Influenza virus infection and the risk of serious bacterial infections in young febrile infants.

Abstract:

OBJECTIVE:We aimed to determine the risk of SBIs in febrile infants with influenza virus infections and compare this risk with that of febrile infants without influenza infections. PATIENTS AND METHODS:We conducted a multicenter, prospective, cross-sectional study during 3 consecutive influenza seasons. All febrile infants or=5 x 10(4) colony-forming units per mL or >or=10(4) colony-forming units per mL in association with a positive urinalysis. Bacteremia, bacterial meningitis, and bacterial enteritis were defined by growth of a known bacterial pathogen. SBI was defined as any of the 4 above-mentioned bacterial infections. RESULTS:During the 3-year study period, 1091 infants were enrolled. A total of 844 (77.4%) infants were tested for the influenza virus, of whom 123 (14.3%) tested positive. SBI status was determined in 809 (95.9%) of the 844 infants. Overall, 95 (11.7%) of the 809 infants tested for influenza virus had an SBI. Infants with influenza infections had a significantly lower prevalence of SBI (2.5%) and UTI (2.4%) when compared with infants who tested negative for the influenza virus. Although there were no cases of bacteremia, meningitis, or enteritis in the influenza-positive group, the differences between the 2 groups for these individual infections were not statistically significant. CONCLUSIONS:Febrile infants

journal_name

Pediatrics

journal_title

Pediatrics

authors

Krief WI,Levine DA,Platt SL,Macias CG,Dayan PS,Zorc JJ,Feffermann N,Kuppermann N,Multicenter RSV-SBI Study Group of the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics.

doi

10.1542/peds.2008-2915

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

30-9

issue

1

eissn

0031-4005

issn

1098-4275

pii

124/1/30

journal_volume

124

pub_type

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