In ACS, prasugrel reduces 30-day MACE and mortality vs. ticagrelor or clopidogrel; no differences for major bleeding.

abstract：BACKGROUND:Health care-associated infections from invasive medical devices in the intensive care unit (ICU) are a major threat to patient safety. Most published studies of ICU-acquired infections have come from industrialized western countries. In a Centers for Disease Control and Prevention (CDC) National Nosocomial I...

journal_title：Annals of internal medicine

authors： Rosenthal VD,Maki DG,Salomao R,Moreno CA,Mehta Y,Higuera F,Cuellar LE,Arikan OA,Abouqal R,Leblebicioglu H,International Nosocomial Infection Control Consortium.

更新日期：2006-10-17 00:00:00

abstract：:This paper is part 1 of a 2-part series on interpretation of 12-lead resting electrocardiograms (ECGs). Part 1 is a position paper that presents recommendations for initial competency, competency assessment, and maintenance of competency on ECG interpretation, as well as recommendations for the role of computer-assist...

journal_title：Annals of internal medicine

authors： Salerno SM,Alguire PC,Waxman HS,American College of Physicians.

更新日期：2003-05-06 00:00:00

abstract：OBJECTIVE:To prospectively study the clinical features, pathophysiology, treatment and prognosis of Wegener granulomatosis. DESIGN:Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 ye...

journal_title：Annals of internal medicine

authors： Hoffman GS,Kerr GS,Leavitt RY,Hallahan CW,Lebovics RS,Travis WD,Rottem M,Fauci AS

更新日期：1992-03-15 00:00:00

abstract：BACKGROUND:Plasma levels of leptin, the recently discovered satiety hormone, are associated with adiposity in humans. OBJECTIVE:To determine whether genetic factors or body fat distribution affect the association between leptin levels and obesity. PARTICIPANTS:23 healthy identical twin pairs (9 male pairs and 14 fema...

journal_title：Annals of internal medicine

authors： Rönnemaa T,Karonen SL,Rissanen A,Koskenvuo M,Koivisto VA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Screening women for Chlamydia trachomatis in family planning clinics is associated with a reduced incidence of chlamydial sequelae. However, the question of whom to screen to maintain efficient use of resources remains controversial. OBJECTIVE:To assess the cost-effectiveness of chlamydial screening done ac...

journal_title：Annals of internal medicine

authors： Howell MR,Quinn TC,Gaydos CA

更新日期：1998-02-15 00:00:00

abstract：:The diagnosis of gout depends on showing urate crystals in synovial effusions or, with less certainty, recognizing a characteristic clinical presentation. The management of gout has four phases: control of inflammation, diagnostic evaluation, education of the patient, and treatment for the hyperuricemia. Sound logical...

journal_title：Annals of internal medicine

authors： Simkin PA

更新日期：1979-05-01 00:00:00

abstract：:Advances have recently been made in understanding the pharmacokinetics of theophylline. To correlate the new knowledge of theophylline pharmacokinetics with the drug's current status in therapy, we have critically reviewed the relevant investigations of the last 5 years. We consider data on its presumed mechanisms of ...

journal_title：Annals of internal medicine

authors： Bukowskyj M,Nakatsu K,Munt PW

更新日期：1984-07-01 00:00:00

abstract：:Medical devices have become an integral part of hospital-based care but also predispose patients to more than 850 000 device-related infections annually. Devices predispose to infection by damaging or invading epithelial and mucosal barriers to infection, by supporting growth of microorganisms and thus serving as rese...

journal_title：Annals of internal medicine

authors： Stamm WE

更新日期：1978-11-01 00:00:00

abstract：:Although thyroid nodules are common, few are malignant and require surgical treatment. A systematic approach to their evaluation is important to avoid unnecessary surgery. Fine-needle aspiration biopsy has resulted in substantial improvements in diagnostic accuracy, cost reductions, and higher malignancy yield at time...

journal_title：Annals of internal medicine

authors： Castro MR,Gharib H

更新日期：2005-06-07 00:00:00

abstract：:Two hundred forty previously healthy military personnel with nonstreptococcal upper respiratory infections were prospectively studied to define the incidence and clinicopathologic characteristics of possible virus-associated glomerulonephritis. Nine patients without preceding streptococcal infection had erythrocyte ca...

journal_title：Annals of internal medicine

authors： Smith MC,Cooke JH,Zimmerman DM,Bird JJ,Feaster BL,Morrison RE,Reimann BE

更新日期：1979-11-01 00:00:00

abstract：OBJECTIVE:To determine the effect of treating Helicobacter pylori infection on the recurrence of gastric and duodenal ulcer disease. DESIGN:Follow-up of up to 2 years in patients with healed ulcers who had participated in randomized, controlled trials. SETTING:A Veterans Affairs hospital. PARTICIPANTS:A total of 109...

journal_title：Annals of internal medicine

authors： Graham DY,Lew GM,Klein PD,Evans DG,Evans DJ Jr,Saeed ZA,Malaty HM

更新日期：1992-05-01 00:00:00

abstract：:A recent, widely publicized meta-analysis of 42 clinical trials concluded that rosiglitazone was associated with an approximately 43% increased risk for myocardial infarction and an approximately 64% increased risk for cardiovascular death. The sensitivity of these conclusions to several methodological choices was not...

journal_title：Annals of internal medicine

authors： Diamond GA,Bax L,Kaul S

更新日期：2007-10-16 00:00:00

abstract：:The earthquake that struck Haiti in January 2010 caused an estimated 230,000 deaths and injured approximately 250,000 people. The Israel Defense Forces Medical Corps Field Hospital was fully operational on site only 89 hours after the earthquake struck and was capable of providing sophisticated medical care. During th...

journal_title：Annals of internal medicine

authors： Kreiss Y,Merin O,Peleg K,Levy G,Vinker S,Sagi R,Abargel A,Bartal C,Lin G,Bar A,Bar-On E,Schwaber MJ,Ash N

更新日期：2010-07-06 00:00:00

abstract：:Medical school graduates are avoiding primary care. The very aspects that once attracted students have been subverted. The breadth of practice that was once appealing has become the breadth of heavy-handed scrutiny, as politicians and business leaders have demanded quality--simplistically defined as dogmatic adherence...

journal_title：Annals of internal medicine

authors： Norenberg DD

更新日期：2009-05-19 00:00:00

abstract：:Young adults with cystic fibrosis have lower blood pressures than control subjects of similar age and sex. The low blood pressure may be related to the excessive loss of salt in the sweat of these patients. A beneficial effect of the cystic fibrosis gene may be protection against developing hypertension in both the ho...

journal_title：Annals of internal medicine

authors： Lieberman J,Rodbard S

更新日期：1975-06-01 00:00:00

abstract：:Myocardial infarction was diagnosed in 431 (30%) of 1460 patients with acute chest pain who had serial enzyme testing after admission to intensive or intermediate care units at three teaching and three community hospitals. The diagnosis was made within 12 hours of admission in 331 (77%) patients and within 24 hours in...

journal_title：Annals of internal medicine

authors： Lee TH,Rouan GW,Weisberg MC,Brand DA,Cook EF,Acampora D,Goldman L

更新日期：1987-02-01 00:00:00

abstract：:Eighty-six patients who required heparin therapy were randomly assigned to receive bovine or porcine heparin. Abnormal concentrations of alanine transaminase and aspartate transaminase developed during treatment in 59.3% and 26.7% of patients, respectively. Patient characteristics that significantly influenced the dev...

journal_title：Annals of internal medicine

authors： Dukes GE Jr,Sanders SW,Russo J Jr,Swenson E,Burnakis TG,Saffle JR,Warden GD

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Progress of diabetes care is a subject of public health concern. OBJECTIVE:To assess changes in quality of diabetes care in the United States by using standardized measures. DESIGN:National population-based, serial cross-sectional surveys. SETTING:National Health and Nutrition Examination Survey (1988-199...

journal_title：Annals of internal medicine

authors： Saaddine JB,Cadwell B,Gregg EW,Engelgau MM,Vinicor F,Imperatore G,Narayan KM

更新日期：2006-04-04 00:00:00

abstract：:Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. All patients had previous mucocutaneous reactions to chrysotherapy. Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances...

journal_title：Annals of internal medicine

authors： Chalmers A,Thompson D,Stein HE,Reid G,Patterson AC

更新日期：1982-11-01 00:00:00

abstract：:During the past decade, medical therapy for AIDS has become more effective but also prohibitively expensive. A medical tragedy has been transformed into a financial crisis, and society has responded by establishing special programs and sources of funding for AIDS. These maneuvers parallel earlier approaches to HIV tes...

journal_title：Annals of internal medicine

authors： Casarett DJ,Lantos JD

更新日期：1998-05-01 00:00:00

abstract：Background:The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and ...

journal_title：Annals of internal medicine

authors： Berkhemer OA,Borst J,Kappelhof M,Yoo AJ,van den Berg LA,Fransen PSS,Beumer D,Schonewille WJ,Nederkoorn PJ,Wermer MJH,Marquering HA,Lingsma HF,Roos YBWEM,van Oostenbrugge RJ,Dippel DWJ,van Zwam WH,Majoie CBLM,Emmer BJ,

更新日期：2017-06-20 00:00:00

abstract：:We surveyed the faculty, fellows, and residents of a department of medicine to determine the relative importance of each of eight personal characteristics evaluated during the interview of house staff candidates. A booklet containing all possible pairings of the eight characteristics was distributed to 219 participant...

journal_title：Annals of internal medicine

authors： Greganti MA,McGaghie WC,Finn WF

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension. OBJECTIVE:To determine effects on blood pressure of reduced sodium intake and the ...

journal_title：Annals of internal medicine

authors： Vollmer WM,Sacks FM,Ard J,Appel LJ,Bray GA,Simons-Morton DG,Conlin PR,Svetkey LP,Erlinger TP,Moore TJ,Karanja N,DASH-Sodium Trial Collaborative Research Group.

更新日期：2001-12-18 00:00:00

abstract：BACKGROUND:Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes. OBJECTIVE:To evaluate whether total and high-molecular-weight adiponectin and resistin are associated with future risk for type 2 diabetes, independent of obesity and other kn...

journal_title：Annals of internal medicine

authors： Heidemann C,Sun Q,van Dam RM,Meigs JB,Zhang C,Tworoger SS,Mantzoros CS,Hu FB

更新日期：2008-09-02 00:00:00

abstract：STUDY OBJECTIVE:To assess the long-term benefit and side effects of danazol therapy, and to delineate factors influencing the responses in patients with autoimmune thrombocytopenia. DESIGN:Before and after trial. SETTING:Referral-based hematology clinics and the University of Miami teaching hospitals. PATIENTS:Data ...

journal_title：Annals of internal medicine

authors： Ahn YS,Rocha R,Mylvaganam R,Garcia R,Duncan R,Harrington WJ

更新日期：1989-11-01 00:00:00

abstract：:Poststreptococcal acute glomerulonephritis is prototypic of the immunologic glomerulonephritides. It most commonly follows streptococcal infection of the pharynx or skin. The diagnosis is usually not difficult when a nephritic clinical presentation (with such manifestations as hematuria, edema, and hypertension) is as...

journal_title：Annals of internal medicine

authors： Nissenson AR,Baraff LJ,Fine RN,Knutson DW

更新日期：1979-07-01 00:00:00

abstract：:Effective health care is a core determinant of successful aging, and medications are one of the most important therapeutic tools of health care providers. Most older adults use at least one prescription drug. Costs for these drugs are a substantial out-of-pocket expense for Medicare beneficiaries, and low-income older...

journal_title：Annals of internal medicine

authors： Murray MD,Callahan CM

更新日期：2003-09-02 00:00:00

abstract：BACKGROUND:In previous open-label noncomparative clinical trials, both fluconazole and itraconazole were effective therapy for progressive forms of coccidioidomycosis. OBJECTIVE:To determine whether fluconazole or itraconazole is superior for treatment of nonmeningeal progressive coccidioidal infections. DESIGN:Rando...

journal_title：Annals of internal medicine

authors： Galgiani JN,Catanzaro A,Cloud GA,Johnson RH,Williams PL,Mirels LF,Nassar F,Lutz JE,Stevens DA,Sharkey PK,Singh VR,Larsen RA,Delgado KL,Flanigan C,Rinaldi MG

更新日期：2000-11-07 00:00:00

abstract：:Since 1970, forty-two patients with pulmonary hypertension due to chronic, thromboembolic obstruction of the major pulmonary arteries have had pulmonary thromboendarterectomy at the University of California, San Diego, and the San Diego Veterans Medical Centers. Duration of symptoms before admission averaged 4.4 years...

journal_title：Annals of internal medicine

authors： Moser KM,Daily PO,Peterson K,Dembitsky W,Vapnek JM,Shure D,Utley J,Archibald C

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:A common criticism of randomized, controlled trials (RCTs) is that the enrollment process may be highly selective and those who enroll may not represent persons in the general population. The recruitment process reported in published RCTs has not been systematically evaluated. OBJECTIVE:To determine whether...

journal_title：Annals of internal medicine

authors： Gross CP,Mallory R,Heiat A,Krumholz HM

更新日期：2002-07-02 00:00:00