Abstract:
Purpose of review:The purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options. Recent findings:This review highlights recent advancements in our understanding of known causes of myositis, including newer drugs that may cause myositis such as checkpoint inhibitors and viruses such as influenza, HIV, and SARS-CoV2. We also discuss treatment for malignancy-associated myositis and overlap myositis, thought to be a separate entity from other rheumatologic diseases. Summary:Infections, drugs, rheumatologic diseases, and malignancies are important causes of myositis and are important to diagnose as they may have specific therapies beyond immunomodulatory therapy.
journal_name
Curr Treat Options Neuroljournal_title
Current treatment options in neurologyauthors
Berth SH,Lloyd TEdoi
10.1007/s11940-020-00646-0subject
Has Abstractpub_date
2020-01-01 00:00:00pages
38issue
11eissn
1092-8480issn
1534-3138pii
646journal_volume
22pub_type
杂志文章,评审abstract:OPINION STATEMENT:Infantile spasms (IS) represent a major therapeutic challenge, as cessation of spasms and normalization of the electroencephalogram (elimination of hypsarrhythmia) are mandatory to prevent cognitive deterioration in previously healthy infants, or to preserve neurocognitive function among those neurolo...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-012-0181-x
更新日期:2012-08-01 00:00:00
abstract::Spontaneous intracerebral hemorrhage (ICH) is a devastating neurological event with a 30-day mortality of approximately 40%. Recent research provides new insights into the pathophysiology of ICH-associated edema, with potential molecular and cellular targets for future therapy. Neuroimaging techniques such as gradient...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-006-0005-y
更新日期:2006-03-01 00:00:00
abstract::Progressive supranuclear palsy (PSP) is an atypical parkinsonian disorder that, in spite of its growing recognition, is still underdiagnosed. For management, prognosis, and research, an accurate and early diagnosis is essential. PSP is a relentlessly progressive neurodegenerative disorder, clinically characterized by ...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-006-0012-z
更新日期:2006-05-01 00:00:00
abstract::Patients with functional or nonorganic visual disturbances are often seen in general ophthalmology practice and then referred to neurology and/or neuro-ophthalmology. The diagnosis of functional vision loss requires comprehensive examinations and diagnostic testing to eliminate possible organic entities. Inconsistenci...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-996-0023-9
更新日期:2006-01-01 00:00:00
abstract:OPINION STATEMENT:Therapeutic hypothermia has proven neuroprotective effects in global cerebral ischemia. Indications for hypothermia induction include cardiac arrest and neonatal asphyxia. The two general methods of induced hypothermia are either surface cooling or endovascular cooling. Hypothermia should be induced a...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-012-0201-x
更新日期:2012-12-01 00:00:00
abstract::Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. Ischemic stroke is more common than cerebral venous thrombosis and hemorrhagic stroke in children. Several medical disorders have been associated with stroke in children, and a thorough evaluation of underlying causes is n...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-005-0047-6
更新日期:2005-11-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that usually results in death secondary to respiratory failure. The psychological reaction to the diagnosis of ALS in patient and caregiver has received increasing attention. Reports are highly variable as to the severity of depressive symptoms ...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-006-0030-x
更新日期:2006-09-01 00:00:00
abstract::The initial treatment for trigeminal neuralgia is medical. Carbamazepine is the drug of choice. If the patient proves to be intolerant of carbamazepine, a number of second-line drugs are available, though data on their relative efficacy are nonexistent. Phenytoin, baclofen, clonazepam, and sodium valproate are all wor...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-996-0009-7
更新日期:1999-11-01 00:00:00
abstract::Acute viral meningitis is the most common infection of the central nervous system. Most cases occur in children and young adults and are due to enteroviruses. Although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of bette...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-008-0018-9
更新日期:2008-05-01 00:00:00
abstract::The mainstay of treatment of amyotrophic lateral sclerosis (ALS) is management of symptoms. Health care providers involved in the care of ALS patients should be armed with the most current knowledge about symptomatic management of these patients so that an aggressive approach to controlling symptoms can be undertaken ...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-008-0009-x
更新日期:2008-03-01 00:00:00
abstract::Arteriovenous malformations (AVM) are a leading cause of intracerebral hemorrhage, especially among the young. Because they pose a lifelong risk of serious bleeding, definitive treatment to obliterate the AVM should be pursued in the majority of patients. Microsurgical resection of a small AVM located in the superfici...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-002-0011-7
更新日期:2002-11-01 00:00:00
abstract:OPINION STATEMENT:Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a common condition characterized by an irresistible urge to move the legs, concomitant with an unpleasant sensation in the lower limbs, which is typically relieved by movement. Symptoms occur predominantly at rest and prevail in the afternoon or...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-015-0390-1
更新日期:2016-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Children surviving the pediatric intensive care unit (PICU) with neurologic illness or injury have long-term morbidities in physical, cognitive, emotional, and social functioning termed postintensive care syndrome (PICS). In this article, we review acute and longitudinal management strategies availabl...
journal_title:Current treatment options in neurology
pub_type: 杂志文章,评审
doi:10.1007/s11940-019-0586-x
更新日期:2019-09-27 00:00:00
abstract::The treatment of progressive myoclonus epilepsy (PME) remains a major therapeutic challenge in neurology. Generalized convulsive seizures are often well controlled through classic antiepileptic drugs (AEDs) like valproate and clonazepam, whereas myoclonus, the main symptom that is affecting patients most in their dail...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-002-0001-9
更新日期:2002-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify...
journal_title:Current treatment options in neurology
pub_type: 杂志文章,评审
doi:10.1007/s11940-019-0543-8
更新日期:2019-01-19 00:00:00
abstract::Cervicocranial arterial dissection (CCAD) occurs when there is a tear in the intimal layer of the carotid or vertebral arteries with subsequent extravasation of blood into the subintimal layers. The dissection may be extradural, intradural, or extend over both segments. The contents of the subintimal layers are highly...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-007-0031-4
更新日期:2007-01-01 00:00:00
abstract:OPINION STATEMENT:Kleine-Levin Syndrome [KLS] is often under-recognized and also misdiagnosed. When suspicion for KLS is raised, a thorough clinical evaluation should be performed, including detailed history from family members and a neurologic and psychiatric examination. Additional studies may include PSG, EEG, neuro...
journal_title:Current treatment options in neurology
pub_type: 杂志文章,评审
doi:10.1007/s11940-016-0409-2
更新日期:2016-06-01 00:00:00
abstract::Neuromyelitis optica (Devic's syndrome) is an uncommon, idiopathic, demyelinating syndrome of the central nervous system that preferentially affects the optic nerves and spinal cord. It frequently is misdiagnosed as severe multiple sclerosis, but usually is readily distinguished from multiple sclerosis in fully develo...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-005-0010-6
更新日期:2005-05-01 00:00:00
abstract::Although estimates vary, the nervous system appears to be involved in 10% to 15% of patients infected with Borrelia burgdorferi. The resulting disorders, known collectively as neuroborreliosis or nervous system Lyme disease, generally respond well to antimicrobial therapy. Definitive treatment of nervous system infect...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-007-0035-0
更新日期:2007-03-01 00:00:00
abstract:Purpose of Review:Giant cell arteritis (GCA), a medium and large vessel vasculitis occurring in the aged, remains a formidable disease, capable of taking both vision and life, through a multitude of vascular complications. Our understanding of the spectrum of its manifestations has grown over the years, to include limb...
journal_title:Current treatment options in neurology
pub_type: 杂志文章,评审
doi:10.1007/s11940-020-00660-2
更新日期:2021-01-01 00:00:00
abstract::The epidemiologic link between increased low-density-lipoprotein (LDL) cholesterol and ischemic stroke is controversial. However, recent trials make it clear that LDL reduction by statin agents in high-risk patients reduces the risk of ischemic stroke. The risk of first stroke is reduced within 1 to 2 years of statin ...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-006-0039-1
更新日期:2006-11-01 00:00:00
abstract::Neuralgic amyotrophy has a broad variety of clinical manifestations. Although it was initially thought to be a plexopathy, its diverse presentation can include isolated sensory nerves or even cranial nerves. Although neuralgic amyotrophy is usually a benign condition with a good recovery, pain can be a disabling featu...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-009-0011-y
更新日期:2009-03-01 00:00:00
abstract::Neuromyelitis optica (NMO, Devic's syndrome) is characterized by concurrence of optic neuritis and transverse myelitis, typically associated with a lesion in the spinal cord extending over three or more vertebral segments. It is an inflammatory, demyelinating central nervous system disorder, and although it is most co...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-008-0007-z
更新日期:2008-01-01 00:00:00
abstract::Allodynia is a normal part of the untreated migraine attack in most people with episodic migraine and is prevalent in chronic migraine. The extent to which allo-dynia contributes to the pain and disability of migraine attacks is unclear, as is its clinical importance. The presence of allodynia correlates with the seve...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-009-0001-0
更新日期:2009-01-01 00:00:00
abstract::After a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the bias towards continuing therapy indefinitely can be substantial. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs, bu...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-010-0083-8
更新日期:2010-09-01 00:00:00
abstract::Apathy is a common problem observed in numerous neurologic, psychiatric, and other medical conditions. It is independent from other symptoms and has been associated with a variety of negative outcomes. However, little empirical research has been conducted on potential psychologic or pharmacologic treatments for apathy...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::Lysosomal storage disorders (LSDs), over 40 different diseases, are now considered treatable disorders. Only a few short years ago, Lysosomal storage disorders were seen as interesting neurodegenerative disorders without any potential for treatment. Effective treatment strategies such as bone marrow transplantation (B...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-001-0006-9
更新日期:2001-05-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Psychosis is broadly defined as a disengagement from reality. It describes syndromes that impair both thought content and thought process. Psychosis negatively impacts an individual's quality of life, in addition to the families caring for them. Psychosis with different types of hallucinations and...
journal_title:Current treatment options in neurology
pub_type: 杂志文章,评审
doi:10.1007/s11940-019-0545-6
更新日期:2019-01-23 00:00:00
abstract::Vision disturbances following traumatic brain injury (TBI) include anomalies of accommodation, version, vergence (nonstrabismic, as well as strabismic), photosensitivity, visual field integrity, and ocular health. Traumatic brain injury patients with complex diplopia patterns, noncomitant strabismic anomalies, and adv...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-002-0027-z
更新日期:2002-07-01 00:00:00
abstract:OPINION STATEMENT:Parkinson's disease (PD) has been increasingly recognized as having a multitude of nonmotor symptoms including psychosis, cognitive impairment and dementia, mood disturbances, fatigue, apathy, and sleep disorders. Psychosis and dementia, in particular, greatly affect quality of life for both patients ...
journal_title:Current treatment options in neurology
pub_type: 杂志文章
doi:10.1007/s11940-013-0281-2
更新日期:2014-03-01 00:00:00