Abstract:
:Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse effects were recorded including anaphylaxis. In 1986, sublingual immunotherapy (SLIT) was introduced as an alternative solution to solve this problem. Our study aims to discuss SLIT from the points of efficacy, safety, adherence and guidelines developed. A literature search was conducted in Medline/PubMed and the Cochrane Library in January 2013 using the keywords "allergic rhinitis, sublingual immunotherapy, efficacy, safety, compliance, adherence, guidelines." All types of publications were included. We augmented our study by searching the reference lists of identified reviews. SLIT has been established in many guidelines as an evidence-based effective treatment in AR with safer profile than SCIT. The meta-analyses confirmed its efficacy and showed a significant reduction in both symptoms and medication scores. The most common recorded adverse effects were minor local effects in the mouth, gastrointestinal reactions with few cases of anaphylaxis and no fatality. Adherence is more favorable for SLIT mainly because it is safe, noninvasive and easily taken at home. We support the call to conduct large multi-centric studies to gain more statistical power and overcome the problem of heterogeneity observed in the meta-analyses.
journal_name
Clin Exp Otorhinolaryngoljournal_title
Clinical and experimental otorhinolaryngologyauthors
Aboshady OA,Elghanam KMdoi
10.3342/ceo.2014.7.4.241subject
Has Abstractpub_date
2014-12-01 00:00:00pages
241-9issue
4eissn
1976-8710issn
2005-0720journal_volume
7pub_type
杂志文章,评审abstract:OBJECTIVES:Vertebrobasilar dolichoectasia (VBD), an elongation and distension of vertebrobasilar artery, may present with cranial nerve symptoms due to nerve root compression. The objectives of this study are to summarize vestibulocochlear manifestations in subjects with VBD through a case series and to discuss the nee...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.00780
更新日期:2020-05-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2017.01221
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:Patients with bilateral vocal fold paralysis (BVFP) theoretically have difficulty producing voiceless consonants. However, perceptual studies have revealed clear production of voiceless consonants with good articulation scores in nontracheostomized patients. The purpose of this study was to clarify the produ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2016.00626
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To compare voice parameters in subjects with different hearing level. METHODS:The evaluation consisted of Multi-Dimensional Voice Program (MDVP) and electroglottography. Group 1 consisted of normal hearing subjects which is bilateral average hearing better than 25 decibels (dB) whereas group 2 consisted of ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01900
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:The primary aim of this study was to determine whether 18F-FDG-PET/CT (PET/CT) scans provide additional diagnostic information in addition to the direct laryngoscopic examination (L/E) and contrast-enhanced CT (CT) in patients with glottic cancer during the initial evaluation. METHODS:Fifty-five consecutive...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.1.35
更新日期:2008-03-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2014.02012
更新日期:2016-06-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.4.214
更新日期:2013-12-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2011.4.1.27
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Directional microphone technology can enhance the speech intelligibility and listening comfort of listeners with hearing impairment. The main aim of this study is to investigate and compare the benefit derived by listeners with severe hearing loss from directional microphone technology with that derived by l...
journal_title:Clinical and experimental otorhinolaryngology
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doi:10.21053/ceo.2017.01375
更新日期:2018-09-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.1.13
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:The prognostic significance of vertigo in patients with idiopathic sudden sensorineural hearing loss (SSNHL) remains a matter of debate because vertigo is associated with many different vestibular disorders. The purpose of this study is to determine the role of benign paroxysmal positional vertigo (BPPV) as ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.4.199
更新日期:2010-12-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.3.161
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:We analyzed the outcomes following clinical management of parotid masses that were determined to be malignant tumors after parotidectomy. METHODS:We evaluated data from 70 patients with parotid malignancies between November 1994 and December 2005. RESULTS:Among salivary histotypes (n=49), the most signific...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2014.7.2.126
更新日期:2014-06-01 00:00:00
abstract::Laser surgery (LS) or radiotherapy (RT) is normally recommended in early glottic cancer. The objective of this study was to perform a comprehensive meta-analysis of acoustic and perceptual outcomes to compare voice quality of LS or RT in early-stage glottic cancer. Data sources were obtained after searching PubMed, Go...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.21053/ceo.2018.00990
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The aim of present study was to determine the relationship between serum zinc level and tinnitus using data from the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS:The present study examined the relationship between serum zinc level and tinnitus using data from the KNHANES. A tota...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.4.335
更新日期:2015-12-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.01907
更新日期:2020-12-18 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2008.1.2.97
更新日期:2008-06-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2018.00878
更新日期:2018-12-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2010.3.1.32
更新日期:2010-03-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2015.8.1.76
更新日期:2015-03-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.2.57
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Speech perception abilities, which vary widely among cochlear implant (CI) users, are considered to be associated with the integrity of the central auditory pathways from the auditory nerve to the cortex. Therefore, auditory evoked potentials (AEPs) are used to evaluate central auditory processing, which is ...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2012.5.S1.S6
更新日期:2012-04-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.1.1
更新日期:2013-03-01 00:00:00
abstract:Objectives:Although unilateral hearing loss (UHL) has been proven to be associated with educational and behavioral problems, few studies have investigated psychopathological abnormalities in this population. The aim of this study was to evaluate the psychopathological influence of UHL among Korean 19-year-old males. M...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.00283
更新日期:2020-07-27 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2019.00402
更新日期:2020-02-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.3342/ceo.2013.6.1.48
更新日期:2013-03-01 00:00:00
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journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2020.01732
更新日期:2020-09-25 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. METHODS:This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章
doi:10.21053/ceo.2015.01368
更新日期:2016-09-01 00:00:00
abstract::Granulomatosis with polyangiitis (GPA) is an idiopathic vasculitis of medium and small arteries, characterized by necrotizing granulomatous inflammation. GPA typically affects upper and lower respiratory tract with coexisting glomerulonephritis. This disease is generally characterized by antineutrophil cytoplasm antib...
journal_title:Clinical and experimental otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.21053/ceo.2016.9.1.8
更新日期:2016-03-01 00:00:00