbital and temporal stabbing, pulsatile, craw-like, or boring headaches lasting 2 - 30 minutes, accompanied by autonomic features, and alleviated by indomethacin. Parox...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820531003635505
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in retinal and choroidal thickness maps following uncomplicated phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS:A prospective study was done on 66 eyes. EDI-OCT was performed preoperative, 1 week, 1 month, and 3 months postoperative meas...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2017.1417453
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To describe the use of photoscreening for preschool vision screening in several diverse locations throughout the world. METHODS:The MTI photo screener was used to screen pre-verbal children; photographs were interpreted using standard criteria. RESULTS:The Tennessee vision screening program remains successful...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820530802506078
更新日期:2008-09-01 00:00:00
abstract::Subconjunctival prolapse of orbital fat is an uncommon clinical entity in which intraconal orbital fat herniates into the subconjunctival space. Its diagnosis is mainly clinical in character and usually based on palpation, patient clinical history, and lesion features along with a slit lamp examination. Its pathophysi...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1576743
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Vernal keratoconjunctivitis (VKC) is a bilateral multi-factorial disease. The pathogenesis of this disease is not obviously determined, but the role of various inflammatory cytokines has been specified. This study has provided a comparison between the level of interleukin-17 (IL17) in the serum and tears o...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1170162
更新日期:2017-01-01 00:00:00
abstract::We describe a report of a child with a horner's syndrome and sixth nerve paresis secondary to a petrous internal carotid artery (ICA) aneurysm. Management of this condition involved coiling of the aneurysm and the use of botulinum toxin to manage his strabismus and associated symptoms. ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2010.541321
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma. METHODS:Case report. RESULTS:A 33-year-old women who had been under paroxetine treatment for the past four months presented at the emergency room due to a sud...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.771193
更新日期:2013-07-01 00:00:00
abstract::We briefly review the history and principles of photodynamic therapy (PDT), especially as it is applied to choroidal neovascularization (CNV) in age-related macular degeneration (AMD). After a brief general history of PDT, we discuss the relationship between the physicochemical structure and photodynamic activity of t...
journal_title:Seminars in ophthalmology
pub_type: 历史文章,杂志文章,评审
doi:10.1076/soph.16.4.181.10299
更新日期:2001-12-01 00:00:00
abstract::Macular hole formation is a rare complication of cataract extraction. Although the exact etiology is unclear, macular holes can be classified into pre-existing holes that may not have been visible prior to cataract surgery, early stage macular holes that progressed to a more advanced stage, symptomatic holes following...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1076/soph.17.3.196.14775
更新日期:2002-09-01 00:00:00
abstract::Evaluation of patients after trabeculectomy can be aided by the use of anterior segment imaging. Two commonly used forms of imaging are ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT). Both modalities can be used to assess bleb morphology and how it affects treatment outcome, measure anterior cha...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2012.707275
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To assess amniotic membrane retention after amniotic membrane transplant in bullous keratopathy patients and whether there were any corneal structural changes that may hinder further penetrating keratoplasty Methods: A retrospective study including 22 patients who have undergone amniotic membrane transplant fro...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1620790
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To evaluate the safety, efficacy, and outcomes of early bicanalicular silicone intubation in the treatment of acute purulent dacryocystitis. METHODS:This prospective interventional case series focused on acute purulent dacryocystitis from February 2010 to March 2014. Of the 21 cases, 16 cases were treated at t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1139737
更新日期:2017-01-01 00:00:00
abstract::The current management of acute post-operative endophthalmitis relies on microbial confirmation, intravitreal antibiotics, and vitrectomy. The endophthalmitis vitrectomy study (EVS) demonstrated that systemic antibiotics are not necessary in post-cataract/secondary intraocular lens (IOL) acute bacterial endophthalmiti...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1076/soph.18.3.109.29804
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To evaluate the characteristics of macular edema (ME) before and after radial optic neurotomy (RON) detected by optical coherence tomography (OCT), in patients with central retinal vein occlusion (CRVO). DESIGN:Interventional case series. METHODS:Five eyes of 5 patients affected by CRVO underwent RON. Complet...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820530490519961
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To present a case of unilateral development of severe corneal vascularization in the eye of a keratoconic patient implanted with Intacs microthin prescription inserts and concurrent bilateral use of rigid gas permeable (RGP) contact lenses. METHODS:A 20-year-old male underwent unilateral implantation of Intacs...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2011.588646
更新日期:2012-01-01 00:00:00
abstract::In the herpetic stromal keratitis (HSK), HSV DNA fragments and HSV-IgG immune complexes (HSV-IC) are present in most of the corneas long after infective virus has disappeared. These viral components are highly immunogenic and potentiate production of proinflammatory cytokines and chemokines via Toll-like receptors (TL...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530802111408
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To compare the effect of 10% phenylephrine (PE) instillation and manual elevation (ME) on the upper eyelid position of the tested eye and the contralateral eye in patients with involutional blepharoptosis (IB). METHODS:IB patients were submitted to two tests followed by observation of the effect on the contr...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1045152
更新日期:2017-01-01 00:00:00
abstract::The opportunity to perform two or more ophthalmic operations simultaneously has increased in recent years. In keratoplasty too, the simultaneous operation consisting of cataract extraction and IOL insertion (triple procedure) has become common. Penetrating keratoplasty (PKP) and planned extracapsular cataract extracti...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1076/soph.16.3.126.4197
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:To employ optical coherence tomography (OCT) to examine the relationship of changes in the retinal nerve fiber layer (RNFL) and macular thickness as well as ganglion cell (GC) parameters with the stage of keratoconus (KC), and to compare these changes with a control group. METHODS:A total of 84 eyes of 68 pati...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1169302
更新日期:2017-01-01 00:00:00
abstract::The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherence tomographs (OCT)-of the retina. This instrument permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539809056053
更新日期:1998-12-01 00:00:00
abstract::Purpose: To compare the success rates and safety of transscleral cyclophotocoagulation (TSCPC) for the treatment of refractory glaucoma using the slow coagulation technique and the conventional technique. Methods: A retrospective, interventional case series of 44 patients (44 eyes) who underwent TSCPC using the slow c...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1638946
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To assess changes in lymphatic vessels, collagen, and elastic fiber structure in excised tissues with dermatochalasis (DC). METHODS:In this prospective histopathological study, 70 upper eyelid skins of 35 patients operated on for dermatochalasis were compared with 10 eyelid skins of 10 patients operated on for...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2017.1282970
更新日期:2018-01-01 00:00:00
abstract::Secondary causes of ocular surface disease are-to a large extent-due to disorders of the ocular adnexae. The main pathomechanisms involved include exposure, abrasion and malnutrition, resulting from a multitude of disorders such as ec- or entropion (e.g. in cicatrizing conjunctivitis), lid retraction and severe aqueou...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530590931377
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To describe a case of hypertension and retinitis pigmentosa presenting with a unilateral macular star. METHODS:Case report. RESULTS:A 17-year-old female with chronic kidney disease and hypertension presented with a mild blurring of vision in the left eye. There was a history of night blindness. Both eyes had ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1132331
更新日期:2017-01-01 00:00:00