[The effect of bevacizumab on the ultrastructure of choroidal neovascular membranes in patients with age-related macular degeneration (AMD)].

Abstract:

BACKGROUND:Age-related macular degeneration (AMD) is a disease with high social impact that severely hinders the quality of life of the affected patients. The aim of our study is to examine the ultrastructural changes in the choroidal neovascular membranes occurring after the intravitreal administration of Avastin. MATERIAL AND METHODS:In our study we enrolled 24 AMD patients. Only 9 of them were treated with intravitreal injections of Bevacizumab (1.25 mg). Later on in all cases due to complications of the disease pars plana vitrectomy with excision of the subretinal membranes was performed. The subretinal membranes taken directly from the eye during the operation have been studied by transmission and scanning electron microscopy and with Safranin O. RESULTS:Subretinal membranes in AMD patients consisted mainly of fibroblasts, isolated or grouped RPE cells and elements of blood. Numerous capillaries of subretinal blood vessels were also found. Their walls consisted only of one thin layer of fenestrated endothelial cells. The endothelial fenestration in the Avastin-treated patients was significantly reduced. Densely packed thrombocytes and erythrocytes occluded the capillary lumen. Some of the RPE cells showed alterations. The number of proteoglycan complexes in the matrix was significantly increased. CONCLUSION:Our results indicate that intraviterally administered Avastin causes changes in the new vessel walls and in the extracellular matrix components. It diminishes the fenestration of the endothelial cells but also increases the risk of vessel occlusions and may have an alterating effect on the RPE cells. Although Avastin has the potential to improve the quality of life, patients subjected to the treatment should be carefully selected and constantly monitored.

journal_name

Klin Monbl Augenheilkd

authors

Vidinova C,Vidinov N

doi

10.1055/s-0028-1109429

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

491-5

issue

6

eissn

0023-2165

issn

1439-3999

journal_volume

226

pub_type

临床试验,杂志文章
  • [Torsional shift operation, a tool in complete early childhood strabismus].

    abstract::By means of torsional shift operation, or "rotatory Kestenbaum procedure" - in which both ocular bulbs are rotated to the side to which the head is inclined - head malpostures can be eliminated or alleviated in three out of four cases. This applies both to the smaller group of patients with true nystagmus compensation...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050307

    authors: de Decker W,Conrad HG

    更新日期:1988-12-01 00:00:00

  • [The clinical course of an embolism of a branch of the retinal artery (author's transl)].

    abstract::The way in which a varying amount of blood runs past an almost obliterating yellowish-grey, homogenous "embolus" in a branch of the artery is shown. Finally although the "embolus" remained, there was an almost normal blood flow in amount. Retinal arteries running downwards showed changing vascular spasms, sometimes a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Pau H

    更新日期:1978-09-01 00:00:00

  • [Notes on a modification of Cüpper's Faden operation (the "false faden") (author's transl)].

    abstract::A "false faden operation was performed in 13 cases. In contrast to Cüpper's faden operation it had no lasting effect. The results of other authors were not confirmed. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Kaufmann H

    更新日期:1981-03-01 00:00:00

  • [Lidloading and intraocular pressure].

    abstract:BACKGROUND:Implantation of rigid gold or platinum lid weights (lidloading) represents the most common method for therapy of patients with lagophthalmus as a result of facial palsy. In a more recent approach also flexible platinum chains have been used. Glaucoma has frequently been described as a contraindication for li...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2004-813940

    authors: Schrom T,Habermann A,Wernecke K,Scherer H,Duncker G

    更新日期:2005-01-01 00:00:00

  • [Experiences with the implantation of anterior chamber lenses (author's transl)].

    abstract::On account of the good results with the new generation of anterior chamber lenses reported by C.D. Binkhorst, the implantation of lenses was begun in 1969 at the Department of Ophthalmology in Bremen and 350 anterior chamber lenses were implanted till 1st Febr. 1977. After the presentation of indications and the opera...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:

    authors: Draeger J,Koudelka A,Modzanowski P

    更新日期:1978-03-01 00:00:00

  • [Scotoma in the binocular field of vision in severe amblyopia and microstrabismus (author's transl)].

    abstract::Binocular perimetry with Aulhorn's Phase difference haploscope is described. Of 62 patients with primary micro-squint, 21 patients showed no scotoma, 15 patients showed a fixation or zero point scotoma of 0.5-1 degrees, 26 patients showed a larger scotoma (average: 3.7 degrees). In addition, 15 patients with larger an...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Lang J

    更新日期:1978-10-01 00:00:00

  • [Anti VEGF Therapy Under Real-Life Conditions: Adherance Determines Long Term Outcome in Neovascular AMD].

    abstract:BACKGROUND:Data from real-life studies on neovascular AMD (nvAMD) generally fall significantly behind respective data from interventional prospective trials. This can be attributed at least partially to differences in patient cohorts concerning both stages of AMD (including consecutive scarring or atrophy), as well as ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0041-107672

    authors: Sachs HG,Wilke RG

    更新日期:2016-08-01 00:00:00

  • [Local anesthetic effect and subjective tolerance of a single dose of 0.25% bupranolol in probands with healthy eyes. Randomized parallel double-blind study].

    abstract::.25% Bupranolol in an oily solution decreases corneal sensitivity statistically significant from the 3. to the 15. minute after the application. The maximum of decrease is found between the 6. and the 15. minute in contrast to beta-blockers in aqueous solution (1.-3. minute). The topical subjective compatibility of 0....

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2008-1045923

    authors: Bastian B,Höh H

    更新日期:1991-01-01 00:00:00

  • [Epibulbar osteomas (author's transl)].

    abstract::Epibulbar osteomas are benign tumors which are usually present at birth. Up to now 39 cases have been described in the literature. In the last three years 4 further cases have been found in the Freiburg, Hamburg, Marburg, and Munich University Eye Clinics. Epibulbar osteomas probably occur more often than is generally...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057467

    authors: Bujara K,Stefani FH,Strempel I,Witschel H

    更新日期:1980-03-01 00:00:00

  • [Echographic findings in choroidal detachment].

    abstract::A- and B-scan sonography was performed in 83 patients with choroidal detachment; a serous choroidal detachment is characterized by high, bifurcated echospikes and an echo-free subchoroidal space in A-scan sonography. The B-scan presents a typical arc shape. In hemorrhagic choroidal detachment multiple echoes with low ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054708

    authors: Rochels R,Hackelbusch R

    更新日期:1983-01-01 00:00:00

  • Contact Lenses in the Management of Corneal Dystrophies.

    abstract::Among the group of diseases comprising corneal dystrophies, there are a number for which contact lenses may be considered. For example, soft contact lenses may be beneficial in the management of recurrent corneal erosions and advanced bullous keratopathy and may lead to disease attenuation in some conditions. They als...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/a-0735-9801

    authors: Farooq AV,Colby K

    更新日期:2020-02-01 00:00:00

  • [Aldose-reductase inhibitors and cataract formation (author's transl)].

    abstract::Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes. We have tested the inhibitory activity of new flavone derivatives on a homogenate of lens epithelium. Compounds which inhibited the enzyme activity by more than 50 percent at 10(-60) M were then t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057488

    authors: Keller G,Leuenberger PM

    更新日期:1980-04-01 00:00:00

  • [Electroophthalmological characteristics in ischemic retinopathy (author's transl)].

    abstract::In the ERG the b-wave and the oscillatory potentials are reduced or nonrecordable in ischemic retinopathy. The photopic b-wave appeared to be more sensitive than the scotopic b-wave. In the EOG the slow oscillation is reduced. These clinical observations are in accordance with the results of experimental studies in rh...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Heilig P,Thaler A,Kolder HE,Hayreh SS,Snyder JE

    更新日期:1979-03-01 00:00:00

  • [Treatment of central retinal venous and arterial occlusion by isovolemic hemodilution (author's transl)].

    abstract::(1) Ten patients (mean age 71) with fully developed central retinal venous occlusion were treated by isovolemic hemodilution over a period of four to six weeks. Hematocrit was lowered in steps to about 30% to improve retinal microcirculation. For two to four days, 500 ml whole blood were exchanged daily for about 250 ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057628

    authors: Wiederholt M,Leonhardt H,Schmid-Schönbein H,Hager H

    更新日期:1980-01-01 00:00:00

  • [Corneal endothelial damage in congenital and juvenile glaucoma].

    abstract::Corneal changes are typical for infantile glaucoma. In newborns, Descemet's membrane and the stroma are still soft, and distend when intraocular pressure rises. Cell counts were performed under the reflecting microscope to determine whether the endothelium is affected when corneal diameter increases and changes occur ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050052

    authors: Wenzel M,Krippendorff U,Hunold W,Reim M

    更新日期:1989-12-01 00:00:00

  • [Concerning the Toti operative procedure (author's transl)].

    abstract::It has been shown by a series of 127 dacryocystorhinostomies using the Toti technique, that this operation, which is independent of age or aethiology, can be performed using a simple procedure and a short hospitalization time. The success rate of over 90% indicates that this operation should be used as a standard proc...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Brewitt H,Huerkamp B

    更新日期:1979-02-01 00:00:00

  • [Familial cataract in plasma galactitol increase without known enzyme defect].

    abstract:BACKGROUND:Several enzyme defects of the galactose pathway may lead to cataract formation. We report on a family with familiar cataract. PATIENTS:A 2-year-old Turkish girl (daughter of first cousins) presented with dense cortical and subcapsular opacifications and mature cataract respectively. Bilateral phacectomy, pl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034710

    authors: Budde M,Gusek-Schneider GC,Jünemann A,Jansen F,Shin YS

    更新日期:1999-10-01 00:00:00

  • [Simulation of anterior ischemic optic neuropathy by optic nerve sheath meningioma].

    abstract:BACKGROUND:The optic nerve sheath meningioma usually presents with a diffuse atrophy of the disc and a diffuse depression of the visual field. Applying this rule too rigidly can lead to a false diagnosis. PATIENT:A 45y-old-woman presented with atrophy of the upper disc and a corresponding altitudinal field defect in h...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035368

    authors: Guhlmann M,Kommerell G

    更新日期:1995-09-01 00:00:00

  • [Observations on cataract incision dehiscence (author's transl)].

    abstract::24 patients with rupturing corneal incisions were observed within 6 years from 1971 until 1976. 19 patients had already had cataract extractions performed by us. This complication occurred in 0.5% of cases. All ruptures were investigated regarding the period of time after the cataract extraction, and possible precipit...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Bleckmann H

    更新日期:1977-05-01 00:00:00

  • [Contributions to the surgical technique of external dacryocystorhinostomy (author's transl)].

    abstract::The authors describe some modifications of the surgical technique of external dacryocystorhinostomy. The preliminary exploration methods and their evaluation are considered. An arched skin incision is used for a more anatomical dissection to approach the lacrimal sac. The following bone trepanation is then made with b...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Menezo JL,Francés J,Suárez R

    更新日期:1975-01-01 00:00:00

  • [Possibilities of microsurgery on ophthalmic vessels (author's transl)].

    abstract::Ciliary arteries, isolated from the eyes of human cadavers, were incised or severed under the microscope in order to test the technical possibilities of placing sutures or creating leak-proof anastomoses in ophthalmic vessels. Commercially available, minute atraumatic needles and 10-0 "Ethilon" or 15-0 Supramid suture...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057589

    authors: Gundorowa RA,Galtschin AS

    更新日期:1980-06-01 00:00:00

  • [Sturge-Weber syndrome: glaucoma with elevated episcleral venous pressure].

    abstract::The present report describes clinical findings in 13 patients with Sturge-Weber syndrome, 11 of whom had glaucoma (22-52 mm Hg). The episcleral venous pressure (EVP) was high in all glaucomatous eyes (14-23 mm Hg). Tonography showed a marked decrease in outflow facility. The observations suggest that glaucoma in Sturg...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050508

    authors: Jørgensen JS,Guthoff R

    更新日期:1987-10-01 00:00:00

  • [Histologic and ultrastructural findings in the ciliary ganglion in normal eyes and in patients with glaucoma].

    abstract::The histological and ultrastructural findings in the ciliary ganglion of glaucomatous patients show proliferation of the satellite cells, vacuolate degeneration of the cytoplasma with loss of the mitochondria and ergastoplasma, and necrosis of the nucleus with decrease of chromatin. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050838

    authors: Faschinger C,Kleinert K

    更新日期:1986-11-01 00:00:00

  • [The effect of the corneal epithelium on the biosynthesis of keratin sulphate in the stroma with regard to curvature variations important for wearing contact lenses (author's transl)].

    abstract::Intact or denuded bovine corneas were incubated in the presence of 14lC GlcN and parts of the proteoglycan-glycoprotein complexes of the stroma were extracted by 0.15M NaCl and successively by 1.0M CaCl2. The specific activities of total GAG and KS were determined. In the presence of the epithelial layer the biosynthe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Cremer-Bartels G

    更新日期:1977-12-01 00:00:00

  • [Inflammatory glaucomas].

    abstract::The prevalence of glaucoma in patients with intra- or extraocular inflammation is five to twenty percent. The etiopathogenesis is manifold, including classical secondary open and closed angle mechanisms as well as specific inflammatory elements. Diagnosis and follow-up studies of inflammatory glaucomas are often diffi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-858310

    authors: Grüb M,Deuter CM,Zierhut M

    更新日期:2005-10-01 00:00:00

  • [Local anesthesia with accidental perforation of the eye--an acute emergency?].

    abstract::A report on 3 instances of accidental injection of lidocaine into the eye. Among the immediate reactions were (1) development of corneal edema due to an abrupt rise in intraocular pressure, (2) dilatation and paralysis of the pupil, (3) decrease of visual acuity to light perception. In 2 of the patients pupillary reac...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050595

    authors: Lincoff H,Kreissig I

    更新日期:1986-02-01 00:00:00

  • [Near heterophoria with a description of the heterometer].

    abstract::The examination of near heterophoria with a heterometer using a large series of test plates presented "free-sighted" (i.e., not hindered by optical or mechanical means) enables a more comprehensive analysis to be made than has so far been achieved with other instruments. The principal components of the instruments are...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050156

    authors: Littan KE

    更新日期:1988-05-01 00:00:00

  • [Are prism glasses a sensible measure in treatment of dyslexia?].

    abstract::A short summary of the characteristics of speaking, reading and writing is given, followed by the respective anatomical, physiological and neuropsychological counterparts, which are to be described as the "Hör-Denk-Sprech-Seh-Schreib-Organismus" (H-D-S-S-SCH-O). Various disorders occurring in the H-D-S-S-SCH-O as well...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045842

    authors: Schwarz C

    更新日期:1992-05-01 00:00:00

  • [Melatonin biosynthesis in the mammalian retina in dependence of light adaptation (author's transl)].

    abstract::1. The biosynthesis of melatonin was investigated in retinaextracts of bovine eyes in dependence of light adaptation of the animals. S-adenososyl (Methyl-14C) methionin and acetylserotonin were used as substrates. A higher melatonin-biosynthesis was found in the retina from animals which were adapted to lower illumina...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Cremer-Bartels G,Hollwich F,Kotulla W

    更新日期:1975-07-01 00:00:00

  • [Valuation aetiology of venous retinal anastomotic vessels (author's transl)].

    abstract::Description of an aspect of a disease characterized by marked retinal venous anastomotic vessels in a 69-year-old man. There is no recognition of blindness of patients left eye and a declared trauma of war. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Huismans H

    更新日期:1977-05-01 00:00:00