Abstract:
:Prognosis in relapsed metastatic head and neck squamous cell cancer (RM-HNSCC) is dismal. Platinum based chemotherapy in combination with Cetuximab is used in first-line setting, while no further validated options are available at progression. Immunotherapy has produced durable clinical benefit in some patients with RM-HNSCC although the premises are several patients are nonresponders. Studies are ongoing to determine predictive factors and the ideal setting/combination of novel immunotherapies. In this paper, we discuss the past and present of immunotherapy in head and neck cancer and provide an up-to-date information regarding the potential ways to improve immunotherapy outcomes in HNSCC.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Denaro N,Merlano MCdoi
10.21053/ceo.2018.00150subject
Has Abstractpub_date
2018-12-01 00:00:00pages
217-223issue
4eissn
1976-8710issn
2005-0720pii
ceo.2018.00150journal_volume
11pub_type
杂志文章abstract:OBJECTIVES:The purpose of this study was to evaluate the advantages and limitations of using a silicon tube to support the fractured orbital floor by a transantral approach. METHODS:A retrospective study was conducted from January 2000 to December. 2011 in 51 patients with pure orbital floor fractures. The patients un...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.3.250
更新日期:2015-09-01 00:00:00
abstract::Juvenile hyaline fibromatosis (JHF) is a rare, progressive autosomal recessive disease that's characterized by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions. We present here the case of a 2-yr-old boy with JHF along with a review of the relevant li...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.2.102
更新日期:2010-06-01 00:00:00
abstract::A schwannoma of the larynx is a rare benign tumor that usually presents as a submucosal mass in the pyriform sinus and the aryepiglottic space, and this type of schwannoma constitutes a diagnostic and therapeutic challenge for otolaryngologists. We present here two cases of supraglottic schwannomas that were misdiagno...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.3.166
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:Patients with bilateral vocal fold paralysis (BVFP) theoretically have difficulty producing voiceless consonants. However, perceptual studies have revealed clear production of voiceless consonants with good articulation scores in nontracheostomized patients. The purpose of this study was to clarify the produ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2016.00626
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses. METHODS:Twenty-five retrospective case-series studies were included in these analyses...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2017.00717
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The nuclear protein high mobility group protein box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of proinflammatory mediators, and it has recently emerged as a key player in different acute and chronic immune disorders. Several lines of evidence demonstrate that HMGB1 is activel...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.2.123
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To prevent hypoparathyroidism after thyroidectomy, preservation of the parathyroid glands and their vascularity are essential. The aim of this study was to determine the association between postoperative parathyroid function and the viability of the parathyroid glands during thyroidectomy. METHODS:We prospe...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2016.00724
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.2.97
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:Some changes are found in the labyrinth anatomy during postnatal development. Although the spatial orientation of semicircular canals was thought to be stable after birth, we investigated the age-related orientational changes of human semicircular canals during development. METHODS:We retrospectively studie...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2014.02012
更新日期:2016-06-01 00:00:00
abstract::Meningioma's account for around 15% of all primary brain tumors with some 10% of meningiomas arising in the posterior fossa. In rare cases, a meningioma can form around the endolymphatic sac. When formed in the posterior fossa, meningioma tumors can produce vague, non-specific vertiginous symptoms. Research has observ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.4.234
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. METHODS:This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01368
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:Evaluation of a new material, high-density porous polyethylene (HDPP), which is covered with fascia lata, for experimental nasal septal perforation closure. METHODS:Twenty New Zealand albino rabbits were included and divided into study and control groups. A lateral incision was made from the lateral aspect ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2011.4.3.137
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:This study was conducted evaluate the efficacy of electromyography (EMG) using transcartilaginous (TC) electrodes through the thyroid cartilage and perichondrium. METHODS:We prospectively collected EMG data from intraoperative neuromonitoring (IONM) of 54 nerves at risk in 38 patients during thyroidectomy. ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.01529
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis. METHODS:Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patient...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.00395
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:This study prospectively evaluated postthyroidectomy syndrome (PTS) through objective and subjective voice changes following thyroidectomy of open vs. endoscopic thyroidectomy. METHODS:A prospective clinical trial (SCHBC IRB 09 26) was performed from Jan 2008 to Aug 2010 to compare the open thyroidectomy (O...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.1.76
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:In an effort to improve hearing aid users' satisfaction, recent studies on trainable hearing aids have attempted to implement one or two environmental factors into training. However, it would be more beneficial to train the device based on the owner's personal preferences in a more expanded environmental aco...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01690
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Somatostatin inhibits lymph production and reduces lymph flow into the lymphatic duct. We hypothesized that octreotide, a long-acting somatostatin analog, would reduce drainage after neck dissection (ND) by reducing the overall lymphatic flow in the neck as well as thoracic duct flow. METHODS:From 2012 to 2...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.00073
更新日期:2016-06-01 00:00:00
abstract:Objectives:Although unilateral hearing loss (UHL) has been proven to be associated with educational and behavioral problems, few studies have investigated psychopathological abnormalities in this population. The aim of this study was to evaluate the psychopathological influence of UHL among Korean 19-year-old males. M...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.00283
更新日期:2020-07-27 00:00:00
abstract:OBJECTIVES:Free flaps are widely used to reconstruct head and neck defects. Despite the improvement in the surgical techniques and the surgeons' experiences, flap failures still occur due to thrombotic occlusion after small vessels anastomosis. To reduce the possibility of flap loss as a result of thrombotic occlusion,...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01781
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.S1.S6
更新日期:2012-04-01 00:00:00
abstract:Objectives:Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the local-regional advanced stage (stage IVa) but their treatment with upfront surgery vs. definite chemoradiation therapy (CRT) is controversial. The purpose of the present study is to compare overall survival (OS) and disease-free s...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.01732
更新日期:2020-09-25 00:00:00
abstract:OBJECTIVES:To evaluate characteristic computed tomography (CT) and magnetic resonance (MR) imaging findings of granulocytic sarcomas of the head and neck. METHODS:The CT (n=11) and MR (n=1) images obtained from 11 patients (7 males and 4 females; mean age, 23.5 yr; age range, 1 to 69 yr) with histologically-proven gra...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2009.2.2.66
更新日期:2009-06-01 00:00:00
abstract::Laser surgery (LS) or radiotherapy (RT) is normally recommended in early glottic cancer. The objective of this study was to perform a comprehensive meta-analysis of acoustic and perceptual outcomes to compare voice quality of LS or RT in early-stage glottic cancer. Data sources were obtained after searching PubMed, Go...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.21053/ceo.2018.00990
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association betwe...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.4.211
更新日期:2008-12-01 00:00:00
abstract::Sleep surgery is part of a continuum of care for obstructive sleep apnea (OSA) that involves medical, pharmacologic, and behavioral therapy. Upper airway surgery for OSA can significantly improve stability by way of modulating the critical negative closing pressure. This is the same mechanism of action as positive air...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.21053/ceo.2020.01053
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate the clinical results of atticoantrotomy in patients with an attic cholesteatoma. METHODS:Ninety-eight ears in 98 patients were operated on using atticoantrotomy between October 2002 and December 2006. A retrospective review of the otology database (operative findings and methods, pos...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2009.2.1.39
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:In onco-hematological diseases, the incidence of paranasal sinuses infection dramatically increase and requires a combination of medical and surgical therapy. Balloon dilatation surgery (DS) is a minimally invasive, tissue preserving procedure. The study evaluates the results of DS for rhinosinusitis in immu...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.4.302
更新日期:2014-12-01 00:00:00
abstract::Low grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is an extremely rare variant of nasopharyngeal cancer, which exhibits distinct clinicopathological characteristics. Surgical resection has been regarded as the principal treatment. For this, transpalatal or transfacial approach has been classically used for ex...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.1.48
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2018.00878
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:Obesity rates have been increasing for all population groups worldwide, leading to the increased development of various diseases. This study was designed is to identify the relationships between obesity and several important otorhinolaryngologic diseases, including chronic otitis media (COM), chronic rhinosi...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.3.194
更新日期:2015-09-01 00:00:00