Stopping antiepileptic drugs: when and why?

abstract：:Dystonia is a neurologic disorder that can occur at any age and often results in significant disability. The therapeutic application of botulinum toxin has revolutionized the treatment of this disorder, particularly for the adult-onset focal forms such as cervical dystonia and blepharospasm. The two available commerci...

journal_title：Current treatment options in neurology

authors： Cardona-Garcia OD,Higgins DS,Molho ES

更新日期：2007-05-01 00:00:00

abstract：:Arteriovenous malformations (AVM) are a leading cause of intracerebral hemorrhage, especially among the young. Because they pose a lifelong risk of serious bleeding, definitive treatment to obliterate the AVM should be pursued in the majority of patients. Microsurgical resection of a small AVM located in the superfici...

journal_title：Current treatment options in neurology

authors： Graham GD

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable neurological disorder of the elderly population that is characterized by abnormal ventricular enlargement due to cerebrospinal fluid (CSF) accumulation and gait disturbance, cognitive impairment, or urinary incontinence. The obj...

journal_title：Current treatment options in neurology

authors： Isaacs AM,Williams MA,Hamilton MG

更新日期：2019-12-03 00:00:00

abstract：:The primary goal of treatment in nonepileptic seizures (NES) is to improve the patient's quality of life by terminating seizure production or reducing seizure frequency. Initial treatment consists of explaining the diagnosis and its psychological nature to patients without judging them or giving the NES excessive atte...

journal_title：Current treatment options in neurology

authors： Bowman ES

更新日期：2000-11-01 00:00:00

abstract：:Vagus nerve stimulation is a unique therapy for epileptic seizures. Two randomized controlled trials in patients with medically refractory partial seizures have demonstrated efficacy, leading to US Food and Drug Administration approval of vagus nerve stimulation therapy in 1997. Extensive safety testing has not reveal...

journal_title：Current treatment options in neurology

authors： Salinsky MC

更新日期：2003-03-01 00:00:00

abstract：:Allodynia is a normal part of the untreated migraine attack in most people with episodic migraine and is prevalent in chronic migraine. The extent to which allo-dynia contributes to the pain and disability of migraine attacks is unclear, as is its clinical importance. The presence of allodynia correlates with the seve...

journal_title：Current treatment options in neurology

authors： Young WB

更新日期：2009-01-01 00:00:00

abstract：:The treatments for obstructive sleep apnea (OSA) described in this paper represent the latest information and data. Nasal continuous positive airway pressure, initially described in 1981, remains the cornerstone of therapy. Advances in mask interfaces, the use of humidification, the downloading of usage information, t...

journal_title：Current treatment options in neurology

authors： Collop NA

更新日期：2009-09-01 00:00:00

abstract：OPINION STATEMENT:Parkinson's disease (PD) has been increasingly recognized as having a multitude of nonmotor symptoms including psychosis, cognitive impairment and dementia, mood disturbances, fatigue, apathy, and sleep disorders. Psychosis and dementia, in particular, greatly affect quality of life for both patients ...

journal_title：Current treatment options in neurology

authors： Goldman JG,Holden S

更新日期：2014-03-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disorder characterized clinically by proximal weakness and bulbar symptoms and pathologically by damage to the post-synaptic membrane at the neuromuscular junction. Ocular myasthenia gravis (ocular MG) is a form of myasthenia gravis whereby the patients' weakness is limited to t...

journal_title：Current treatment options in neurology

authors： Porter NC,Salter BC

更新日期：2005-01-01 00:00:00

abstract：OPINION STATEMENT:Myotonic dystrophy (DM1) is the most common form of adult muscular dystrophy. It is a multisystem disorder with a complex pathophysiology. Although inheritance is autosomal dominant, disease variability is attributed to anticipation, a maternal expansion bias, variable penetrance, somatic mosaicism, a...

journal_title：Current treatment options in neurology

authors： Smith CA,Gutmann L

更新日期：2016-12-01 00:00:00

abstract：:A sleep history should be taken routinely in patients with epilepsy. Treatment of sleep disorders and improvement in sleep hygiene may improve seizure control, daytime cognitive functioning, and quality of life. Patients with recurrent sleepiness interfering with daily activities or an Epworth Sleepiness Scale score m...

journal_title：Current treatment options in neurology

authors： Herman ST

更新日期：2006-07-01 00:00:00

abstract：:Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. Ischemic stroke is more common than cerebral venous thrombosis and hemorrhagic stroke in children. Several medical disorders have been associated with stroke in children, and a thorough evaluation of underlying causes is n...

journal_title：Current treatment options in neurology

authors： Lynch JK,Pavlakis S,Deveber G

更新日期：2005-11-01 00:00:00

abstract：:There is no standard therapy for acute disseminated encephalomyelitis (ADEM), and treatments are based on the analogy of the pathogenesis of ADEM with that of multiple sclerosis (MS), namely an inflammatory perivenular demyelination. High-dose intravenous corticosteroids, such as methylprednisolone, at a dosage standa...

journal_title：Current treatment options in neurology

authors： Tselis A

更新日期：2001-11-01 00:00:00

abstract：:The treatment of progressive myoclonus epilepsy (PME) remains a major therapeutic challenge in neurology. Generalized convulsive seizures are often well controlled through classic antiepileptic drugs (AEDs) like valproate and clonazepam, whereas myoclonus, the main symptom that is affecting patients most in their dail...

journal_title：Current treatment options in neurology

authors： Uthman BM,Reichl A

更新日期：2002-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that usually results in death secondary to respiratory failure. The psychological reaction to the diagnosis of ALS in patient and caregiver has received increasing attention. Reports are highly variable as to the severity of depressive symptoms ...

journal_title：Current treatment options in neurology

authors： Stromberg SF,Weiss DB

更新日期：2006-09-01 00:00:00

abstract：:The epidemiologic link between increased low-density-lipoprotein (LDL) cholesterol and ischemic stroke is controversial. However, recent trials make it clear that LDL reduction by statin agents in high-risk patients reduces the risk of ischemic stroke. The risk of first stroke is reduced within 1 to 2 years of statin ...

journal_title：Current treatment options in neurology

authors： Bernstein RA

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Children surviving the pediatric intensive care unit (PICU) with neurologic illness or injury have long-term morbidities in physical, cognitive, emotional, and social functioning termed postintensive care syndrome (PICS). In this article, we review acute and longitudinal management strategies availabl...

journal_title：Current treatment options in neurology

authors： Williams CN,Hartman ME,Guilliams KP,Guerriero RM,Piantino JA,Bosworth CC,Leonard SS,Bradbury K,Wagner A,Hall TA

更新日期：2019-09-27 00:00:00

abstract：:The challenge for the neurologist in the treatment of Lyme neuroborreliosis is not in the treatment per se, but in the diagnosis. Neurological manifestations of Lyme disease can present in many forms, and diagnostic techniques which detect the spirochete directly; the culture or polymerase chain reaction of the spiroc...

journal_title：Current treatment options in neurology

authors： Pachner AR

更新日期：2005-03-01 00:00:00

abstract：OPINION STATEMENT:Therapeutic hypothermia has proven neuroprotective effects in global cerebral ischemia. Indications for hypothermia induction include cardiac arrest and neonatal asphyxia. The two general methods of induced hypothermia are either surface cooling or endovascular cooling. Hypothermia should be induced a...

journal_title：Current treatment options in neurology

authors： Song SS,Lyden PD

更新日期：2012-12-01 00:00:00

abstract：:Medical management, the mainstay of treatment for partial epilepsy, involves choosing from an array of antiseizure drugs, most of which have comparable efficacy against partial-onset seizures. Effective treatment strategies involve matching the characteristics of drug and patient to control seizures without adverse ef...

journal_title：Current treatment options in neurology

authors： Liu L,Henry JC

更新日期：2009-07-01 00:00:00

abstract：:Acute viral meningitis is the most common infection of the central nervous system. Most cases occur in children and young adults and are due to enteroviruses. Although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of bette...

journal_title：Current treatment options in neurology

authors： Davis LE

更新日期：2008-05-01 00:00:00

abstract：:Given our current knowledge, there is a need for the early institution of immunomodulatory therapy, especially for patients with poor prognostic factors (motor and cerebellar symptoms, frequent disease exacerbations, and a high level of activity on magnetic resonance imaging ). Patients who progress despite immunomodu...

journal_title：Current treatment options in neurology

authors： Bielekova B,Martin R

更新日期：1999-07-01 00:00:00

abstract：OPINION STATEMENT:CLIPPERS for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, is a steroid-sensitive and steroid-dependent brainstem inflammatory disease of unknown origin. Since its first description in 2010, about 60 cases have been reported throughout the world. The me...

journal_title：Current treatment options in neurology

authors： Taieb G,Allou T,Labauge P

更新日期：2017-05-01 00:00:00

abstract：:Subdural empyema represents loculated infection between the outermost layer of the meninges, the dura, and the arachnoid. The empyema may develop intracranially or in the spinal canal. Intracranial subdural empyema is most frequently a complication of sinusitis or, less frequently, otitis or neurosurgical procedures. ...

journal_title：Current treatment options in neurology

authors： Greenlee JE

更新日期：2003-01-01 00:00:00

abstract：OPINION STATEMENT:Paroxysmal dyskinesia represents a group of uncommon movement disorders that are characterized by episodes of abnormal movements arising from a baseline of normal or nearly normal movement. Recent advances in the genetics of these disorders have helped provide some unification of classification scheme...

journal_title：Current treatment options in neurology

authors： Mink JW

更新日期：2015-06-01 00:00:00

abstract：:Herpes simplex virus (HSV) infections are ubiquitous. Children are infected with HSV resulting in totally asymptomatic acquisition to life-threatening disease. Therapy of HSV diseases of children can be considered according to severity and time of acquisition. Neonatal herpes simplex virus infections take one of three...

journal_title：Current treatment options in neurology

authors： Whitley RJ

更新日期：2002-05-01 00:00:00

abstract：OPINION STATEMENT:Neurofibromatosis type 1 (NF1) is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. This condition is caused by inherited or de novo mutations of the NF1 gene at the 17q11.2 chromosomal region, a gene t...

journal_title：Current treatment options in neurology

authors： Sabatini C,Milani D,Menni F,Tadini G,Esposito S

更新日期：2015-06-01 00:00:00

abstract：Purpose of Review:Giant cell arteritis (GCA), a medium and large vessel vasculitis occurring in the aged, remains a formidable disease, capable of taking both vision and life, through a multitude of vascular complications. Our understanding of the spectrum of its manifestations has grown over the years, to include limb...

journal_title：Current treatment options in neurology

authors： Dinkin M,Johnson E

更新日期：2021-01-01 00:00:00

abstract：:Migraine is a common, chronic neurologic disorder that affects approximately 12% of the adult population in Western countries. Once migraine is diagnosed, illness severity must be assessed. Clinicians and patients should then work together to develop a treatment plan based on patient needs and preferences. The goals o...

journal_title：Current treatment options in neurology

authors： Bigal ME,Lipton RB

更新日期：2003-11-01 00:00:00

abstract：:The treatment of complex partial seizure (CPS) begins with accurate diagnosis. Episodes of staring and unresponsiveness due to nonepileptic causes must be ruled out. Absence seizures (typical and atypical petit mal) must be considered because the treatment strategy and prognosis for these seizures are very different f...

journal_title：Current treatment options in neurology

authors： Buchhalter JR

更新日期：1999-09-01 00:00:00