Abstract:
BACKGROUND:Thromboelastometry/elastography (ROTEM/TEG) showed promising results for diagnosis of sepsis-induced coagulopathy, but their association with the outcome is unclear. Our aim was to assess any difference in ROTEM/TEG measurements between septic survivors and non-survivors. METHODS:Pubmed, Web of Science, Embase and Cochrane Library databases were investigated. The research aimed to include any randomized or observational study: i) on septic adult patients admitted to Intensive Care Unit (ICU) or Emergency Department (ED); ii) including ROTEM/TEG; iii) assessing mortality. RESULTS:Seven prospective and four retrospective observational studies (952 patients) were included. According to the INTEM/kaolin-assay, clotting time (CT)/R (standardized mean difference(SMD) -0.29, 95% CI -0.49 to -0.09, p = 0.004) and clot formation time (CFT)/K (SMD -0.42, 95% CI -0.78 to -0.06, p = 0.02) were shorter in survivors. According to the EXTEM-assay, CT was shorter (MD -11.66 s, 95% CI -22.59 to -0.73, p = 0.04), while MCF was higher (MD 3.49 mm, 95% CI 0.43 to 6.55, p = 0.03) in survivors. A hypocoagulable profile was more frequent in non-survivors (OR 0.31, 95%CI 0.18 to 0.55, p < 0.0001). Overall, the risk of bias of the included studies was moderate and the quality of evidence low. CONCLUSIONS:Hypocoagulability and lower MCF in EXTEM may be associated with higher mortality in sepsis.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Boscolo A,Spiezia L,De Cassai A,Pasin L,Pesenti E,Zatta M,Zampirollo S,Andreatta G,Sella N,Pettenuzzo T,Rose K,Simioni P,Navalesi Pdoi
10.1016/j.jcrc.2020.09.034subject
Has Abstractpub_date
2021-02-01 00:00:00pages
5-13eissn
0883-9441issn
1557-8615pii
S0883-9441(20)30713-9journal_volume
61pub_type
杂志文章abstract::The science of safety is well established in such disciplines as the automotive and aviation industry. In this brief history of safety science as it pertains to patient care, we review remote and recent publications that have guided the maturation of this field that has particular relevance to the complex structure of...
journal_title:Journal of critical care
pub_type: 历史文章,杂志文章
doi:10.1016/j.jcrc.2005.02.003
更新日期:2005-03-01 00:00:00
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journal_title:Journal of critical care
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2004.09.003
更新日期:2004-12-01 00:00:00
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of critical care
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcrc.2013.11.021
更新日期:2014-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrc.2018.07.020
更新日期:2018-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 临床试验,杂志文章
doi:10.1016/j.jcrc.2004.07.009
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To explore perspectives of adult critical illness survivors and identify important aspects to care and recovery. MATERIALS AND METHODS:A descriptive, qualitative study of adult survivors of prolonged critical illness, six-months after Intensive Care Unit (ICU) discharge, using semi-structured interviews and th...
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2020.01.028
更新日期:2020-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2020.03.007
更新日期:2020-06-01 00:00:00
abstract::Noninvasive positive pressure ventilation has been demonstrated to be of benefit in preventing endotracheal intubation and reducing mortality in specific patients in the setting of acute exacerbations of chronic obstructive pulmonary disease. The successful application of noninvasive positive pressure ventilation depe...
journal_title:Journal of critical care
pub_type: 指南,杂志文章,实务指引
doi:10.1016/j.jcrc.2004.04.006
更新日期:2004-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/s0883-9441(98)90022-3
更新日期:1998-03-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2018.01.018
更新日期:2018-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcrc.2017.08.014
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.jcrc.2017.08.010
更新日期:2017-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2007.09.006
更新日期:2008-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2018.09.031
更新日期:2018-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.02.021
更新日期:2017-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2019.02.018
更新日期:2019-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2012.12.013
更新日期:2013-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2009.01.011
更新日期:2009-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2013.11.012
更新日期:2014-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2008.08.012
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To investigate the predictive value of left ventricular-arterial coupling (VAC) for clinical prognosis of elderly patients with septic shock. MATERIALS AND METHODS:This was a single-center prospective cohort study of 63 elderly patients with septic shock treated between August 2014 and January 2016 at the 30-b...
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.08.017
更新日期:2017-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2009.11.002
更新日期:2010-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.10.038
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The ICU is a scarce resource within a high-stress, high-stakes, time-sensitive environment where critically ill patients with life-threatening conditions receive expensive life-sustaining care under the guidance of expert qualified personnel. The implications of decisions such as suitability for admission in...
journal_title:Journal of critical care
pub_type:
doi:10.1016/j.jcrc.2018.11.027
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the incidence of pressure ulcers (PUs) in ventilated patients in all intensive care units (ICUs) in Granada (Spain) and identify risk factors for their development. MATERIALS AND METHODS:A prospective cohort study in 9 medical-surgical ICUs was conducted. Two hundred nine...
journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2009.09.002
更新日期:2010-09-01 00:00:00