Abstract:
:The present study quantitatively assessed volumes of the amygdala and its subnuclei in autopsied cases of advanced Alzheimer's disease (AD) for comparison with age-matched controls. Amygdalar nuclei showed significant atrophy in AD with the exception of the paralaminar portion of the basal nucleus. The magnocellular regions of the amygdala showed proportionately greater size reductions as a fraction of total amygdala volume than did other areas. Computerized reconstruction of the amygdala provided three-dimensional views of a variety of structural alterations accompanying the volumetric declines with AD. The apparent selective vulnerability of the magnocellular amygdalar areas coincides with the loss of large nerve cells in AD.
journal_name
Neurologyjournal_title
Neurologyauthors
Scott SA,DeKosky ST,Scheff SWdoi
10.1212/wnl.41.3.351subject
Has Abstractpub_date
1991-03-01 00:00:00pages
351-6issue
3eissn
0028-3878issn
1526-632Xjournal_volume
41pub_type
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