Abstract：
OPINION STATEMENT:Paroxysmal dyskinesia represents a group of uncommon movement disorders that are characterized by episodes of abnormal movements arising from a baseline of normal or nearly normal movement. Recent advances in the genetics of these disorders have helped provide some unification of classification schemes and better understanding. However, the approach to treatment continues to be based on the phenotype more than the genotype. The treatment approach is primarily based on the factors that precipitate the episodes of abnormal movements. For paroxysmal kinesigenic dyskinesia (PKD) in which the spells are triggered by sudden movement, treatment with anticonvulsants that target voltage-sensitive sodium channels (e.g., carbamazepine or phenytoin) is highly effective. For paroxysmal nonkinesigenic dyskinesia (PNKD), treatment with benzodiazepines is effective in many patients. PNKD episodes are often precipitated by caffeine, ethanol, or sleep deprivation, and lifestyle modifications are often helpful. Paroxysmal exertion-induced dyskinesia (PED) is less likely to respond to medications, but the ketogenic diet or modified Atkins diet may provide benefit. As more knowledge is gained about the underlying biology of these disorders, additional treatments may emerge.
journal_name
Curr Treat Options Neuroljournal_title
Current treatment options in neurologyauthors
Mink JWdoi
10.1007/s11940-015-0350-9subject
Has Abstractpub_date
2015-06-01 00:00:00pages
350issue
6eissn
1092-8480issn
1534-3138journal_volume
17pub_type
杂志文章abstract：:Myasthenia gravis (MG) is an autoimmune disorder characterized clinically by proximal weakness and bulbar symptoms and pathologically by damage to the post-synaptic membrane at the neuromuscular junction. Ocular myasthenia gravis (ocular MG) is a form of myasthenia gravis whereby the patients' weakness is limited to t...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-005-0009-z
更新日期：2005-01-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Psychosis is broadly defined as a disengagement from reality. It describes syndromes that impair both thought content and thought process. Psychosis negatively impacts an individual's quality of life, in addition to the families caring for them. Psychosis with different types of hallucinations and...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0545-6
更新日期：2019-01-23 00:00:00
abstract：OPINION STATEMENT:The purpose of this review is to provide an overview of visual snow (VS) and provide information regarding current treatment options for VS. Visual snow (VS) is a rare disorder manifesting with a persistent visual phenomenon of seeing numerous tiny snow-like dots throughout the visual field, and it ca...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-017-0448-3
更新日期：2017-03-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize the current evidence regarding the impact of the exposure to anesthetic and sedative agents on neurodevelopment during the period of rapid brain growth in the first 3 years of life. Though much of the definitive data demonstrating anesthesia-induced neurotoxi...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-018-0536-z
更新日期：2018-10-13 00:00:00
abstract：PURPOSE OF REVIEW:Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable neurological disorder of the elderly population that is characterized by abnormal ventricular enlargement due to cerebrospinal fluid (CSF) accumulation and gait disturbance, cognitive impairment, or urinary incontinence. The obj...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0604-z
更新日期：2019-12-03 00:00:00
abstract：OPINION STATEMENT:Cerebral vasospasm (cVSP) consists of the vasoconstriction of large and small intracranial vessels which can lead to cerebral hypoperfusion, and in extreme cases, delayed ischemic deficits with stroke. While most commonly observed after aneurysmal subarachnoid hemorrhage (aSAH), cVSP can also occur af...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-013-0278-x
更新日期：2014-01-01 00:00:00
abstract：OPINION STATEMENT:The treatment of anaplastic glioma (AG) varies depending on histopathology of the tumor, molecular markers, and individual patient characteristics. Maximal surgical resection is desirable for all types of AG if technically feasible, with an acceptable level of risk, and with the goal of preserving neu...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-012-0177-6
更新日期：2012-08-01 00:00:00
abstract：:Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. Ischemic stroke is more common than cerebral venous thrombosis and hemorrhagic stroke in children. Several medical disorders have been associated with stroke in children, and a thorough evaluation of underlying causes is n...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-005-0047-6
更新日期：2005-11-01 00:00:00
abstract：OPINION STATEMENT:The problem of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) management remains unsolved. Despite a myriad of therapeutic trials, no convincingly e...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-012-0211-8
更新日期：2013-02-01 00:00:00
abstract：:Neuromyelitis optica (Devic's syndrome) is an uncommon, idiopathic, demyelinating syndrome of the central nervous system that preferentially affects the optic nerves and spinal cord. It frequently is misdiagnosed as severe multiple sclerosis, but usually is readily distinguished from multiple sclerosis in fully develo...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-005-0010-6
更新日期：2005-05-01 00:00:00
abstract：:After a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the bias towards continuing therapy indefinitely can be substantial. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs, bu...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-010-0083-8
更新日期：2010-09-01 00:00:00
abstract：:The mainstay of treatment of amyotrophic lateral sclerosis (ALS) is management of symptoms. Health care providers involved in the care of ALS patients should be armed with the most current knowledge about symptomatic management of these patients so that an aggressive approach to controlling symptoms can be undertaken ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-008-0009-x
更新日期：2008-03-01 00:00:00
abstract：OPINION STATEMENT:Autoimmune neuromuscular disorders in childhood include Guillain-Barré syndrome and its variants, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), juvenile myasthenia gravis (JMG), and juvenile dermatomyositis (JDM), along with other disorders rarely seen in childhood. In general, the...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-011-0146-5
更新日期：2011-12-01 00:00:00
abstract：OPINION STATEMENT:Triptans, selective serotonin receptor agonists, were developed almost 20 years ago and represented a major breakthrough in the treatment of acute migraine attacks. Since then, the triptans have become first-line agents for most patients with migraine, both with and without aura, unless contraindicate...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-010-0082-9
更新日期：2010-09-01 00:00:00
abstract：:Autistic spectrum disorders (ASD) are an often-disabling continuum of disorders affecting two to four in 1000 children. These disorders have a core set of defining features including impaired verbal and nonverbal communication, impaired social interaction, and restricted or repetitive patterns of behavior. The cause o...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-996-0030-x
更新日期：2004-09-01 00:00:00
abstract：OPINION STATEMENT:Solid organ transplantation is frequently complicated by a spectrum of seizure types, including single partial-onset or generalized tonic-clonic seizures, acute repetitive seizures or status epilepticus, and sometimes the evolution of symptomatic epilepsy. There is currently no specific evidence invol...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-012-0180-y
更新日期：2012-08-01 00:00:00
abstract：Purpose of review:The purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options. Recent findings:This review highlights recent advancements in our understanding of known causes of myositis, including newer drugs that may cause myositis s...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-020-00646-0
更新日期：2020-01-01 00:00:00
abstract：OPINION STATEMENT:Treatment of myoclonus requires an understanding of the physiopathology of the condition. The first step in treatment is to determine if there is an epileptic component to the myoclonus and treat accordingly. Secondly, a review of medications (e.g., opiates) and comorbidities (e.g., hepatic or renal f...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-016-0404-7
更新日期：2016-05-01 00:00:00
abstract：:Acute viral meningitis is the most common infection of the central nervous system. Most cases occur in children and young adults and are due to enteroviruses. Although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of bette...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-008-0018-9
更新日期：2008-05-01 00:00:00
abstract：:Drug-induced parkinsonism (DIP) is condition that mimics Parkinson's disease. Characterized mainly by rigidity and bradykinesia, it has less prominent tremor and gait instability. DIP is generally caused by lipophilic drugs that "block" dopamine D2 receptors in the brain, although presynaptic dopamine depletion, false...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-009-0019-3
更新日期：2009-05-01 00:00:00
abstract：OPINION STATEMENT:The management of herpes zoster (HZ) usually involves a multidisciplinary approach aiming to reduce complications and morbidity. Patients with herpes zoster ophthalmicus (HZO) are referred to ophthalmologists for prevention or treatment of its potential complications. Without prompt detection and trea...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-010-0098-1
更新日期：2011-02-01 00:00:00
abstract：OPINION STATEMENT:Kleine-Levin Syndrome [KLS] is often under-recognized and also misdiagnosed. When suspicion for KLS is raised, a thorough clinical evaluation should be performed, including detailed history from family members and a neurologic and psychiatric examination. Additional studies may include PSG, EEG, neuro...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-016-0409-2
更新日期：2016-06-01 00:00:00
abstract：OPINION STATEMENT:The recognition of the diagnosis of migraine in the pediatric population is increasing. Early and aggressive treatment of migraine in children and adolescents with the use of over-the-counter medications has proven effective. In addition, the off-label use of many migraine-specific medications is ofte...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-010-0069-6
更新日期：2010-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0543-8
更新日期：2019-01-19 00:00:00
abstract：OPINION STATEMENT:Restless legs syndrome (RLS) is a common, sensorimotor, circadian sleep disorder characterized by the urge to move the legs, particularly at nighttime. It is important to differentiate primary and secondary RLS from other conditions, which can mimic the symptoms of RLS, in particular neuropathy and cr...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-013-0241-x
更新日期：2013-08-01 00:00:00
abstract：:When the diagnosis of antiphospholipid antibody syndrome (aPS) is being considered in persons who have experienced an ischemic stroke or a transient ischemic attack, it is important to gauge how well the history and laboratory data fit with this diagnosis as opposed to other causes of infarct. The fewer the number of ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-000-0043-9
更新日期：2000-09-01 00:00:00
abstract：:The primary goal of treatment in nonepileptic seizures (NES) is to improve the patient's quality of life by terminating seizure production or reducing seizure frequency. Initial treatment consists of explaining the diagnosis and its psychological nature to patients without judging them or giving the NES excessive atte...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-000-0034-x
更新日期：2000-11-01 00:00:00
abstract：OPINION STATEMENT:A patient presenting with suspected primary central nervous system (CNS) vasculitis is often difficult to manage. Once the diagnosis is suspected, the clinical course may already be severe and warrant timely aggressive treatment with potentially toxic drugs. Definitive diagnosis is often delayed, requ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-013-0227-8
更新日期：2013-06-01 00:00:00
abstract：:Acute hearing loss (AHL) is a medical urgency. The management of patients presenting with sudden deafness involves detecting the causal mechanism and administering emergency therapeutic drugs to restore hearing by minimizing the period of cellular ischemia to the inner ear. Acute management of AHL consists of administ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-004-0039-y
更新日期：2004-01-01 00:00:00
abstract：:Transplantation of bone marrow or peripheral blood stem cells is increasingly being used to treat a variety of oncologic disorders. These procedures are associated with a large spectrum of neurologic complications that significantly contribute to patient morbidity and mortality. These complications may arise at any ti...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-007-0016-3
更新日期：2007-07-01 00:00:00
