Botulinum toxin in the management of dystonia.

Abstract:

:Dystonia is a neurologic disorder that can occur at any age and often results in significant disability. The therapeutic application of botulinum toxin has revolutionized the treatment of this disorder, particularly for the adult-onset focal forms such as cervical dystonia and blepharospasm. The two available commercial preparations, botulinum toxin types A and B, have been shown to be equally efficacious in cervical dystonia and are both reasonable first-line choices for treating other forms of focal dystonia. Preliminary studies have suggested that differences in tolerability and immunogenicity may exist between the two preparations, but this has not been adequately evaluated. Because of high cost, complicated administration, potentially serious side effects, and the risk of developing immunoresistance, this treatment should be administered only by a physician with sufficient background in the diagnosis and treatment of dystonia, to ensure optimal outcomes.

authors

Cardona-Garcia OD,Higgins DS,Molho ES

doi

10.1007/BF02938412

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

224-33

issue

3

eissn

1092-8480

issn

1534-3138

journal_volume

9

pub_type

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