Abstract:
OBJECTIVES:Radiomic involves testing the associations of a large number of quantitative imaging features with clinical characteristics. Our aim was to extract a radiomic signature from axial T2-weighted (T2-W) magnetic resonance imaging (MRI) of the whole prostate able to predict oncological and radiological scores in prostate cancer (PCa). METHODS:This study included 65 patients with localized PCa treated with radiotherapy (RT) between 2014 and 2018. For each patient, the T2-W MRI images were normalized with the histogram intensity scale standardization method. Features were extracted with the IBEX software. The association of each radiomic feature with risk class, T-stage, Gleason score (GS), extracapsular extension (ECE) score, and Prostate Imaging Reporting and Data System (PI-RADS v2) score was assessed by univariate and multivariate analysis. RESULTS:Forty-nine out of 65 patients were eligible. Among the 1702 features extracted, 3 to 6 features with the highest predictive power were selected for each outcome. This analysis showed that texture features were the most predictive for GS, PI-RADS v2 score, and risk class; intensity features were highly associated with T-stage, ECE score, and risk class, with areas under the receiver operating characteristic curve (ROC AUC) ranging from 0.74 to 0.94. CONCLUSIONS:MRI-based radiomics is a promising tool for prediction of PCa characteristics. Although a significant association was found between the selected features and all the mentioned clinical/radiological scores, further validations on larger cohorts are needed before these findings can be applied in the clinical practice. KEY POINTS:• A radiomic model was used to classify PCa aggressiveness. • Radiomic analysis was performed on T2-W magnetic resonance images of the whole prostate gland. • The most predictive features belong to the texture (57%) and intensity (43%) domains.
journal_name
Eur Radioljournal_title
European radiologyauthors
Gugliandolo SG,Pepa M,Isaksson LJ,Marvaso G,Raimondi S,Botta F,Gandini S,Ciardo D,Volpe S,Riva G,Rojas DP,Zerini D,Pricolo P,Alessi S,Petralia G,Summers PE,Mistretta FA,Luzzago S,Cattani F,De Cobelli O,Cassano E,doi
10.1007/s00330-020-07105-zsubject
Has Abstractpub_date
2021-02-01 00:00:00pages
716-728issue
2eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07105-zjournal_volume
31pub_type
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