Abstract:
OBJECTIVES:The nuclear protein high mobility group protein box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of proinflammatory mediators, and it has recently emerged as a key player in different acute and chronic immune disorders. Several lines of evidence demonstrate that HMGB1 is actively released extracellularly from immune cells or passively released from necrotic cells. Because of the ability of HMGB1 to sustain chronic inflammation, we investigated whether the protein is present in nasal fluids of patients with different forms of rhinitis. METHODS:HMGB1 levels were evaluated in nasal fluids of healthy subjects or rhinitis patients who were treated or not treated with different treatments. RESULTS:We report that the level of HMGB1 was significantly increased in nasal fluids of patients with allergic rhinitis, patients with NARES (nonallergic rhinitis with eosinophiliac syndrome), as well as patients with polyps. We also found that a formulation containing the HMGB1-binding compound glycyrrhizin (GLT) reduced the HMGB1 content in nasal fluids of rhinitis patients to an extent similar to that with nasal budesonide treatment. We also found that among the cultured human leukocyte populations, eosinophils released higher amounts of HMGB1. Based on the ability of HMGB1 to sustain eosinophil survival and the ability of GLT to inactivate HMGB1, we report that GLT selectively killed cultured eosinophils and had no effect on neutrophils, macrophages, and lymphocytes. CONCLUSION:Collectively, these data underscore the role of HMGB1 in rhinitis pathogenesis and the therapeutic potential of GLT formulations in treatment of chronic inflammatory disorders of the nasal mucosa.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Cavone L,Cuppari C,Manti S,Grasso L,Arrigo T,Calamai L,Salpietro C,Chiarugi Adoi
10.3342/ceo.2015.8.2.123subject
Has Abstractpub_date
2015-06-01 00:00:00pages
123-8issue
2eissn
1976-8710issn
2005-0720journal_volume
8pub_type
杂志文章abstract:OBJECTIVES:Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) in Ménière's disease (MD) and to evaluate whether the VEMP results can be useful in assessing the stage of MD. Furthermore, we tried to evaluate the clinical effectiveness of VEMP in predicting hearing outcomes. ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.2.57
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:FOS-like antigen-2 (FOSL-2), a member of the FOS gene family, encode leucine zipper proteins that can heterodimerize with proteins of Jun family. Thus, activating protein (AP)-1 transcription factor is formed, has a crucial role in proliferation, differentiation and apoptosis of normal tissue as well as onco...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.1.42
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:Although many studies have assessed sudden deafness in adults, sudden deafness has not been evaluated in children. We therefore evaluated the differences in sudden deafness between children and adults. METHODS:We compared clinical manifestations, including gender, audiogram pattern of initial hearing loss, ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.3.165
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. METHODS:This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01368
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:Directional microphone technology can enhance the speech intelligibility and listening comfort of listeners with hearing impairment. The main aim of this study is to investigate and compare the benefit derived by listeners with severe hearing loss from directional microphone technology with that derived by l...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2017.01375
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:The transoral removal of stones by sialodochoplasty has been popularized in the treatment of submandibular sialolithiasis. However, the effectiveness of sialodochoplasty is controversial, and there are no reports on the long-term outcomes of this procedure. The purpose of this study was to assess the effecti...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.1.34
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:This study was conducted to investigate the current practices of Asian otolaryngologists for laryngopharyngeal reflux (LPR). METHODS:An online survey about LPR was sent to 2,000 members of Asian otolaryngological societies, and a subgroup analysis was performed between Western and Eastern Asian otolaryngolo...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.01669
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:This study prospectively evaluated postthyroidectomy syndrome (PTS) through objective and subjective voice changes following thyroidectomy of open vs. endoscopic thyroidectomy. METHODS:A prospective clinical trial (SCHBC IRB 09 26) was performed from Jan 2008 to Aug 2010 to compare the open thyroidectomy (O...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.1.76
更新日期:2015-03-01 00:00:00
abstract:Objectives:Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the local-regional advanced stage (stage IVa) but their treatment with upfront surgery vs. definite chemoradiation therapy (CRT) is controversial. The purpose of the present study is to compare overall survival (OS) and disease-free s...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.01732
更新日期:2020-09-25 00:00:00
abstract:OBJECTIVES:This study was to show the technique and to compare the usefulness and complications of biopsy using a minimal incision with a needle tip of the labial minor salivary glands with those of conventional incisional lip biopsy in the diagnosis of Sjögren's syndrome. METHODS:We retrospectively reviewed the medic...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.3.222
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association betwe...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.4.211
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:Laryngomicrosurgery (LMS) is used to manage most vocal fold lesions. However, the functional voice outcome of the LMS might be diverse due to the influence of various factors. We intend to evaluate the incidence and etiologic factors of persistent dysphonia after LMS for benign vocal fold disease (BVFD). ME...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.3.166
更新日期:2013-09-01 00:00:00
abstract::Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse e...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.3342/ceo.2014.7.4.241
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.S1.S6
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:The authors would report the results of definitive radiation therapy (RT) for early glottic cancer by two different radiation dose schedules. METHODS:From February of 1995 till June of 2008, 157 patients with T1-2N0 glottic cancer were treated with curative RT at Samsung Medical Center. All patients had squ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.2.94
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:Some changes are found in the labyrinth anatomy during postnatal development. Although the spatial orientation of semicircular canals was thought to be stable after birth, we investigated the age-related orientational changes of human semicircular canals during development. METHODS:We retrospectively studie...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2014.02012
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:In onco-hematological diseases, the incidence of paranasal sinuses infection dramatically increase and requires a combination of medical and surgical therapy. Balloon dilatation surgery (DS) is a minimally invasive, tissue preserving procedure. The study evaluates the results of DS for rhinosinusitis in immu...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.4.302
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To evaluate characteristic computed tomography (CT) and magnetic resonance (MR) imaging findings of granulocytic sarcomas of the head and neck. METHODS:The CT (n=11) and MR (n=1) images obtained from 11 patients (7 males and 4 females; mean age, 23.5 yr; age range, 1 to 69 yr) with histologically-proven gra...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2009.2.2.66
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:This study was conducted evaluate the efficacy of electromyography (EMG) using transcartilaginous (TC) electrodes through the thyroid cartilage and perichondrium. METHODS:We prospectively collected EMG data from intraoperative neuromonitoring (IONM) of 54 nerves at risk in 38 patients during thyroidectomy. ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.01529
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis. METHODS:Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patient...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.00395
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:To compare the velopharyngeal function, swallowing and speech of the conventional and modified radial forearm free flap (RFFF) for soft palate reconstruction. METHODS:Retrospective clinical study. Twenty-eight patients who underwent oropharyngeal reconstruction with RFFF were divided into two groups: 10 pat...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.3.161
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To compare voice parameters in subjects with different hearing level. METHODS:The evaluation consisted of Multi-Dimensional Voice Program (MDVP) and electroglottography. Group 1 consisted of normal hearing subjects which is bilateral average hearing better than 25 decibels (dB) whereas group 2 consisted of ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01900
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To evaluate efficacy of short term intranasal corticosteroid (mometasone furoate) treatment in pediatric sleep-disordered breathing (SDB) patients. METHODS:A prospective, observational study was done. A total of 41 children (2-11 years old) were enrolled into this study. All patients received 4-weeks course...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2011.4.1.27
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Autologous costal cartilage is a promising alternative for mastoid obliteration. However, donor-site morbidities of the chest wall limit the use of this graft. To address this issue, we have developed a minimally-invasive technique of harvesting costal cartilage and report donor site morbidity associated wit...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.1.13
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:The internet has become an important source of medical information and a great amount of information related to allergic rhinitis (AR) is available on the internet. However, the quality of this information is still a matter of debate. Therefore, this study was conducted to assess the AR-related information o...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.1.32
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:This study analyzed short-term prognosis in patients with acute low frequency hearing loss (ALHL), and also investigate hearing recovery rates in patients with ALHL accompanied vertigo. METHODS:Retrospective medical record review of the patients who received treatment for ALHL between June 2005 and June 201...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2017.00948
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.2.97
更新日期:2008-06-01 00:00:00
abstract::A schwannoma of the larynx is a rare benign tumor that usually presents as a submucosal mass in the pyriform sinus and the aryepiglottic space, and this type of schwannoma constitutes a diagnostic and therapeutic challenge for otolaryngologists. We present here two cases of supraglottic schwannomas that were misdiagno...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.3.166
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:Streptococcus pneumoniae is one of the most common pathogens of otitis media (OM) that exists in biofilm, which enhances the resistance of bacteria against antibiotic killing and diagnosis, compared to the free-floating (planktonic) form. This study evaluated biofilm formation by S. pneumoniae on an abiotic ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.3.139
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the effect of the presence of one or two arytenoids on early/late period swallowing-aspiration functions. METHODS:Supracricoid partial laryngectomy (SCPL) with the diagnosis of laryngeal cancer between 2012 and 2014 were retrospectively evaluated. The patients were categ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01837
更新日期:2017-12-01 00:00:00