Abstract:
OBJECTIVES:There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association between diabetes and hearing loss, however, this relationship is still a matter of debate. We investigated the association of diabetes and sensorineural hearing loss in an animal model of type-2 diabetes and obesity (the ob/ob mouse [OM]). METHODS:The auditory brainstem response (ABR) thresholds were obtained in the OM and the wild type mice (C57BL/6J mice) up to 25 weeks after birth. After the animals were sacrificed, their cochleae were retrieved and then subjected to histopathologic observations. RESULTS:The OM exhibited significantly elevated ABR thresholds at 21 weeks of age, yet the C57BL/6J mice exhibited no significant change until 25 weeks of age. On the histological findings, outer hair cell degeneration and loss of spiral ganglion cells were observed in the middle and basal turns of the OM. On the contrary, no degenerative change was observed until 25 weeks of age in the C57BL/6J mice. CONCLUSION:This study suggests that chronic hyperglycemia and obesity may lead to early sensorineural hearing loss.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Lee HS,Kim KR,Chung WH,Cho YS,Hong SHdoi
10.3342/ceo.2008.1.4.211subject
Has Abstractpub_date
2008-12-01 00:00:00pages
211-6issue
4eissn
1976-8710issn
2005-0720journal_volume
1pub_type
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pub_type: 杂志文章,评审
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doi:10.3342/ceo.2013.6.4.214
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doi:10.3342/ceo.2015.8.2.123
更新日期:2015-06-01 00:00:00
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
doi:10.3342/ceo.2011.4.1.27
更新日期:2011-03-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.3.139
更新日期:2012-09-01 00:00:00