Expression of Serum PTTG1 in Laryngeal Carcinoma and Its Correlation to Prognosis.

Abstract:

OBJECTIVES:The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis. METHODS:Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patients with laryngeal carcinoma and 60 patients with vocal cord polyps. Expression of the serum PTTG1 levels relationship with the clinicopathological characteristics and prognosis were analyzed. RESULTS:In laryngeal carcinoma patients' serum, the PTTG1 median concentration was 141.43 pg/mL (interquartile range [IQR], 111.387 to 160.837 pg/mL), significantly higher than that of the vocal cord polyp group of 94.01 pg/mL (IQR, 81.26 to 108.59 pg/mL), and the difference was statistically significant (z=-6.715, P<0.001). PTTG1 expression with lymph node metastasis, clinical stage, and patients with laryngeal carcinoma was significantly correlated with the tumor differentiation degree (P<0.05). The total survival rate of the PTTG1 high expression group was significantly lower than the low expression group, and the difference of total survival time of the two groups was statistically significant (P<0.001). CONCLUSION:The PTTG1 expression level can be used as an index for evaluating prognosis of laryngeal cancer. High PTTG1 expression is one of the factors of poor prognosis of laryngeal carcinoma patients.

authors

Ma K,Sun X,Ma L,Zhang S

doi

10.21053/ceo.2019.00395

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

64-68

issue

1

eissn

1976-8710

issn

2005-0720

pii

ceo.2019.00395

journal_volume

13

pub_type

杂志文章
  • The Clinical Manifestations and Chest Computed Tomography Findings of Coronavirus Disease 2019 (COVID-19) Patients in China: A Proportion Meta-Analysis.

    abstract:OBJECTIVES:The objectives of this study were to identify the clinical features and chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) patients and to compare the characteristics of patients diagnosed in Wuhan and in other areas of China by integrating the findings reported in previous studie...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2020.00570

    authors: Park JH,Jang W,Kim SW,Lee J,Lim YS,Cho CG,Park SW,Kim BH

    更新日期:2020-05-01 00:00:00

  • Evaluation of the protective effect of Beta glucan on amikacin ototoxicity using distortion product otoacoustic emission measurements in rats.

    abstract:OBJECTIVES:This experimental study investigated the possible protective effect of beta glucans on amikacin ototoxicity. METHODS:Thirty-eight rats with normal distortion product otoacoustic emissions (DPOAEs) were divided into four groups. Group K was the control group. Group A was injected intramuscularly (i.m.) with ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2013.6.1.1

    authors: Bayindir T,Filiz A,Iraz M,Kaya S,Tan M,Kalcioglu MT

    更新日期:2013-03-01 00:00:00

  • Perceptual and Acoustic Outcomes of Early-Stage Glottic Cancer After Laser Surgery or Radiotherapy: A Meta-Analysis.

    abstract::Laser surgery (LS) or radiotherapy (RT) is normally recommended in early glottic cancer. The objective of this study was to perform a comprehensive meta-analysis of acoustic and perceptual outcomes to compare voice quality of LS or RT in early-stage glottic cancer. Data sources were obtained after searching PubMed, Go...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.21053/ceo.2018.00990

    authors: Lee SH,Hong KH,Kim JS,Hong YT

    更新日期:2019-08-01 00:00:00

  • Clinical Value of Vestibular Evoked Myogenic Potential in Assessing the Stage and Predicting the Hearing Results in Ménière's Disease.

    abstract:OBJECTIVES:Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) in Ménière's disease (MD) and to evaluate whether the VEMP results can be useful in assessing the stage of MD. Furthermore, we tried to evaluate the clinical effectiveness of VEMP in predicting hearing outcomes. ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2013.6.2.57

    authors: Kim MB,Choi J,Park GY,Cho YS,Hong SH,Chung WH

    更新日期:2013-06-01 00:00:00

  • Testing a New Anticoagulation Method for Free Flap Reconstruction of Head and Neck Cancers.

    abstract:OBJECTIVES:Free flaps are widely used to reconstruct head and neck defects. Despite the improvement in the surgical techniques and the surgeons' experiences, flap failures still occur due to thrombotic occlusion after small vessels anastomosis. To reduce the possibility of flap loss as a result of thrombotic occlusion,...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01781

    authors: Karimi E,Ardestani SH,Jafari M,Hagh AB

    更新日期:2016-12-01 00:00:00

  • Voice Outcome in Patients Treated With Endoscopic Laryngopharyngeal Surgery for Superficial Hypopharyngeal Cancer.

    abstract:OBJECTIVES:Endoscopic laryngopharyngeal surgery (ELPS) is a minimally invasive transoral surgery that was developed to treat superficial larygo-pharyngeal cancer, in which a mucosal lesion is resected transorally while preserving deeper structures by subepithelial injection. The purpose of this retrospective study is t...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2016.9.1.70

    authors: Tateya I,Morita S,Ishikawa S,Muto M,Hirano S,Kishimoto Y,Hiwatashi N,Ito J

    更新日期:2016-03-01 00:00:00

  • Juvenile hyaline fibromatosis.

    abstract::Juvenile hyaline fibromatosis (JHF) is a rare, progressive autosomal recessive disease that's characterized by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions. We present here the case of a 2-yr-old boy with JHF along with a review of the relevant li...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2010.3.2.102

    authors: Park KT,Chang DY,Sung MW

    更新日期:2010-06-01 00:00:00

  • Clinical results of atticoantrotomy with attic reconstruction or attic obliteration for patients with an attic cholesteatoma.

    abstract:OBJECTIVES:We aimed to investigate the clinical results of atticoantrotomy in patients with an attic cholesteatoma. METHODS:Ninety-eight ears in 98 patients were operated on using atticoantrotomy between October 2002 and December 2006. A retrospective review of the otology database (operative findings and methods, pos...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2009.2.1.39

    authors: Kim JH,Choi SH,Chung JW

    更新日期:2009-03-01 00:00:00

  • In VitroStreptococcus pneumoniae Biofilm Formation and In Vivo Middle Ear Mucosal Biofilm in a Rat Model of Acute Otitis Induced by S. pneumoniae.

    abstract:OBJECTIVES:Streptococcus pneumoniae is one of the most common pathogens of otitis media (OM) that exists in biofilm, which enhances the resistance of bacteria against antibiotic killing and diagnosis, compared to the free-floating (planktonic) form. This study evaluated biofilm formation by S. pneumoniae on an abiotic ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.3.139

    authors: Yadav MK,Chae SW,Song JJ

    更新日期:2012-09-01 00:00:00

  • Assessment of allergic rhinitis websites in Korea.

    abstract:OBJECTIVES:The internet has become an important source of medical information and a great amount of information related to allergic rhinitis (AR) is available on the internet. However, the quality of this information is still a matter of debate. Therefore, this study was conducted to assess the AR-related information o...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2010.3.1.32

    authors: Chang MY,Han DH,Moon IJ,Kim ST,Kim DY,Lee CH,Min YG,Rhee CS

    更新日期:2010-03-01 00:00:00

  • Exclusive Endoscopic Resection of Nasopharyngeal Papillary Adenocarcinoma via Combined Transnasal and Transoral Approach.

    abstract::Low grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is an extremely rare variant of nasopharyngeal cancer, which exhibits distinct clinicopathological characteristics. Surgical resection has been regarded as the principal treatment. For this, transpalatal or transfacial approach has been classically used for ex...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2013.6.1.48

    authors: Ryu J,Park WS,Jung YS

    更新日期:2013-03-01 00:00:00

  • Definitive radiation therapy for early glottic cancer: experience of two fractionation schedules.

    abstract:OBJECTIVES:The authors would report the results of definitive radiation therapy (RT) for early glottic cancer by two different radiation dose schedules. METHODS:From February of 1995 till June of 2008, 157 patients with T1-2N0 glottic cancer were treated with curative RT at Samsung Medical Center. All patients had squ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.2.94

    authors: Kim TG,Ahn YC,Nam HR,Chung MK,Jeong HS,Son YI,Baek CH

    更新日期:2012-06-01 00:00:00

  • The Age-Related Orientational Changes of Human Semicircular Canals.

    abstract:OBJECTIVES:Some changes are found in the labyrinth anatomy during postnatal development. Although the spatial orientation of semicircular canals was thought to be stable after birth, we investigated the age-related orientational changes of human semicircular canals during development. METHODS:We retrospectively studie...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2014.02012

    authors: Lyu HY,Chen KG,Yin DM,Hong J,Yang L,Zhang TY,Dai PD

    更新日期:2016-06-01 00:00:00

  • Survival benefits from surgery of stage IVa head and neck squamous cell carcinoma: A multi-institutional analysis of 1033 cases.

    abstract:Objectives:Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the local-regional advanced stage (stage IVa) but their treatment with upfront surgery vs. definite chemoradiation therapy (CRT) is controversial. The purpose of the present study is to compare overall survival (OS) and disease-free s...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2020.01732

    authors: Park JO,Park YM,Jeong WJ,Shin YS,Hong YT,Choi IJ,Kim JW,Woo SH,Kim YS,Chang JW,Kim MS,Jung KY,Ahn SH,Kim CH,Hong KH,Chung PS,Kim YM,Kim SH,Baek SK

    更新日期:2020-09-25 00:00:00

  • Small-group counseling in a modified tinnitus retraining therapy for chronic tinnitus.

    abstract:OBJECTIVES:The authors have treated chronic tinnitus patients using a combination of a simplified tinnitus retraining therapy (TRT) and medications, which we called modified TRT. In this clinical setting, we have attempted small-group counseling to find a time-effective equivalent of individual counseling. The aim of t...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2013.6.4.214

    authors: Park SN,Bae SC,Kim DK,Park YS,Yeo SW,Park SY

    更新日期:2013-12-01 00:00:00

  • Swallowing and Aspiration: How Much Is Affected by the Number of Arytenoid Cartilages Remaining After Supracricoid Partial Laryngectomy?

    abstract:OBJECTIVES:The aim of this study was to compare the effect of the presence of one or two arytenoids on early/late period swallowing-aspiration functions. METHODS:Supracricoid partial laryngectomy (SCPL) with the diagnosis of laryngeal cancer between 2012 and 2014 were retrospectively evaluated. The patients were categ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01837

    authors: Kılıç C,Tunçel Ü,Kaya M,Cömert E,Özlügedik S

    更新日期:2017-12-01 00:00:00

  • Is Hypozincemia Related to Tinnitus?: A Population Study Using Data From the Korea National Health and Nutrition Examination Survey.

    abstract:OBJECTIVES:The aim of present study was to determine the relationship between serum zinc level and tinnitus using data from the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS:The present study examined the relationship between serum zinc level and tinnitus using data from the KNHANES. A tota...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.4.335

    authors: Jun HJ,Ok S,Tyler R,Hwang SY,Chae S

    更新日期:2015-12-01 00:00:00

  • Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure.

    abstract:OBJECTIVES:In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2015.8.4.390

    authors: Kucuk N,Sari M,Midi A,Yumusakhuylu AC,Findik O,Binnetoglu A

    更新日期:2015-12-01 00:00:00

  • The Acceptable Noise Level Benefit From Directionality for Listeners With Severe Hearing Loss.

    abstract:OBJECTIVES:Directional microphone technology can enhance the speech intelligibility and listening comfort of listeners with hearing impairment. The main aim of this study is to investigate and compare the benefit derived by listeners with severe hearing loss from directional microphone technology with that derived by l...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2017.01375

    authors: Aghsoleimani M,Jalilvand H,Mahdavi ME,Nazeri AR,Kamali M

    更新日期:2018-09-01 00:00:00

  • Functional benefit after modification of radial forearm free flap for soft palate reconstruction.

    abstract:OBJECTIVES:To compare the velopharyngeal function, swallowing and speech of the conventional and modified radial forearm free flap (RFFF) for soft palate reconstruction. METHODS:Retrospective clinical study. Twenty-eight patients who underwent oropharyngeal reconstruction with RFFF were divided into two groups: 10 pat...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2008.1.3.161

    authors: Kim JH,Chu HR,Kang JM,Bae WJ,Oh SJ,Rho YS,Ahn HY,Jung CH

    更新日期:2008-09-01 00:00:00

  • Development of a Novel Intraoperative Neuromonitoring System Using a Surface Pressure Sensor to Detect Muscle Movement: A Rabbit Model Study.

    abstract:OBJECTIVES:False-negative or false-positive responses in intraoperative neuromonitoring (IONM) using electromyography (EMG) in thyroid surgery pose a challenge. Therefore, we developed a novel IONM system that uses a surface pressure sensor instead of EMG to detect muscle twitching. This study aimed to investigate the ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2018.01207

    authors: Sung ES,Lee JC,Shin SC,Kwon HG,Kim MS,Kim DJ,Ro JH,Lee BJ

    更新日期:2019-05-01 00:00:00

  • Detection of MAGE and SSX gene expressions by RT-nested PCR using common primers in head and neck cancer.

    abstract:OBJECTIVES:The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2008.1.2.97

    authors: Song DW,Shin SJ,Kim DE,Jung SG,Park JW,Lee KD

    更新日期:2008-06-01 00:00:00

  • Immunotherapy in Head and Neck Squamous Cell Cancer.

    abstract::Prognosis in relapsed metastatic head and neck squamous cell cancer (RM-HNSCC) is dismal. Platinum based chemotherapy in combination with Cetuximab is used in first-line setting, while no further validated options are available at progression. Immunotherapy has produced durable clinical benefit in some patients with R...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2018.00150

    authors: Denaro N,Merlano MC

    更新日期:2018-12-01 00:00:00

  • A Trainable Hearing Aid Algorithm Reflecting Individual Preferences for Degree of Noise-Suppression, Input Sound Level, and Listening Situation.

    abstract:OBJECTIVES:In an effort to improve hearing aid users' satisfaction, recent studies on trainable hearing aids have attempted to implement one or two environmental factors into training. However, it would be more beneficial to train the device based on the owner's personal preferences in a more expanded environmental aco...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2015.01690

    authors: Yoon SH,Nam KW,Yook S,Cho BH,Jang DP,Hong SH,Kim IY

    更新日期:2017-03-01 00:00:00

  • Sublingual immunotherapy in allergic rhinitis: efficacy, safety, adherence and guidelines.

    abstract::Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse e...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.3342/ceo.2014.7.4.241

    authors: Aboshady OA,Elghanam KM

    更新日期:2014-12-01 00:00:00

  • Early sensorineural hearing loss in ob/ob mouse, an animal model of type 2 diabetes.

    abstract:OBJECTIVES:There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association betwe...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2008.1.4.211

    authors: Lee HS,Kim KR,Chung WH,Cho YS,Hong SH

    更新日期:2008-12-01 00:00:00

  • Auditory Evoked Potentials under Active and Passive Hearing Conditions in Adult Cochlear Implant Users.

    abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.S1.S6

    authors: Obuchi C,Harashima T,Shiroma M

    更新日期:2012-04-01 00:00:00

  • A posterior petrous meningioma with recurrent vertigo.

    abstract::Meningioma's account for around 15% of all primary brain tumors with some 10% of meningiomas arising in the posterior fossa. In rare cases, a meningioma can form around the endolymphatic sac. When formed in the posterior fossa, meningioma tumors can produce vague, non-specific vertiginous symptoms. Research has observ...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2012.5.4.234

    authors: Choi SJ,Lee JB,Bae JH,Yoon JH,Lee HJ,Kim CH,Park K,Choung YH

    更新日期:2012-12-01 00:00:00

  • Association Study of FOS-Like Antigen-2 Promoter Polymorphisms With Papillary Thyroid Cancer in Korean Population.

    abstract:OBJECTIVES:FOS-like antigen-2 (FOSL-2), a member of the FOS gene family, encode leucine zipper proteins that can heterodimerize with proteins of Jun family. Thus, activating protein (AP)-1 transcription factor is formed, has a crucial role in proliferation, differentiation and apoptosis of normal tissue as well as onco...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.3342/ceo.2014.7.1.42

    authors: Kim SW,Kim CD,Chung JH,Kwon KH

    更新日期:2014-03-01 00:00:00

  • Long-term Clinical Course of Benign Fibro-osseous Lesions in the Paranasal Sinuses.

    abstract:Objectives:Fibro-osseous lesions of the paranasal sinuses can present various clinical conditions. This study aimed to report the long-term clinical course of benign fibro-osseous lesions (BFOLs) in the paranasal sinuses, including clinical and radiologic features. Methods:Radiologically confirmed BFOLs except osteoma...

    journal_title:Clinical and experimental otorhinolaryngology

    pub_type: 杂志文章

    doi:10.21053/ceo.2020.01522

    authors: Lee JJ,Ryu G,Lee KE,Hong SD,Jung YG,Kim HY,Dhong HJ,Chung SK

    更新日期:2020-11-04 00:00:00