The effect of noise on CaMKII activation in a dendritic spine during LTP induction.

abstract：:Electrophysiological analysis has revealed much about the broad coding and neural ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats and about how these dynamics relate to behavior. With regard to mice, however, data concerning cortical taste coding have largely been restricted ...

journal_title：Journal of neurophysiology

authors： Levitan D,Lin JY,Wachutka J,Mukherjee N,Nelson SB,Katz DB

更新日期：2019-10-01 00:00:00

abstract：:The discovery that neuroligin is a key protein involved in synapse formation offers the unprecedented opportunity to induce functional synapses between neurons and heterologous cells. We took this opportunity recording for the first-time synaptic currents in human embryonic kidney 293 (HEK293) cells transfected with n...

journal_title：Journal of neurophysiology

authors： Fu Z,Washbourne P,Ortinski P,Vicini S

更新日期：2003-12-01 00:00:00

abstract：:1. We reexamined the important areas of conflict in (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced potentiation of the field excitatory postsynaptic potential (EPSP) and, for the first time, investigated the role of mGluRs in EPSP-spike (E-S) coupling. 2. (1S,3R)-ACPD (10 microM) bath applied...

journal_title：Journal of neurophysiology

authors： Breakwell NA,Rowan MJ,Anwyl R

更新日期：1996-11-01 00:00:00

abstract：:1. Neocortical brain slices were prepared from rats (35-50 days of age) and maintained in vitro. Intracellular recordings were obtained from neurons in cortical layers II/III. The effect of bath application of cyclothiazide (CYZ), a potent blocker of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor...

journal_title：Journal of neurophysiology

authors： Pelletier MR,Hablitz JJ

更新日期：1994-08-01 00:00:00

abstract：:The responses of low-frequency, primary-like neurons of the ventral cochlear nucleus were measured as a function of signal-to-noise ratio for gated tonal signals and noise maskers that were varied in bandwidth and duration. For a given signal-to-noise ratio, each of the maskers is known to produce the same amount of m...

journal_title：Journal of neurophysiology

authors： Langford TL

更新日期：1983-12-01 00:00:00

abstract：:The purpose of this study was to compare the discharge characteristics of motor units recruited during an isometric contraction that was sustained with the elbow flexor muscles by older adults at target forces that were less than the recruitment threshold force of each isolated motor unit. The discharge times of 27 si...

journal_title：Journal of neurophysiology

authors： Pascoe MA,Holmes MR,Enoka RM

更新日期：2011-02-01 00:00:00

abstract：:1. Over two thirds of caudal medullary raphespinal neurons respond to electrical stimulation of the vestibular nerve, and it has been suggested that these neurons may participate in the generation of vestibulospinal and vestibulosympathetic reflexes. The objective of the present study was to determine which vestibular...

journal_title：Journal of neurophysiology

authors： Yates BJ,Goto T,Kerman I,Bolton PS

更新日期：1993-09-01 00:00:00

abstract：:Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

journal_title：Journal of neurophysiology

authors： Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

更新日期：2012-06-01 00:00:00

abstract：:The high variability of cortical sensory responses is often assumed to impose a major constraint on efficient computation. In the auditory cortex, however, response variability can be very low. We have used in vivo whole cell patch-clamp methods to study the trial-to-trial variability of the subthreshold fluctuations ...

journal_title：Journal of neurophysiology

authors： Deweese MR,Zador AM

更新日期：2004-09-01 00:00:00

abstract：:Unitary discharge patterns (peristimulus time histograms or PSTH) and synaptic events were studies with intracellular recording techniques in 164 cat cochlear nucleus cells to steady-frequency tone bursts 250 ms in duration. There were four response types defined on the basis of the shape of the discharge patterns to ...

journal_title：Journal of neurophysiology

authors： Britt R,Starr A

更新日期：1976-01-01 00:00:00

abstract：:The voltage-gated K(+) channel Kv1.3 has been reported to regulate transmitter release in select central and peripheral neurons. In this study, we evaluated its role at the synapse between visceral sensory afferents and secondary neurons in the nucleus of the solitary tract (NTS). We identified mRNA and protein for Kv...

journal_title：Journal of neurophysiology

authors： Ramirez-Navarro A,Glazebrook PA,Kane-Sutton M,Padro C,Kline DD,Kunze DL

更新日期：2011-06-01 00:00:00

abstract：:1. The proton-gated current was investigated in whole-cell configuration of the neurons isolated from bullfrog heart parasympathetic ganglia with the use of the "concentration-clamp" technique, which combines intracellular perfusion and extremely rapid exchange of external solution within 1-2 ms, under a single-electr...

journal_title：Journal of neurophysiology

authors： Kim DK,Tateishi N,Akaike N

更新日期：1990-05-01 00:00:00

abstract：:1. The preceding study described a corrective response in cats when one hind leg steps into a hole. In this investigation we examine the extent to which this behavior is organized at the spinal level by comparing the responses elicited in intact and chronic spinal cats. 2. Adult cats were trained to step bipedally wit...

journal_title：Journal of neurophysiology

authors： Hiebert GW,Gorassini MA,Jiang W,Prochazka A,Pearson KG

更新日期：1994-02-01 00:00:00

abstract：:1. In four human subjects, we measured the latency of saccadic eye movements made to a second, eccentric target after an initial, foveated target was extinguished. In separate interleaved trails, the targets were either both stationary ("fixation") or both moving with the same velocity ("pursuit"). For both fixation a...

journal_title：Journal of neurophysiology

authors： Krauzlis RJ,Miles FA

更新日期：1996-12-01 00:00:00

abstract：:Transcranial DC stimulation (tDCS) induces stimulation polarity-dependent neuroplastic excitability shifts in the human brain. Because it accomplishes long-lasting effects and its application is simple, it is used increasingly. However, one drawback is its low focality, caused by 1) the large stimulation electrode and...

journal_title：Journal of neurophysiology

authors： Nitsche MA,Doemkes S,Karaköse T,Antal A,Liebetanz D,Lang N,Tergau F,Paulus W

更新日期：2007-04-01 00:00:00

abstract：:Tinnitus is a phantom auditory perception without an external sound source and is one of the most common public health concerns that impair the quality of life of many individuals. However, its neural mechanisms remain unclear. We herein examined population-level frequency tuning in the auditory cortex of unilateral t...

journal_title：Journal of neurophysiology

authors： Sekiya K,Takahashi M,Murakami S,Kakigi R,Okamoto H

更新日期：2017-03-01 00:00:00

abstract：:In quadrupeds, the dorsal-side-up body orientation during standing is maintained due to a postural system that is driven by feedback signals coming mainly from limb mechanoreceptors. In caudally decerebrated (postmammillary) rabbits, the efficacy of this system is considerably reduced. In this paper, we report that th...

journal_title：Journal of neurophysiology

authors： Zelenin PV,Hsu LJ,Orlovsky GN,Deliagina TG

更新日期：2012-06-01 00:00:00

abstract：:ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative disease characterized by a progressive and selective loss of motoneurons. Transgenic mice overexpressing a mutated human gene (G93A) coding for the enzyme SOD1 (Cu/Zn superoxide dismutase) develop a motoneuron disease resembling ALS in ...

journal_title：Journal of neurophysiology

authors： Kuo JJ,Schonewille M,Siddique T,Schults AN,Fu R,Bär PR,Anelli R,Heckman CJ,Kroese AB

更新日期：2004-01-01 00:00:00

abstract：:To trigger action potentials in neurons, most investigators use electrical or chemical stimulation. Here we describe an optical stimulation method based on semi-synthetic light-activated ion channels. These SPARK (synthetic photoisomerizable azobenzene-regulated K(+)) channels consist of a synthetic azobenzene-contain...

journal_title：Journal of neurophysiology

authors： Chambers JJ,Banghart MR,Trauner D,Kramer RH

更新日期：2006-11-01 00:00:00

abstract：:There are three common ways by which to successfully terminate gait: decreased acceleration of whole-body center of mass (COM) through a flexor synergy in the trail leg, increased deceleration of whole-body COM through an extensor synergy in the front limb, and an energy/momentum transfer to dissipate any remaining mo...

journal_title：Journal of neurophysiology

authors： Oates AR,Patla AE,Frank JS,Greig MA

更新日期：2005-01-01 00:00:00

abstract：:Interjoint reflex function of the insect leg contributes to postural control at rest or to movement control during locomotor movements. In the stick insect (Carausius morosus), we investigated the role that sensory signals from the femoral chordotonal organ (fCO), the transducer of the femur-tibia (FT) joint, play in ...

journal_title：Journal of neurophysiology

authors： Hess D,Büschges A

更新日期：1999-04-01 00:00:00

abstract：:1. A variety of pharmacological tests indicate that the neuromuscular junction between the salivary burster neuron (SB) and the salivary duct muscle (SD) in the terrestrial mollusk Limax maximus is cholinergic. These include the effects of curare, atropine, and hexamethonium. 2. Exogenously applied choline can act bot...

journal_title：Journal of neurophysiology

authors： Barry SR,Gelperin A

更新日期：1982-08-01 00:00:00

abstract：:Motoneurons receive synaptic inputs from tens of thousands of connections that cause membrane potential to fluctuate continuously (synaptic noise), which introduces variability in discharge times of action potentials. We hypothesized that the influence of synaptic noise on force steadiness during voluntary contraction...

journal_title：Journal of neurophysiology

authors： Dideriksen JL,Negro F,Enoka RM,Farina D

更新日期：2012-06-01 00:00:00

abstract：:1. Eye movements were recorded before and after bilateral occipital lobectomy in six rhesus monkeys trained to fixate and to follow small targets. Striate cortex was completely removed in two animals; small islands islands remained in the others. In all animals portions of extrastriate cortex were also removed but the...

journal_title：Journal of neurophysiology

authors： Zee DS,Tusa RJ,Herdman SJ,Butler PH,Gücer G

更新日期：1987-10-01 00:00:00

abstract：:The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cells in seizures. Despite the presence of robust recurrent mossy f...

journal_title：Journal of neurophysiology

authors： Hardison JL,Okazaki MM,Nadler JV

更新日期：2000-11-01 00:00:00

abstract：:Overestimation of roll tilt in hypergravity ("G-excess" illusion) has been demonstrated, but corresponding sustained hypogravic conditions are impossible to create in ground laboratories. In this article we describe the first systematic experimental evidence that in a hypogravity analog, humans underestimate roll tilt...

journal_title：Journal of neurophysiology

authors： Galvan-Garza RC,Clark TK,Sherwood D,Diaz-Artiles A,Rosenberg M,Natapoff A,Karmali F,Oman CM,Young LR

更新日期：2018-12-01 00:00:00

abstract：:The macaque middle temporal area (MT) is exquisitely sensitive to visual motion and there is a large amount of evidence that neural activity in MT is tightly correlated with the perception of motion. The mechanisms by which MT neurons achieve their directional selectivity, however, have received considerably less atte...

journal_title：Journal of neurophysiology

authors： Krekelberg B,Albright TD

更新日期：2005-05-01 00:00:00

abstract：:One of the fundamental principles of neuroscience is that direct electrical interactions between neurons are not possible without specialized electrical contacts, gap junctions, because the transmembrane resistance of neurons is typically much higher than the resistance of the adjacent extracellular space. However it ...

journal_title：Journal of neurophysiology

authors： Dmitriev AV,Mangel SC

更新日期：2006-03-01 00:00:00

abstract：:The process of sensorimotor adaptation is considered to be driven by errors. While sensory prediction errors, defined as the difference between the planned and the actual movement of the cursor, drive implicit learning processes, target errors (e.g., the distance of the cursor from the target) are thought to drive exp...

journal_title：Journal of neurophysiology

authors： Reichenthal M,Avraham G,Karniel A,Shmuelof L

更新日期：2016-08-01 00:00:00

abstract：:A previous neurophysiological investigation demonstrated an increase in functional projections of expiratory bulbospinal neurons (EBSNs) in the segment above a chronic lateral thoracic spinal cord lesion that severed their axons. We have now investigated how this plasticity might be manifested in thoracic motoneurons ...

journal_title：Journal of neurophysiology

authors： Ford TW,Anissimova NP,Meehan CF,Kirkwood PA

更新日期：2016-01-01 00:00:00