Abstract:
:The function and survival of all organisms is dependent on the dynamic control of energy metabolism, when energy demand is matched to energy supply. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in all eukaryotes. In this review, we begin with the discovery of the AMPK family and discuss the recent structural studies that have revealed the molecular basis for AMP binding to the enzyme's gamma subunit. AMPK's regulation involves autoinhibitory features and phosphorylation of both the catalytic alpha subunit and the beta-targeting subunit. We review the role of AMPK at the cellular level through examination of its many substrates and discuss how it controls cellular energy balance. We look at how AMPK integrates stress responses such as exercise as well as nutrient and hormonal signals to control food intake, energy expenditure, and substrate utilization at the whole body level. Lastly, we review the possible role of AMPK in multiple common diseases and the role of the new age of drugs targeting AMPK signaling.
journal_name
Physiol Revjournal_title
Physiological reviewsauthors
Steinberg GR,Kemp BEdoi
10.1152/physrev.00011.2008subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1025-78issue
3eissn
0031-9333issn
1522-1210pii
89/3/1025journal_volume
89pub_type
杂志文章,评审abstract::There are two main classes of hormones in insects: 1) the true hormones produced by epithelial glands and belonging to the ecdysteroids or juvenile hormones and 2) the neuropeptide hormones produced by neurosecretory cells. Members of these classes regulate physiological, developmental, and behavioral events in insect...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
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pub_type: 传,历史文章,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
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journal_title:Physiological reviews
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pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
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更新日期:1998-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00