When is serum albumin worth measuring?

abstract：:Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate...

journal_title：Annals of clinical biochemistry

authors： Pecoraro V,Banfi G,Germagnoli L,Trenti T

更新日期：2017-07-01 00:00:00

abstract：:During incubation with rabbit blood in vitro rabbit-muscle lactate dehydrogenase-5 was inactivated at a rate similar to that observed in vivo. By contrast plasma and plasma containing erythrocytes had no effect on the enzyme activity, but plasma containing leucocytes inactivated the enzyme at the same rate as whole bl...

journal_title：Annals of clinical biochemistry

authors： Qureshi AR,Wilkinson JH

更新日期：1977-01-01 00:00:00

abstract：:The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56 degrees C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for alpha-1-antitrypsin, beta-2-microglobulin, IgE, fibrinogen,...

journal_title：Annals of clinical biochemistry

authors： Gleeson M,Herd L,Burns C

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Glycated haemoglobin (HbA1c) concentration is lower relative to glyacemic control in diabetic patients on haemodialysis. However, it is unknown as to whether this is also true for diabetic patients with end-stage renal disease but not on haemodialysis. METHODS:Correlations between HbA1c or glycated albumin ...

journal_title：Annals of clinical biochemistry

authors： Shima K,Chujo K,Yamada M,Komatsu M,Noma Y,Mizuguchi T

更新日期：2012-01-01 00:00:00

abstract：:Fasting glycosylated haemoglobin was analysed in 535 consecutive patients having an oral 75 g glucose tolerance test for diagnostic purposes. A reference range for fasting glycosylated haemoglobin was established from patients with a non-diabetic glucose tolerance test as defined by the World Health Organisation Exper...

journal_title：Annals of clinical biochemistry

authors： Albutt EC,Nattrass M,Northam BE

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Current practice requires regular venous blood samples for monitoring of tacrolimus concentrations post renal transplant requiring regular hospital visits. Mitra devices use volumetric absorptive microsampling technology and absorb a fixed amount of blood (10 μL) from a capillary blood sample. They are a via...

journal_title：Annals of clinical biochemistry

authors： Marshall DJ,Kim JJ,Brand S,Bryne C,Keevil BG

更新日期：2020-09-01 00:00:00

abstract：:Gestational diabetes is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating gestational diabetes improves maternal and fetal outcomes and allows for health promotion to reduce the mo...

journal_title：Annals of clinical biochemistry

authors： Meek CL

更新日期：2017-01-01 00:00:00

abstract：:A microtiter plate based Dual Analyte enzyme-immunoassay method for the simultaneous measurement of alpha-fetoprotein (AFP) and Free-beta human chorionic gonadotrophin (hCG) was evaluated. This rapid assay, which has application in both Neural Tube Defect screening and Down's screening, shows good precision with betwe...

journal_title：Annals of clinical biochemistry

authors： Macri JN,Spencer K,Anderson R

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is an important but under-recognized condition. Recent national guidelines have recommended that biochemistry laboratories report estimated GFR (eGFR) to improve diagnosis of CKD and facilitate disease staging and management. Previous reports have suggested that intake of large a...

journal_title：Annals of clinical biochemistry

authors： Preiss DJ,Godber IM,Lamb EJ,Dalton RN,Gunn IR

更新日期：2007-01-01 00:00:00

abstract：:A comparison of the Roche Cobas Core and Hybritech TANDEM-E PSA (prostate specific antigen) assays revealed a large difference in the reactivity of each assay to the separated free and complexed forms of serum PSA in patients with prostatic carcinoma. The Roche assay was relatively much more responsive to the free for...

journal_title：Annals of clinical biochemistry

authors： Tillyer CR,Konings M,Gobin PT,Iqbal J

更新日期：1994-09-01 00:00:00

abstract：:The activity of serum deoxycytidylate deaminase, not hitherto reported to increase after myocardial infarction, has been investigated and the results have been related to other cardiac enzymes, including the MB fraction of creatine phosphokinase. Deoxycytidylate deaminase was found to increase to maximum activity on t...

journal_title：Annals of clinical biochemistry

authors： Roberts RG,Davies AG,Jones DD

更新日期：1978-11-01 00:00:00

abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...

journal_title：Annals of clinical biochemistry

authors： Kind CN

更新日期：1988-05-01 00:00:00

abstract：:A rapid and simple method for detecting circulating immune complexes based on turbidity measurements following polyethylene glycol precipitation was studied with regard to its suitability as a routine assay in clinical laboratories. This method was found to have an acceptable degree of precision provided the temperatu...

journal_title：Annals of clinical biochemistry

authors： Kilpatrick DC,Weston J,Irvine WJ

更新日期：1981-11-01 00:00:00

abstract：:Seventeen laboratories in the British Isles participated in a study to compare six different commercially available immunoassays for serum lipoprotein(a) (Lp(a)) and to establish reasons for the variations in the measurement of serum Lp(a) concentrations. Pooled serum was distributed neat and after dilution at a centr...

journal_title：Annals of clinical biochemistry

authors： Mackness MI,Bhatnagar D,Weiringa G,MBewu A,Haynes B,Durrington PN

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:To investigate the reasons why general practitioners (GPs) request rheumatoid factor (RF) assays, we studied 200 consecutive requests for RF from general practice in 1995. METHOD:By means of an audit questionnaire, we studied 100 negative, 50 positive and 50 borderline RF results and compared these with the...

journal_title：Annals of clinical biochemistry

authors： Sinclair D,Hull RG

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：:Study of the glycoprotein hormones, including hCG, is complex and evolving, and has benefited from recent major advances in analytical technology and molecular biology. It is important to be aware of the effect that these technological advances have, both on the analytical and the clinical requirements for provision o...

journal_title：Annals of clinical biochemistry

authors： Sturgeon CM,McAllister EJ

更新日期：1998-07-01 00:00:00

abstract：:A sensitive immunochemiluminometric assay with a detection limit of 1.1 microU/L was developed for the measurement of urinary growth hormone (UGH). The assay was shown to be specific and precise. There was a good correlation between serum growth hormone (GH) and UGH concentrations in 20 patients with acromegaly and si...

journal_title：Annals of clinical biochemistry

authors： Turner G,Brown RC,Weeks I,Butler GE,Creagh FN,Woodhead JS

更新日期：1993-03-01 00:00:00

abstract：:Four hundred and fifty-four subjects with hyperamylasaemia were screened for the presence of macroamylase using polyethylene glycol precipitation (PEG) and the Beckman automated amylase assay based on the hydrolysis of maltotetraose. Twenty-five subjects (5.5%) exhibited PEG precipitation values suggestive of macroamy...

journal_title：Annals of clinical biochemistry

authors： Lawson GJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The high-dose hook effect is a well-known phenomenon of two-site immunoassays including those for human chorionic gonadotrophin (hCG). We investigated the occurrence of a high-dose hook effect in six routinely available hCG assays using a sample with a total hCG concentration of approximately 3,600,000 IU/L....

journal_title：Annals of clinical biochemistry

authors： Al-Mahdili HA,Jones GR

更新日期：2010-07-01 00:00:00

abstract：:We have studied 46 patients, 30 men and 16 women, with type 2 (non-insulin-dependent) diabetes in a follow-up period of 6-52 months (mean 30 months). The patients were consecutively entered in the study from the out-patient diabetic clinic. None had urinary tract infections nor proteinuria at entry. Investigations wer...

journal_title：Annals of clinical biochemistry

authors： Friis T,Pedersen LR

更新日期：1997-05-01 00:00:00

abstract：:Insulin resistance is a common condition, recognized to be a central feature of the metabolic syndrome, and strongly associated with an increased risk of cardiovascular disease and diabetes. The quantitative assessment of insulin sensitivity is not used for routine clinical purposes, but the emerging importance of ins...

journal_title：Annals of clinical biochemistry

authors： Borai A,Livingstone C,Ferns GA

更新日期：2007-07-01 00:00:00

abstract：:Background The clinical utility of serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma may be compromised by the presence of endogenous antithyroglobulin antibodies. To prevent interference by antithyroglobulin antibodies several groups have developed real-time PCR-based assays for q...

journal_title：Annals of clinical biochemistry

authors： Feddersen S,Bastholt L,Pedersen SM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Abundant evidence indicate the increased levels of oxidative stress in patients with autism. Advanced glycation end products and advanced lipoxidation end products and their precursors play a major role in increased oxidative stress in numerous metabolic and neurologic diseases. Carnosine is a natural dipept...

journal_title：Annals of clinical biochemistry

authors： Ghodsi R,Kheirouri S,Nosrati R

更新日期：2019-01-01 00:00:00

abstract：:A radioimmoassay for digoxin is described which uses commercially available reagents. Two assay procedures are used, one for batch assays, and another, which needs a 5 minute incubation only, for 'stat' assays. The methods are shown to be simple, rapid, precise and inexpensive and the batch procedure compared well wit...

journal_title：Annals of clinical biochemistry

authors： Moore RA,Turner M,Cousins J,Gales M

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The haptoglobin (Hp) 2-2 phenotype has been known to have less antioxidative activity than Hp 1-1 and Hp 2-1. However, few have reported the relationship between oxidative stress and Hp phenotypes by using oxidized LDL. The relationship between Hp phenotypes and oxidative stress was therefore investigated in...

journal_title：Annals of clinical biochemistry

authors： Lee YW,Min WK,Chun S,Lee W,Park H,Lee YK,Lee DH,Son JE

更新日期：2004-11-01 00:00:00

abstract：:Background Measured (MO) and calculated osmotic concentrations (CO) and the osmotic gap (OG) are commonly used in the investigation of electrolyte and volume disturbances as well as in cases of suspected volatile ingestion. Methods We compared 38 published formulae for CO with MO on a large data-set ( n = 9466) and ad...

journal_title：Annals of clinical biochemistry

authors： Wilgen U,Pretorius CJ,Ungerer JP

更新日期：2018-01-01 00:00:00

abstract：:Hereditary renal hypouricaemia (HRH) is a genetic disorder commonly associated with exercise-induced acute kidney injury (AKI). We report the case of a 19-year-old man who was admitted to hospital with exercise-induced AKI and who was subsequently shown to have HRH. We believe this to be the first description of a cas...

journal_title：Annals of clinical biochemistry

authors： Chakraborty S,Sural S

更新日期：2013-05-01 00:00:00

abstract：:A recently introduced turbidimetric immunoassay using shell/core particles for determination of myoglobin (Turbiquant Myoglobin, Behringwerke, Marburg, Germany) was evaluated on the Behring Turbitimer analyzer. Intra-assay CV varied between 1.0% and 3.2%; interassay CV was between 2.0% and 3.6%. Linear results were ob...

journal_title：Annals of clinical biochemistry

authors： Delanghe J,Chapelle JP,el Allaf M,De Buyzere M

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of ...

journal_title：Annals of clinical biochemistry

authors： Jacobs LH,van Borren M,Gemen E,van Eck M,van Son B,Glatz JF,Daniels M,Kusters R

更新日期：2015-09-01 00:00:00