Abstract：
:This study investigated the possible effects of a commonly used foliar herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on medulla spinalis of lebistes. Fish were exposed to 2,4-D (15, 30, 45 mg L(-1)), behavioral changes were monitored. Fish were fixed, histopathological examination was carried out on sections taken from the upper parts of the fish body. Histopathology showed increase in neuronal loss, swelling indicating formation of intracellular edema, vacuolization noticed as the formation of vacuoles within or adjacent to cells, deformation in the Nissl granules, pyknosis and gliosis in medulla spinalis. Behavioral changes were decreased general activity, grouping, shortness in breath, sudden rotations and jumping, loss of equilibrium and colour. In conclusion, this commercial formulation of 2,4-D is considerably neurotoxic to lebistes. Fish constitute the last link in the chain of the feeding cycle in aquatic eco-system, number of studies investigating acute and chronic neurotoxicity of various herbicides in fish should be increased.
journal_name
Chemospherejournal_title
Chemosphereauthors
Uyanikgil Y,Yalçinkaya M,Ateş U,Baka M,Karakişi Hdoi
10.1016/j.chemosphere.2009.06.018subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1386-91issue
10eissn
0045-6535issn
1879-1298pii
S0045-6535(09)00709-7journal_volume
76pub_type
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