Immunotherapy in Head and Neck Squamous Cell Cancer.

Abstract:

:Prognosis in relapsed metastatic head and neck squamous cell cancer (RM-HNSCC) is dismal. Platinum based chemotherapy in combination with Cetuximab is used in first-line setting, while no further validated options are available at progression. Immunotherapy has produced durable clinical benefit in some patients with RM-HNSCC although the premises are several patients are nonresponders. Studies are ongoing to determine predictive factors and the ideal setting/combination of novel immunotherapies. In this paper, we discuss the past and present of immunotherapy in head and neck cancer and provide an up-to-date information regarding the potential ways to improve immunotherapy outcomes in HNSCC.

authors

Denaro N,Merlano MC

doi

10.21053/ceo.2018.00150

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

217-223

issue

4

eissn

1976-8710

issn

2005-0720

pii

ceo.2018.00150

journal_volume

11

pub_type

杂志文章
  • Transantral Orbital Floor Fracture Repair Using a Folded Silastic Tube.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the advantages and limitations of using a silicon tube to support the fractured orbital floor by a transantral approach. METHODS:A retrospective study was conducted from January 2000 to December. 2011 in 51 patients with pure orbital floor fractures. The patients un...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.3.250

    authors: Kim JY,Choi G,Kwon JH

    更新日期:2015-09-01 00:00:00

  • Juvenile hyaline fibromatosis.

    abstract::Juvenile hyaline fibromatosis (JHF) is a rare, progressive autosomal recessive disease that's characterized by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions. We present here the case of a 2-yr-old boy with JHF along with a review of the relevant li...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2010.3.2.102

    authors: Park KT,Chang DY,Sung MW

    更新日期:2010-06-01 00:00:00

  • Schwannoma mimicking laryngocele.

    abstract::A schwannoma of the larynx is a rare benign tumor that usually presents as a submucosal mass in the pyriform sinus and the aryepiglottic space, and this type of schwannoma constitutes a diagnostic and therapeutic challenge for otolaryngologists. We present here two cases of supraglottic schwannomas that were misdiagno...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2010.3.3.166

    authors: Park KT,Ahn Y,Kim KH,Kwon TK

    更新日期:2010-09-01 00:00:00

  • The Phonetic Characteristics in Patients of Bilateral Vocal Fold Paralysis Without Tracheotomy.

    abstract:OBJECTIVES:Patients with bilateral vocal fold paralysis (BVFP) theoretically have difficulty producing voiceless consonants. However, perceptual studies have revealed clear production of voiceless consonants with good articulation scores in nontracheostomized patients. The purpose of this study was to clarify the produ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2016.00626

    authors: Hong YT,Park MJ,Shin YJ,Minh PHN,Hong KH

    更新日期:2017-09-01 00:00:00

  • Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis.

    abstract:OBJECTIVES:This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses. METHODS:Twenty-five retrospective case-series studies were included in these analyses...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2017.00717

    authors: Kim BH,Park SJ,Jeong WJ,Ahn SH

    更新日期:2018-03-01 00:00:00

  • Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death.

    abstract:OBJECTIVES:The nuclear protein high mobility group protein box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of proinflammatory mediators, and it has recently emerged as a key player in different acute and chronic immune disorders. Several lines of evidence demonstrate that HMGB1 is activel...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.2.123

    authors: Cavone L,Cuppari C,Manti S,Grasso L,Arrigo T,Calamai L,Salpietro C,Chiarugi A

    更新日期:2015-06-01 00:00:00

  • Postoperative Hypoparathyroidism and the Viability of the Parathyroid Glands During Thyroidectomy.

    abstract:OBJECTIVES:To prevent hypoparathyroidism after thyroidectomy, preservation of the parathyroid glands and their vascularity are essential. The aim of this study was to determine the association between postoperative parathyroid function and the viability of the parathyroid glands during thyroidectomy. METHODS:We prospe...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2016.00724

    authors: Ji YB,Song CM,Sung ES,Jeong JH,Lee CB,Tae K

    更新日期:2017-09-01 00:00:00

  • Detection of MAGE and SSX gene expressions by RT-nested PCR using common primers in head and neck cancer.

    abstract:OBJECTIVES:The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2008.1.2.97

    authors: Song DW,Shin SJ,Kim DE,Jung SG,Park JW,Lee KD

    更新日期:2008-06-01 00:00:00

  • The Age-Related Orientational Changes of Human Semicircular Canals.

    abstract:OBJECTIVES:Some changes are found in the labyrinth anatomy during postnatal development. Although the spatial orientation of semicircular canals was thought to be stable after birth, we investigated the age-related orientational changes of human semicircular canals during development. METHODS:We retrospectively studie...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2014.02012

    authors: Lyu HY,Chen KG,Yin DM,Hong J,Yang L,Zhang TY,Dai PD

    更新日期:2016-06-01 00:00:00

  • A posterior petrous meningioma with recurrent vertigo.

    abstract::Meningioma's account for around 15% of all primary brain tumors with some 10% of meningiomas arising in the posterior fossa. In rare cases, a meningioma can form around the endolymphatic sac. When formed in the posterior fossa, meningioma tumors can produce vague, non-specific vertiginous symptoms. Research has observ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.4.234

    authors: Choi SJ,Lee JB,Bae JH,Yoon JH,Lee HJ,Kim CH,Park K,Choung YH

    更新日期:2012-12-01 00:00:00

  • Disability of Hearing Impairment Is Positively Associated With Urine Albumin/Creatinine Ratio in Korean Adults: The 2011-2012 Korea National Health and Nutrition Examination Survey.

    abstract:OBJECTIVES:The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. METHODS:This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01368

    authors: Kim YS,Lee DH,Chae HS,Lee TK,Sohn TS,Jeong SC,Kim HY,Lee JI,Song JY,Yeo CD,Lee YB,Ahn HS,Hong M,Han K

    更新日期:2016-09-01 00:00:00

  • The reconstruction of nasal septal perforation with high density porous polyethylene covered with fascia lata: an experimental study on rabbit model.

    abstract:OBJECTIVES:Evaluation of a new material, high-density porous polyethylene (HDPP), which is covered with fascia lata, for experimental nasal septal perforation closure. METHODS:Twenty New Zealand albino rabbits were included and divided into study and control groups. A lateral incision was made from the lateral aspect ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2011.4.3.137

    authors: Yildirim G,Onar V,Sayin I,Onol SD,Aydin T

    更新日期:2011-09-01 00:00:00

  • Efficacy of Transcartilaginous Electrodes for Intraoperative Neural Monitoring During Thyroid Surgery.

    abstract:OBJECTIVES:This study was conducted evaluate the efficacy of electromyography (EMG) using transcartilaginous (TC) electrodes through the thyroid cartilage and perichondrium. METHODS:We prospectively collected EMG data from intraoperative neuromonitoring (IONM) of 54 nerves at risk in 38 patients during thyroidectomy. ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2019.01529

    authors: Jung SM,Tae K,Song CM,Lee SH,Jeong JH,Ji YB

    更新日期:2020-11-01 00:00:00

  • Expression of Serum PTTG1 in Laryngeal Carcinoma and Its Correlation to Prognosis.

    abstract:OBJECTIVES:The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis. METHODS:Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patient...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2019.00395

    authors: Ma K,Sun X,Ma L,Zhang S

    更新日期:2020-02-01 00:00:00

  • Does Postthyroidectomy Syndrome Really Exist Following Thyroidectomy? Prospective Comparative Analysis of Open vs. Endoscopic Thyroidectomy.

    abstract:OBJECTIVES:This study prospectively evaluated postthyroidectomy syndrome (PTS) through objective and subjective voice changes following thyroidectomy of open vs. endoscopic thyroidectomy. METHODS:A prospective clinical trial (SCHBC IRB 09 26) was performed from Jan 2008 to Aug 2010 to compare the open thyroidectomy (O...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.1.76

    authors: Park KN,Mok JO,Chung CH,Lee SW

    更新日期:2015-03-01 00:00:00

  • A Trainable Hearing Aid Algorithm Reflecting Individual Preferences for Degree of Noise-Suppression, Input Sound Level, and Listening Situation.

    abstract:OBJECTIVES:In an effort to improve hearing aid users' satisfaction, recent studies on trainable hearing aids have attempted to implement one or two environmental factors into training. However, it would be more beneficial to train the device based on the owner's personal preferences in a more expanded environmental aco...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01690

    authors: Yoon SH,Nam KW,Yook S,Cho BH,Jang DP,Hong SH,Kim IY

    更新日期:2017-03-01 00:00:00

  • Effect of Octreotide Injection on Postoperative Drainage After Neck Dissection: A Preliminary Report of a Prospective, Matched Case-Control Study.

    abstract:OBJECTIVES:Somatostatin inhibits lymph production and reduces lymph flow into the lymphatic duct. We hypothesized that octreotide, a long-acting somatostatin analog, would reduce drainage after neck dissection (ND) by reducing the overall lymphatic flow in the neck as well as thoracic duct flow. METHODS:From 2012 to 2...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.00073

    authors: Ahn D,Jeon JH,Kim H,Sohn JH

    更新日期:2016-06-01 00:00:00

  • Increased Risk of Psychopathological Abnormalities in Subjects With Unilateral Hearing Loss: A Cross-Sectional Study.

    abstract:Objectives:Although unilateral hearing loss (UHL) has been proven to be associated with educational and behavioral problems, few studies have investigated psychopathological abnormalities in this population. The aim of this study was to evaluate the psychopathological influence of UHL among Korean 19-year-old males. M...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2020.00283

    authors: Song JJ,Ku EJ,Kim S,Kim E,Choi YS,Jung HJ

    更新日期:2020-07-27 00:00:00

  • Testing a New Anticoagulation Method for Free Flap Reconstruction of Head and Neck Cancers.

    abstract:OBJECTIVES:Free flaps are widely used to reconstruct head and neck defects. Despite the improvement in the surgical techniques and the surgeons' experiences, flap failures still occur due to thrombotic occlusion after small vessels anastomosis. To reduce the possibility of flap loss as a result of thrombotic occlusion,...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01781

    authors: Karimi E,Ardestani SH,Jafari M,Hagh AB

    更新日期:2016-12-01 00:00:00

  • Auditory Evoked Potentials under Active and Passive Hearing Conditions in Adult Cochlear Implant Users.

    abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.S1.S6

    authors: Obuchi C,Harashima T,Shiroma M

    更新日期:2012-04-01 00:00:00

  • Survival benefits from surgery of stage IVa head and neck squamous cell carcinoma: A multi-institutional analysis of 1033 cases.

    abstract:Objectives:Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the local-regional advanced stage (stage IVa) but their treatment with upfront surgery vs. definite chemoradiation therapy (CRT) is controversial. The purpose of the present study is to compare overall survival (OS) and disease-free s...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2020.01732

    authors: Park JO,Park YM,Jeong WJ,Shin YS,Hong YT,Choi IJ,Kim JW,Woo SH,Kim YS,Chang JW,Kim MS,Jung KY,Ahn SH,Kim CH,Hong KH,Chung PS,Kim YM,Kim SH,Baek SK

    更新日期:2020-09-25 00:00:00

  • Granulocytic Sarcoma in the Head and Neck: CT and MR Imaging Findings.

    abstract:OBJECTIVES:To evaluate characteristic computed tomography (CT) and magnetic resonance (MR) imaging findings of granulocytic sarcomas of the head and neck. METHODS:The CT (n=11) and MR (n=1) images obtained from 11 patients (7 males and 4 females; mean age, 23.5 yr; age range, 1 to 69 yr) with histologically-proven gra...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2009.2.2.66

    authors: Noh BW,Park SW,Chun JE,Kim JH,Kim HJ,Lim MK

    更新日期:2009-06-01 00:00:00

  • Perceptual and Acoustic Outcomes of Early-Stage Glottic Cancer After Laser Surgery or Radiotherapy: A Meta-Analysis.

    abstract::Laser surgery (LS) or radiotherapy (RT) is normally recommended in early glottic cancer. The objective of this study was to perform a comprehensive meta-analysis of acoustic and perceptual outcomes to compare voice quality of LS or RT in early-stage glottic cancer. Data sources were obtained after searching PubMed, Go...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.21053/ceo.2018.00990

    authors: Lee SH,Hong KH,Kim JS,Hong YT

    更新日期:2019-08-01 00:00:00

  • Early sensorineural hearing loss in ob/ob mouse, an animal model of type 2 diabetes.

    abstract:OBJECTIVES:There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association betwe...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2008.1.4.211

    authors: Lee HS,Kim KR,Chung WH,Cho YS,Hong SH

    更新日期:2008-12-01 00:00:00

  • Surgical Algorithm for Obstructive Sleep Apnea: An Update.

    abstract::Sleep surgery is part of a continuum of care for obstructive sleep apnea (OSA) that involves medical, pharmacologic, and behavioral therapy. Upper airway surgery for OSA can significantly improve stability by way of modulating the critical negative closing pressure. This is the same mechanism of action as positive air...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.21053/ceo.2020.01053

    authors: Liu SY,Riley RW,Yu MS

    更新日期:2020-08-01 00:00:00

  • Clinical results of atticoantrotomy with attic reconstruction or attic obliteration for patients with an attic cholesteatoma.

    abstract:OBJECTIVES:We aimed to investigate the clinical results of atticoantrotomy in patients with an attic cholesteatoma. METHODS:Ninety-eight ears in 98 patients were operated on using atticoantrotomy between October 2002 and December 2006. A retrospective review of the otology database (operative findings and methods, pos...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2009.2.1.39

    authors: Kim JH,Choi SH,Chung JW

    更新日期:2009-03-01 00:00:00

  • Surgical management of rhinosinusitis in onco-hematological patients.

    abstract:OBJECTIVES:In onco-hematological diseases, the incidence of paranasal sinuses infection dramatically increase and requires a combination of medical and surgical therapy. Balloon dilatation surgery (DS) is a minimally invasive, tissue preserving procedure. The study evaluates the results of DS for rhinosinusitis in immu...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2014.7.4.302

    authors: Di Girolamo S,Mazzone S,Di Mauro R,Giacomini P,Cantonetti M

    更新日期:2014-12-01 00:00:00

  • Exclusive Endoscopic Resection of Nasopharyngeal Papillary Adenocarcinoma via Combined Transnasal and Transoral Approach.

    abstract::Low grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is an extremely rare variant of nasopharyngeal cancer, which exhibits distinct clinicopathological characteristics. Surgical resection has been regarded as the principal treatment. For this, transpalatal or transfacial approach has been classically used for ex...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2013.6.1.48

    authors: Ryu J,Park WS,Jung YS

    更新日期:2013-03-01 00:00:00

  • The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro.

    abstract:OBJECTIVES:Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2018.00878

    authors: Moon BS,Ammothumkandy A,Zhang N,Peng L,Ibrayeva A,Bay M,Pratap A,Park HJ,Bonaguidi MA,Lu W

    更新日期:2018-12-01 00:00:00

  • Relationship Between Otorhinolaryngologic Diseases and Obesity.

    abstract:OBJECTIVES:Obesity rates have been increasing for all population groups worldwide, leading to the increased development of various diseases. This study was designed is to identify the relationships between obesity and several important otorhinolaryngologic diseases, including chronic otitis media (COM), chronic rhinosi...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.3.194

    authors: Kim TH,Kang HM,Oh IH,Yeo SG

    更新日期:2015-09-01 00:00:00