Abstract:
OBJECTIVES:The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis. METHODS:Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patients with laryngeal carcinoma and 60 patients with vocal cord polyps. Expression of the serum PTTG1 levels relationship with the clinicopathological characteristics and prognosis were analyzed. RESULTS:In laryngeal carcinoma patients' serum, the PTTG1 median concentration was 141.43 pg/mL (interquartile range [IQR], 111.387 to 160.837 pg/mL), significantly higher than that of the vocal cord polyp group of 94.01 pg/mL (IQR, 81.26 to 108.59 pg/mL), and the difference was statistically significant (z=-6.715, P<0.001). PTTG1 expression with lymph node metastasis, clinical stage, and patients with laryngeal carcinoma was significantly correlated with the tumor differentiation degree (P<0.05). The total survival rate of the PTTG1 high expression group was significantly lower than the low expression group, and the difference of total survival time of the two groups was statistically significant (P<0.001). CONCLUSION:The PTTG1 expression level can be used as an index for evaluating prognosis of laryngeal cancer. High PTTG1 expression is one of the factors of poor prognosis of laryngeal carcinoma patients.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Ma K,Sun X,Ma L,Zhang Sdoi
10.21053/ceo.2019.00395subject
Has Abstractpub_date
2020-02-01 00:00:00pages
64-68issue
1eissn
1976-8710issn
2005-0720pii
ceo.2019.00395journal_volume
13pub_type
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更新日期:2013-12-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2008-06-01 00:00:00
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更新日期:2018-12-01 00:00:00
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doi:10.21053/ceo.2015.01690
更新日期:2017-03-01 00:00:00
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更新日期:2014-12-01 00:00:00
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doi:10.3342/ceo.2008.1.4.211
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...
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更新日期:2012-04-01 00:00:00
abstract::Meningioma's account for around 15% of all primary brain tumors with some 10% of meningiomas arising in the posterior fossa. In rare cases, a meningioma can form around the endolymphatic sac. When formed in the posterior fossa, meningioma tumors can produce vague, non-specific vertiginous symptoms. Research has observ...
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abstract:OBJECTIVES:FOS-like antigen-2 (FOSL-2), a member of the FOS gene family, encode leucine zipper proteins that can heterodimerize with proteins of Jun family. Thus, activating protein (AP)-1 transcription factor is formed, has a crucial role in proliferation, differentiation and apoptosis of normal tissue as well as onco...
journal_title:Clinical and experimental otorhinolaryngology
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doi:10.3342/ceo.2014.7.1.42
更新日期:2014-03-01 00:00:00
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更新日期:2020-11-04 00:00:00