Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides.

abstract：:Aging is amenable to intervention and prevention by mild stress-induced hormesis. Previously, we have reported that repeated mild heat stress has antiaging and other beneficial effects on growth and a range of cellular and biochemical characteristics of normal human skin fibroblasts and keratinocytes undergoing aging ...

journal_title：Annals of the New York Academy of Sciences

authors： Rattan SI,Sejersen H,Fernandes RA,Luo W

更新日期：2007-11-01 00:00:00

abstract：:The characteristics of about 2,000 Japanese sarcoidosis cases collected by the Japan Sarcoidosis Committee during the 10-yr period, 1963-1972, were chronological increase with decreasing infectious diseases (represented by tuberculosis), north-to-south decline in sarcoidosis incidence in accordance with the Oxford Atl...

journal_title：Annals of the New York Academy of Sciences

authors： Hosoda Y,Hiraga Y,Odaka M,Yangawa H,Ito Y,Shiegematsu I,Chiba Y

更新日期：1976-01-01 00:00:00

abstract：:Molecular dynamics (MD) are performed in all-atom simulations of two polymer species based on polythiophene. In one case the amphiphilic polymer forms a monolayer interface between a vacuum and an aqueous layer containing ions. The electroactive nature of the polymer is invoked by conferring a negative charge on it to...

journal_title：Annals of the New York Academy of Sciences

authors： Morton-Blake DA,Leith D

更新日期：2009-04-01 00:00:00

abstract：:We are used to thinking of mathematics as a symbolic activity. Here I argue that it may also be seen as a performative one. Making an analogy with music, I draw attention to the ways in which mathematics may not only be written down but also played out. ...

journal_title：Annals of the New York Academy of Sciences

authors： Wertheim M

更新日期：2019-12-01 00:00:00

abstract：:The results reviewed here demonstrate that vestibulospinal and vestibulo-ocular interneurons in the chicken embryo are organized into coherent clusters, each of which occupies a unique spatial domain and has a characteristic axon trajectory. Moreover, the vestibulo-ocular clusters have specific termination patterns in...

journal_title：Annals of the New York Academy of Sciences

authors： Glover JC

更新日期：1996-06-19 00:00:00

abstract：:Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

journal_title：Annals of the New York Academy of Sciences

authors： Slifka MK,Ahmed R

更新日期：1996-10-25 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:The prevalence of taste loss over a discrete area of the tongue or palate is unknown; however, we have identified discrete losses in three etiological groups: head trauma, upper respiratory infection, and bulimia. We have now identified discrete losses in elderly subjects. To summarize, elderly subjects show elevated ...

journal_title：Annals of the New York Academy of Sciences

authors： Bartoshuk LM

更新日期：1989-01-01 00:00:00

abstract：:Cardiac afferent neurons are activated in the setting of myocardial ischemia and mediate the sensation of angina. However, the precise stimuli and receptive molecules responsible are not completely understood. To further investigate the molecular components involved, cardiac afferents were isolated in dissociated cult...

journal_title：Annals of the New York Academy of Sciences

authors： Benson CJ,Sutherland SP

更新日期：2001-06-01 00:00:00

abstract：:1. There are several endogenous ligands that bind to I-receptors of both the I1 and I2 subclass. These include: (a) classic CDS, a partially purified entity isolated by the criteria that it displaces binding ligands to alpha 2- and I-receptors; (b) immunoreactive (ir)-CDS, a moiety that binds to antibodies raised agai...

journal_title：Annals of the New York Academy of Sciences

authors： Reis DJ,Li G,Regunathan S

更新日期：1995-07-12 00:00:00

abstract：:Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

journal_title：Annals of the New York Academy of Sciences

authors： Dhabhar FS

更新日期：2003-05-01 00:00:00

abstract：:Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main area...

journal_title：Annals of the New York Academy of Sciences

authors： Caplat P,Coutts S,Buckley YM

更新日期：2012-02-01 00:00:00

abstract：:Deprivation of sympathetic neurons of their physiological neurotrophic factor, nerve growth factor (NGF), leads to degeneration of soma and neurites, followed by loss of viability. The progression of degeneration and death are dependent upon macromolecular synthesis indicating an active participation of neuronal metab...

journal_title：Annals of the New York Academy of Sciences

authors： Deckwerth TL,Johnson EM Jr

更新日期：1993-05-28 00:00:00

abstract：:In this experiment, we investigated the influence of the photoperiod upon androgen receptor (AR) distribution and steroid concentrations in ovaries of 21-day-old bank vole females. Sections (6 mum) were assayed immunohistochemically. ARs were localized in the nuclei of granulosa cells. The strongest immunoreaction was...

journal_title：Annals of the New York Academy of Sciences

authors： Galas J,Slomczynska M,Kwasnik A

更新日期：2005-04-01 00:00:00

abstract：:The Knockout Mouse Project (KOMP) Repository archives and distributes vectors, embryonic stem cell clones, frozen germplasm, and live mutant mice for 8,500 knockout genes. Here, we describe the creation and functions of the KOMP Repository. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lloyd KC

更新日期：2011-12-01 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:Obesity is a phenotype resulting from a series of causative factors with a variable risk of complications. Etiologic diversity requires personalized prevention and treatment. Imaging procedures offer the potential to investigate the interplay between organs and pathways underlying energy intake and consumption in an i...

journal_title：Annals of the New York Academy of Sciences

authors： Iozzo P

更新日期：2015-09-01 00:00:00

abstract：:Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothel...

journal_title：Annals of the New York Academy of Sciences

authors： Shelton EL,Bader DM

更新日期：2012-10-01 00:00:00

abstract：:Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous high-amplitude rhythmical electroencephalography (EEG) spike activity an...

journal_title：Annals of the New York Academy of Sciences

authors： Dhir A,Bruun DA,Guignet M,Tsai YH,González E,Calsbeek J,Vu J,Saito N,Tancredi DJ,Harvey DJ,Lein PJ,Rogawski MA

更新日期：2020-11-01 00:00:00

abstract：:Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...

journal_title：Annals of the New York Academy of Sciences

authors： Manheimer-Lory A,Irigoyen M,Gaynor B,Monhian R,Splaver A,Diamond B

更新日期：1995-09-29 00:00:00

abstract：:Higher levels of body fat are associated with increased risk for development of numerous adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing adipose tissue mass. Resveratrol decrea...

journal_title：Annals of the New York Academy of Sciences

authors： Baile CA,Yang JY,Rayalam S,Hartzell DL,Lai CY,Andersen C,Della-Fera MA

更新日期：2011-01-01 00:00:00

abstract：:Mytilus edulis, a marine bivalve mollusc, contains hemocytes that share certain properties with cells of the human monocyte-macrophage lineage. Because of this and previously reported similar responses to opioids between Mytilus hemocytes and human granulocytes, we determined whether Mytilus might also possess monokin...

journal_title：Annals of the New York Academy of Sciences

authors： Hughes TK Jr,Smith EM,Leung MK,Stefano GB

更新日期：1992-04-15 00:00:00

abstract：:Gene therapy for beta-globinopathies, particularly beta-thalassemia and sickle cell anemia, hold much promise for the future, as a one time cure for these common and debilitating disorders. Correction of the beta-globinopathies using lentivirus vectors (LV) carrying the beta- or gamma-globin genes and elements of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Perumbeti A,Malik P

更新日期：2010-08-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with HLA B27. But the association is not absolute. Hence association with other HLA class I antigens and class II alleles was studied in a southern Indian population. Sixty-five patients with primary AS were typed serologically for HLA class I ...

journal_title：Annals of the New York Academy of Sciences

authors： Madhavan R,Parthiban M,Rajendran CP,Chandrasekaran AN,Zake L,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:Recent studies suggest that the symptoms associated with endometriosis are the result of local peritoneal inflammation. Increased concentrations of activated pelvic macrophages and lymphocytes and the elevated levels of specific cytokines and growth factors reviewed above support this hypothesis. The precise roles of ...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor RN,Ryan IP,Moore ES,Hornung D,Shifren JL,Tseng JF

更新日期：1997-09-26 00:00:00

abstract：:A 1.2 kb polymorphic fragment from the Gardel isolate of Ehrlichia (formerly Cowdria) ruminantium was used to isolate a 15kb clone from the E. ruminantium Welgevonden LambdaGEM-11 library. This clone, WL2EL1, was subcloned and sequenced. Eight open reading frames (ORFs) were identified. The ORF in WL2EL1 which contain...

journal_title：Annals of the New York Academy of Sciences

authors： Louw E,Brayton KA,Collins NE,Pretorius A,Van Strijp F,Allsopp BA

更新日期：2002-10-01 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:Thymic epithelial and nurse cells from different species express a repertoire of neuroendocrine polypeptide precursors. This repertoire exerts a dual role in T-lymphocyte selection according to their status either as cryptocrine signals or as neuroendocrine self-antigens of the peptide sequences that are processed fro...

journal_title：Annals of the New York Academy of Sciences

authors： Geenen V,Martens H,Vandersmissen E,Achour I,Kecha O,Franchimont D

更新日期：1998-05-01 00:00:00

abstract：:Auditory brainstem potentials were recorded from various scalp and nasopharyngeal sites referenced both to a noncephalic site and to certain scalp locations in normal humans. The distribution of amplitudes and latencies of the components were defined. There were significant amplitude, polarity, and latency asymmetries...

journal_title：Annals of the New York Academy of Sciences

authors： Starr A,Squires K

更新日期：1982-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and peptide histidine-isoleucine (PHI) are members of a superfamily of structurally related peptides widely distributed in the body and displaying pleiotropic biological activities. All these peptides are known to act via ...

journal_title：Annals of the New York Academy of Sciences

authors： Dejda A,Jozwiak-Bebenista M,Nowak JZ

更新日期：2006-07-01 00:00:00