Use of galvanic vestibular feedback to control postural orientation in decerebrate rabbits.

Abstract:

:In quadrupeds, the dorsal-side-up body orientation during standing is maintained due to a postural system that is driven by feedback signals coming mainly from limb mechanoreceptors. In caudally decerebrated (postmammillary) rabbits, the efficacy of this system is considerably reduced. In this paper, we report that the efficacy of postural control in these animals can be restored with galvanic vestibular stimulation (GVS) applied transcutaneously to the labyrinths. In standing intact rabbits, GVS causes a lateral body sway towards the positive electrode. We used this GVS-caused sway to counteract the lateral body sway resulting from a mechanical perturbation of posture. Experiments were performed on postmammillary rabbits that stood on the tilting platform with their hindlimbs. To make the GVS value dependent on the postural perturbation (i.e., on the lateral body sway caused by tilt of the platform), an artificial feedback loop was formed in the following ways: 1) Information about the body sway was provided by a mechanical sensor; 2) The GVS current was applied when the sway exceeded a threshold value; the polarity of the current was determined by the sway direction. This simple algorithm allowed the "hybrid" postural system to maintain the dorsal-side-up orientation of the hindquarters when the platform was tilted by ± 20°. Thus, an important postural function, i.e., securing lateral stability during standing, can be restored in decerebrate rabbits with the GVS-based artificial feedback. We suggest that such a control system can compensate for the loss of lateral stability of various etiologies, and can be used for restoration of balance control in patients with impaired postural functions.

journal_name

J Neurophysiol

authors

Zelenin PV,Hsu LJ,Orlovsky GN,Deliagina TG

doi

10.1152/jn.00042.2012

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

3020-6

issue

11

eissn

0022-3077

issn

1522-1598

pii

jn.00042.2012

journal_volume

107

pub_type

杂志文章
  • Endocannabinoid-mediated depolarization-induced suppression of inhibition in hilar mossy cells of the rat dentate gyrus.

    abstract::Hilar mossy cells represent a unique population of local circuit neurons in the hippocampus and dentate gyrus. Here we use electrophysiological techniques in acute preparations of hippocampal slices to demonstrate that depolarization of a single hilar mossy cell can produce robust inhibition of local GABAergic afferen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00310.2006

    authors: Hofmann ME,Nahir B,Frazier CJ

    更新日期:2006-11-01 00:00:00

  • Noise-induced transition to bursting in responses of paddlefish electroreceptor afferents.

    abstract::The response properties of ampullary electroreceptors of paddlefish, Polyodon spathula, were studied in vivo, as single-unit afferent responses to external electrical stimulation with varied intensities of several types of noise waveforms, all Gaussian and zero-mean. They included broadband white noise, Ornstein-Uhlen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01289.2006

    authors: Neiman AB,Yakusheva TA,Russell DF

    更新日期:2007-11-01 00:00:00

  • Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex.

    abstract::1. To analyze the selectivity and the sparseness of firing to visual stimuli of single neurons in the primate temporal cortical visual area, neuronal responses were measured to a set of 68 visual stimuli in macaques performing a visual fixation task. The population of neurons analyzed had responses that occurred prima...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.713

    authors: Rolls ET,Tovee MJ

    更新日期:1995-02-01 00:00:00

  • Single-unit stability using chronically implanted multielectrode arrays.

    abstract::The use of chronic intracortical multielectrode arrays has become increasingly prevalent in neurophysiological experiments. However, it is not obvious whether neuronal signals obtained over multiple recording sessions come from the same or different neurons. Here, we develop a criterion to assess single-unit stability...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90920.2008

    authors: Dickey AS,Suminski A,Amit Y,Hatsopoulos NG

    更新日期:2009-08-01 00:00:00

  • Nonstationary noise analysis of M currents simulated and recorded in PC12 cells.

    abstract::M current relaxations recorded in PC12 cells were subjected to nonstationary noise analysis (NSNA) to obtain estimates of single-channel current (i), channel number (N), and open probability (Po) for the channels responsible for M current. The analysis was constrained such that N and single-channel conductance were th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.4.2131

    authors: Villarroel A

    更新日期:1997-04-01 00:00:00

  • NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus.

    abstract::1. We have examined the effects of iontophoresing specific antagonists to excitatory amino acid receptors on the visual responses of cells in lamina A or A1 of the cat's lateral geniculate nucleus (LGN). 2. Cells were classified as On- or Off-center, X or Y, and lagged or nonlagged. The effects of antagonists were stu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.414

    authors: Kwon YH,Esguerra M,Sur M

    更新日期:1991-08-01 00:00:00

  • Regulation of N- and L-type Ca2+ channels in adult frog sympathetic ganglion B cells by nerve growth factor in vitro and in vivo.

    abstract::To examine mechanisms responsible for the long-term regulation of Ca2+-channels in an adult neuron, changes in whole cell Ba2+ current (IBa) were examined in adult bullfrog sympathetic ganglion B cells in vitro. Cells were cultured at low density in defined, serum free medium. After 15 days, total IBa was similar to t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.6.3359

    authors: Lei S,Dryden WF,Smith PA

    更新日期:1997-12-01 00:00:00

  • Electrophysiological and morphological characteristics of layer VI pyramidal cells in the cat motor cortex.

    abstract::1. Intracellular recordings were made from layer VI pyramidal cells in in vitro slice preparations of the cat motor cortex (area 4 gamma). Layer VI pyramidal cells were identified morphologically by intracellular injection of biocytin. 2. Of 22 layer VI pyramidal cells examined, single action potentials were followed ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.2.578

    authors: Kang Y,Kayano F

    更新日期:1994-08-01 00:00:00

  • The parabrachial area: electrophysiological evidence for an involvement in visceral nociceptive processes.

    abstract::1. Neurons (n = 142) were recorded with extracellular micropipettes in the parabrachial (PB) area, in the anesthetized rat, some of them being antidromically driven from the centralis nucleus of the amygdala (Ce). The spontaneous activity of these neurons was low, (10th percentile < median frequency < 90th percentile;...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.5.1646

    authors: Bernard JF,Huang GF,Besson JM

    更新日期:1994-05-01 00:00:00

  • Processing of retinal and extraretinal signals for memory-guided saccades during smooth pursuit.

    abstract::It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00543.2004

    authors: Blohm G,Missal M,Lefèvre P

    更新日期:2005-03-01 00:00:00

  • Optical study of interactions among propagation waves of neural excitation in the rat somatosensory cortex evoked by forelimb and hindlimb stimuli.

    abstract::Multisite optical recording has revealed that the neural excitation wave induced by a sensory stimulation begins at a focus and propagates in the cortex. This wave is considered to be important for computation in the sensory cortex, particularly the integration of sensory information; however, the nature of this wave ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00904.2017

    authors: Hama N,Kawai M,Ito SI,Hirota A

    更新日期:2018-05-01 00:00:00

  • One night of partial sleep deprivation affects habituation of hypothalamus and skin conductance responses.

    abstract::Sleep disturbances are prevalent in clinical anxiety, but it remains unclear whether they are cause and/or consequence of this condition. Fear conditioning constitutes a valid laboratory model for the acquisition of normal and pathological anxiety. To explore the relationship between disturbed sleep and anxiety in mor...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00657.2013

    authors: Peters AC,Blechert J,Sämann PG,Eidner I,Czisch M,Spoormaker VI

    更新日期:2014-09-15 00:00:00

  • On the localization of complex sounds: temporal encoding based on input-slope coincidence detection of envelopes.

    abstract::Behavioral and neural findings demonstrate that animals can locate low-frequency sounds along the azimuth by detecting microsecond interaural time differences (ITDs). Information about ITDs is also available in the amplitude modulations (i.e., envelope) of high-frequency sounds. Since medial superior olivary (MSO) neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00044.2013

    authors: Gai Y,Kotak VC,Sanes DH,Rinzel J

    更新日期:2014-08-15 00:00:00

  • Postnatal development of electrical activity in the locus ceruleus.

    abstract::1. A method for adapting a standard stereotaxic frame for use with neonatal rats as young as postnatal day 1 (PD 1) was devised, and single-unit extracellular recordings were obtained from neurons in the locus ceruleus (LC) in urethan-anesthetized rats during different stages in development from PD 1 to PD 34. 2. The ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.3.510

    authors: Nakamura S,Kimura F,Sakaguchi T

    更新日期:1987-09-01 00:00:00

  • Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.

    abstract::Intense itch and urge to scratch are the major symptoms of many chronic skin ailments, which are increasingly common. Vicious itch-scratch cycles are readily established and may diminish quality of life for those afflicted. We investigated peripheral and central processing of two types of itch sensation elicited by sk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00070.2006

    authors: Leknes SG,Bantick S,Willis CM,Wilkinson JD,Wise RG,Tracey I

    更新日期:2007-01-01 00:00:00

  • Population response profiles in early visual cortex are biased in favor of more valuable stimuli.

    abstract::Voluntary and stimulus-driven shifts of attention can modulate the representation of behaviorally relevant stimuli in early areas of visual cortex. In turn, attended items are processed faster and more accurately, facilitating the selection of appropriate behavioral responses. Information processing is also strongly i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01090.2009

    authors: Serences JT,Saproo S

    更新日期:2010-07-01 00:00:00

  • Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.

    abstract::Reports of cholecystokinin (CCK) binding and expression of CCK receptors in neonatal rodent spinal cord suggest that CCK may influence neuronal excitability. In patch-clamp recordings from 19/21 ventral horn motoneurons in neonatal (PN 5-12 days) rat spinal cord slices, we noted a slowly rising and prolonged membrane ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00148.2007

    authors: Oz M,Yang KH,Shippenberg TS,Renaud LP,O'Donovan MJ

    更新日期:2007-09-01 00:00:00

  • Effect of cerebellar inactivation by lidocaine microdialysis on the vestibuloocular reflex in goldfish.

    abstract::Vestibuloocular reflex performance and adaptation were examined during vestibulocerebellar inactivation by localized lidocaine microdialysis or injection in goldfish. In the light, eye velocity perfectly compensated for head velocity (Vis-VOR) during sinusoidal yaw rotation (1/8 Hz +/- 20 degrees). In the dark, the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1286

    authors: McElligott JG,Beeton P,Polk J

    更新日期:1998-03-01 00:00:00

  • Two-tone suppression in the basilar membrane of the cochlea: mechanical basis of auditory-nerve rate suppression.

    abstract::1. The vibratory response to two-tone stimuli was measured in the basilar membrane of the chinchilla cochlea by means of the Mössbauer technique or laser velocimetry. Measurements were made at sites with characteristic frequency (CF, the frequency at which an auditory structure is most sensitive) of 7-10 kHz, located ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.4.1087

    authors: Ruggero MA,Robles L,Rich NC

    更新日期:1992-10-01 00:00:00

  • Dynamics of reflex cocontraction in hermit crab abdomen: experiments and a systems model.

    abstract::1. Both stretch and release of the ventral superficial muscles (VSM) in the abdomen of the hermit crab, Pagurus pollicarus, activate the VSM motoneurons in the intact animal and in the isolated abdomen. 2. This reflex was studied by recording intracellularly from muscle fibers innervated by single motoneurons during s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.6.1904

    authors: Chapple WD

    更新日期:1993-06-01 00:00:00

  • Differential neurotrophic regulation of sodium and calcium channels in an adult sympathetic neuron.

    abstract::Adult neuronal phenotype is maintained, at least in part, by the sensitivity of individual neurons to a specific selection of neurotrophic factors and the availability of such factors in the neurons' environment. Nerve growth factor (NGF) increases the functional expression of Na(+) channel currents (I(Na)) and both N...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00966.2007

    authors: Ford CP,Wong KV,Lu VB,Posse de Chaves E,Smith PA

    更新日期:2008-03-01 00:00:00

  • Formal and attribute-specific information in primary visual cortex.

    abstract::We estimate the rates at which neurons in the primary visual cortex (V1) of anesthetized macaque monkeys transmit stimulus-related information in response to three types of visual stimulus. The stimuli-randomly modulated checkerboard patterns, stationary sinusoidal gratings, and drifting sinusoidal gratings-have very ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.1.305

    authors: Reich DS,Mechler F,Victor JD

    更新日期:2001-01-01 00:00:00

  • Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation.

    abstract::An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as be...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.01065.2015

    authors: McGinn MA,Pahng AR

    更新日期:2017-02-01 00:00:00

  • Differential activation of lumbar and sacral motor pools during walking at different speeds and slopes.

    abstract::Organization of spinal motor output has become of interest for investigating differential activation of lumbar and sacral motor pools during locomotor tasks. Motor pools are associated with functional grouping of motoneurons of the lower limb muscles. Here we examined how the spatiotemporal organization of lumbar and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00167.2019

    authors: Dewolf AH,Ivanenko YP,Zelik KE,Lacquaniti F,Willems PA

    更新日期:2019-08-01 00:00:00

  • Glutamate-induced long-term potentiation enhances spontaneous EPSC amplitude but not frequency.

    abstract::1. Many examples of long-term potentiation (LPT) are induced by repetitive electrical stimulation of presynaptic axons. LTP also is induced by direct glutamate iontophoresis (1 M, 1-2 microA, 10 s) onto postsynaptic neurons in hippocampal slices without evoked presynaptic stimulation; this form of LTP is called "ionto...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.5.1909

    authors: Cormier RJ,Kelly PT

    更新日期:1996-05-01 00:00:00

  • Defense reaction in the pond snail Planorbis corneus. III. Response to input from statocysts.

    abstract::1. In the intact pond snail Planorbis corneus, a rapid tilt in any plane evoked a defense reaction consisting of a fast movement of the shell towards the head, shortening of the foot, inhibition of locomotion and of rhythmical feeding movements. This reaction was similar to the first phase of the general defense react...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.3.898

    authors: Arshavsky YI,Deliagina TG,Okshtein IL,Orlovsky GN,Panchin YV,Popova LB

    更新日期:1994-03-01 00:00:00

  • Functional properties of neurons in the primate tongue primary motor cortex during swallowing.

    abstract::Recent studies conducted in our laboratory have suggested that the tongue primary motor cortex (i.e., tongue-MI) plays a critical role in the control of voluntary tongue movements in the primate. However, the possible involvement of tongue-MI in semiautomatic tongue movements, such as those in swallowing, remains unkn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.3.1516

    authors: Martin RE,Murray GM,Kemppainen P,Masuda Y,Sessle BJ

    更新日期:1997-09-01 00:00:00

  • Response properties of neurons in primary somatosensory cortex of owl monkeys reflect widespread spatiotemporal integration.

    abstract::Receptive fields of neurons in somatosensory area 3b of monkeys are typically described as restricted to part of a single digit or palm pad. However, such neurons are likely involved in integrating stimulus information from across the hand. To evaluate this possibility, we recorded from area 3b neurons in anesthetized...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00709.2009

    authors: Reed JL,Qi HX,Zhou Z,Bernard MR,Burish MJ,Bonds AB,Kaas JH

    更新日期:2010-04-01 00:00:00

  • Positive force feedback control of muscles.

    abstract::This study was prompted by recent evidence for the existence of positive force feedback in feline locomotor control. Our aim was to establish some basic properties of positive force feedback in relation to load compensation, stability, intrinsic muscle properties, and interaction with displacement feedback. In human s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.6.3226

    authors: Prochazka A,Gillard D,Bennett DJ

    更新日期:1997-06-01 00:00:00

  • Effects of brain stem parabrachial activation on receptive field properties of cells in the cat's lateral geniculate nucleus.

    abstract::1. The lateral geniculate nucleus is the primary thalamic relay for the transfer of retinal signals to the visual cortex. Geniculate cells are heavily innervated from nonretinal sources, and these modify retinogeniculate transmission. A major ascending projection to the lateral geniculate nucleus arises from cholinerg...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.6.2428

    authors: Uhlrich DJ,Tamamaki N,Murphy PC,Sherman SM

    更新日期:1995-06-01 00:00:00