Abstract：
BACKGROUND:Among patients with allergy to insect stings, double positivity in tests for IgE antibodies specific to honey bee and wasp venoms is a frequent diagnostic problem. True double sensitization and possible cross-reactivity of venom hyaluronidases and with carbohydrate determinants must be considered in such patients. We studied the frequency of sensitization to carbohydrate determinants and the role of these in double positivity in tests for specific IgE antibodies. MATERIALS AND METHODS:A group of 66 patients (41 men, 25 women; 16-66 years) with double positivity for wasp and bee venoms were tested in the FEIA inhibition test in order to distinguish true double sensitization from cross-reactivity. Patients were tested for the presence of IgE antibodies specific to oilseed rape (OSR) pollen and MUXF3 allergens, both of which are rich in cross-reacting carbohydrate epitopes. RESULTS:Inhibition tests revealed true double sensitization in 37 patients (56.1%) and cross-reactivity in 29. Among those showing cross-reactivity, five were sensitized to honey bee venom and 24 to wasp venom. The median value of IgE specific for OSR pollen in patients sensitized to honey bee venom was 4.350 IU/ml, in patients sensitized to wasp venom 0.61 IU/ml, and in patients with double sensitization 0.25 IU/ml (P = 0.028, Kruskal-Wallis test). Findings for IgE specific for MUXF3 were similar. Discordance between OSR pollen positivity and MUXF3 positivity was found in 11.1% of the patients. CONCLUSION:The values of IgE specific for OSR pollen and MUXF3 in patients with primary sensitization to either honey bee venom or wasp venom were significantly higher than in patients with double sensitization. These results confirm that IgE antibodies against carbohydrates epitopes are a frequent cause of double positivity in tests for anti-venom IgE antibodies.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Erzen R,Korosec P,Silar M,Music E,Kosnik Mdoi
10.1007/s00508-009-1171-1subject
Has Abstractpub_date
2009-01-01 00:00:00pages
349-52issue
9-10eissn
0043-5325issn
1613-7671journal_volume
121pub_type
杂志文章abstract：:The effects of etazolate and cartazolate, two pyrazolopyridine derivatives with anxiolytic actions, on the receptor binding of gamma-aminobutyric acid (GABA) was studied in vitro using membrane fractions prepared from rat brain. Both compounds increased the specific GABA receptor binding. This effect was markedly enha...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The recent emergence of a new coronavirus (severe acute respiratory syndrome coronavirus‑2, SARS-CoV-2) that is transmitted efficiently among humans and can result in serious disease and/or death has become a global threat to public health and economy. In this article, we describe some of the most important characteri...
journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Tobacco smoking is the major cause of lung disease. This study aimed to determine: 1) the prevalence of tobacco smoking among office-based physicians; 2) their readiness to inquire about their patients' smoking habits and, if need be, to motivate them to stop smoking; 3) whether non-smoking doctors advise their patien...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
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journal_title：Wiener klinische Wochenschrift
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doi：
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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更新日期：1998-01-01 00:00:00
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doi：
更新日期：1996-01-01 00:00:00
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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doi：
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abstract：OBJECTIVE AND METHODS:We performed a single center analysis of 60 adult patients (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HCT) at our institution. RESULTS:Allogeneic stem cell in patients w...
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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journal_title：Wiener klinische Wochenschrift
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