Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: potentiation of mitoxantrone cytotoxicity.

abstract：OBJECTIVES:Determinants of endometrial cancer grade have not been precisely defined, however, cell cycle control is considered to be integrally involved in endometrial cancer development. TP53 and MDM2 are essential components for cell cycle arrest and apoptosis. Polymorphisms in these genes cause TP53 inactivation and...

journal_title：Gynecologic oncology

authors： Ashton KA,Proietto A,Otton G,Symonds I,McEvoy M,Attia J,Gilbert M,Hamann U,Scott RJ

更新日期：2009-04-01 00:00:00

abstract：:The response rate and the determinants of response to a cisplatin-based regimen of neodjuvant chemotherapy (NACT) in women with a histologically confirmed first-diagnosis of invasive bulky stage IB-IIB cervical cancer are analyzed. A total of 79 cases were treated with cisplatin (40 mg/m2) each 7 days for seven course...

journal_title：Gynecologic oncology

authors： Bolis G,van Zainten-Przybysz I,Scarfone G,Zanaboni F,Scarabelli C,Tateo S,Calabrese M,Parazzini F

更新日期：1996-10-01 00:00:00

abstract：:Homeobox (HOX) genes are a family of transcription factors that are essential regulators of development. HOX genes play important roles in normal reproductive physiology, as well as in the development and progression of serous carcinomas, the predominant and most aggressive subtype of epithelial ovarian cancer (EOC). ...

journal_title：Gynecologic oncology

authors： Miller KR,Patel JN,Ganapathi MK,Tait DL,Ganapathi RN

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The goal of this work was to evaluate the involvement of gonadotropins in the regulation of adhesion of human epithelial ovarian carcinoma. We studied two pathways that were previously implicated in the metastatic implantation of ovarian carcinoma to the peritoneum, namely hyaluronan-CD44 and RGD-integrin med...

journal_title：Gynecologic oncology

authors： Schiffenbauer YS,Meir G,Maoz M,Even-Ram SC,Bar-Shavit R,Neeman M

更新日期：2002-02-01 00:00:00

abstract：:Ninety-six patients with cervical cancer underwent surgical staging prior to radiation therapy. An equal number of patients were explored by transperitoneal and extraperitoneal surgery. Three different extraperitoneal approaches were utilized. All patients had bilateral paraaortic lymphadenectomy and selective pelvic ...

journal_title：Gynecologic oncology

authors： LaPolla JP,Schlaerth JB,Gaddis O,Morrow CP

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate clinical manifestations, management options, and prognosis for women presenting with gestational trophoblastic tumors with vaginal metastasis. METHOD:Fifty-one patients with vaginal metastases were analyzed retrospectively between January 1985 and September 2000. Vaginal...

journal_title：Gynecologic oncology

authors： Yingna S,Yang X,Xiuyu Y,Hongzhao S

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:The aims of this study were (1) to examine whether HPV DNA is persistently detected in the cervix after therapeutic conization for CIN 3 and (2) to explore whether a patient with persistence of HPV infection is at risk of developing recurrent disease. METHODS:Of 74 patients referred with CIN 3, 58 who were t...

journal_title：Gynecologic oncology

authors： Nagai Y,Maehama T,Asato T,Kanazawa K

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The long-term survival of patients with epithelial ovarian cancer is limited by the emergence of tumor cells that are resistant to chemotherapy. We hypothesized that expression of Bcl-x(L), a homologue of Bcl-2 that confers protection from chemotherapy-induced apoptosis, may be predictive of patients' clinica...

journal_title：Gynecologic oncology

authors： Williams J,Lucas PC,Griffith KA,Choi M,Fogoros S,Hu YY,Liu JR

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the risk of malignancy in cystic ovarian tumors < 10 cm in diameter in asymptomatic postmenopausal women or women >or =50 years of age. METHODS:All cystic ovarian tumors detected by transvaginal sonography screening in asymptomatic postmenopausal women or women > or =50...

journal_title：Gynecologic oncology

authors： Bailey CL,Ueland FR,Land GL,DePriest PD,Gallion HH,Kryscio RJ,van Nagell JR Jr

更新日期：1998-04-01 00:00:00

abstract：:All patients with bulky (> or =4 cm) Stage Ib or IIa cervical carcinoma treated at Chang Gung Memorial Hospital between August 1988 and December 1991 using a strategy of neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical hysterectomy were reviewed. Fifty-nine evaluable patients received 1 ...

journal_title：Gynecologic oncology

authors： Lai CH,Hsueh S,Chang TC,Tseng CJ,Huang KG,Chou HH,Chen SM,Chang MF,Shum HC

更新日期：1997-03-01 00:00:00

abstract：:Near-infrared (NIR) fluorescence imaging has emerged as a promising complimentary technique for intraoperative visualization of tumor tissue, lymph nodes and vital structures. In this review, the current applications and future opportunities of NIR fluorescence imaging in gynecologic oncology are summarized. Several s...

journal_title：Gynecologic oncology

authors： Handgraaf HJ,Verbeek FP,Tummers QR,Boogerd LS,van de Velde CJ,Vahrmeijer AL,Gaarenstroom KN

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) is commonly used to detect occult or recurrent malignancy, including tumors of the female genital tract. Recently, there have been reports of PET scans used in patients with Gestational Trophoblastic Disease (GTD). CASE:A 22-year-old female presented with vaginal bleeding ...

journal_title：Gynecologic oncology

authors： Numnum TM,Leath CA 3rd,Straughn JM Jr,Conner MG,Barnes MN 3rd

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Improved treatment for advanced cervical cancer is needed; currently, treatment options include combined chemotherapy and bevacizumab or pembrolizumab monotherapy for PD-L1 positive disease. PIK3CA and KRAS mutations have been reported in cervical cancers; this study therefore tested dual inhibition of PI3K ...

journal_title：Gynecologic oncology

authors： Liu JF,Gray KP,Wright AA,Campos S,Konstantinopoulos PA,Peralta A,MacNeill K,Morrissey S,Whalen C,Dillon D,Matulonis UA

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:The utility of parametrial resection in women with early stage cervical cancer is controversial. In patients with favorable pathologic characteristics such as tumor size <2cm and the absence of lymphovascular space invasion, the rate of parametrial involvement is very low. More conservative surgical approach...

journal_title：Gynecologic oncology

authors： Schmeler KM,Frumovitz M,Ramirez PT

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The present study aimed to evaluate the association between altered methylation and histologically confirmed high grade cervical intraepithelial neoplasia (hgCIN). METHODS:Methylation levels in selected host (CADM1, MAL, DAPK1) and HPV (L1_I, L1_II, L2) genes were measured by pyrosequencing in DNA samples ob...

journal_title：Gynecologic oncology

authors： Fiano V,Trevisan M,Fasanelli F,Grasso C,Marabese F,da Graça Bicalho M,de Carvalho NS,Maestri CA,Merletti F,Sacerdote C,De Marco L,Gillio-Tos A

更新日期：2018-11-01 00:00:00

abstract：:Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...

journal_title：Gynecologic oncology

authors： Simonsen E,Johnsson JE,Tropé C

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The purpose was to examine the outcomes of patients with advanced ovarian cancer treated with neoadjuvant chemotherapy, with a special emphasis on the patients' quality of life (QOL). METHODS:Seventeen patients with advanced ovarian cancer were treated with neoadjuvant chemotherapy based on the extent of dis...

journal_title：Gynecologic oncology

authors： Chan YM,Ng TY,Ngan HY,Wong LC

更新日期：2003-01-01 00:00:00

abstract：:Progress has been made in identifying the molecular changes that occur in ovarian carcinoma; still our understanding of these changes and their interactions remains incomplete. In the present study the authors examined the expression of retinoblastoma protein, a tumor suppressor protein, in a spectrum of ovarian epith...

journal_title：Gynecologic oncology

authors： Niemann TH,Trgovac TL,McGaughy VR,Lewandowski GS,Copeland LJ

更新日期：1998-06-01 00:00:00

abstract：INTRODUCTION:Focused ultrasound under real-time MR guidance and control (MRgFUS) can be used for the thermal ablation of tissue. Currently this technique is used clinically for the noninvasive treatment of uterine leiomyomas and is in clinical evaluation for breast cancer, adenomyosis and other indications. MRgFUS is b...

journal_title：Gynecologic oncology

authors： Machtinger R,Inbar Y,Ben-Baruch G,Korach J,Rabinovici J

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:High-risk (HR) human papillomavirus (HPV) testing is important in cervical cancer screening for triage to colposcopy. This study evaluated the clinical performance of the Cervista HPV HR and 16/18 genotyping tests for detection of HPV in cervical cytology specimens. METHODS:The tests were prospectively evalu...

journal_title：Gynecologic oncology

authors： Einstein MH,Martens MG,Garcia FA,Ferris DG,Mitchell AL,Day SP,Olson MC

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to elucidate the expression and the correlation of two cell cycle regulators, cdk4 and its inhibitor p16, in a series of benign, borderline, and malignant ovarian tumors and to evaluate whether their alterations correlate with clinicopathologial parameters and patients' prognosis in...

journal_title：Gynecologic oncology

authors： Sui L,Dong Y,Ohno M,Goto M,Inohara T,Sugimoto K,Tai Y,Hando T,Tokuda M

更新日期：2000-11-01 00:00:00

abstract：:A patient with three synchronous, Stage I neoplasms of the ovary, kidney, and lung, who underwent resection of all lesions at the same operative procedure, is presented. The incidence of multiple primary malignancies and the prognosis for Stage I cancers of the ovary, kidney, and lung are reviewed. ...

journal_title：Gynecologic oncology

authors： Ringler GE,Senekjian EK,Smith FL,Little AG,Clinton S,Stephens JK

更新日期：1989-04-01 00:00:00

abstract：:Adenocarcinoma of the urethra is a rare neoplasm which is believed to arise from the periurethral ducts. Four such cases have been diagnosed at our institution during the past 25 years and their clinical courses are summarized in this report. In one patient, a disseminated coagulopathy with a predominantly fibrinolyti...

journal_title：Gynecologic oncology

authors： Taylor RN,Lacey CG,Shuman MA

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Traditionally, hysterectomy is considered definitive therapy for cervical adenocarcinoma in situ (AIS) in women beyond childbearing. CASE:A 45-year-old gravida 2, para 2 patient presented with cervical dysplasia and on pathology review of the large loop excision procedure cervical adenocarcinoma in situ was...

journal_title：Gynecologic oncology

authors： Miller B,Dunn J,Dalrymple J,Krivak TC

更新日期：2005-11-01 00:00:00

abstract：UNLABELLED:Despite the publication of two dozen observational epidemiological studies investigating the association between recreational physical activity (RPA) and epithelial ovarian cancer (EOC) risk and survival over the past two decades, taken collectively, data from retrospective and prospective studies are mixed ...

journal_title：Gynecologic oncology

authors： Cannioto RA,Moysich KB

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Current therapy for cervical cancer includes radiation therapy. Retinoic acid (RA) can increase the sensitivity of cervical cancer cell lines to radiation. The mechanism of this sensitization may not involve the p53 protein because the human papillomavirus (HPV) E6 protein, which is present in the majority of...

journal_title：Gynecologic oncology

authors： Tillmanns TD,Kamelle SA,Guruswamy S,Gould NS,Rutledge TL,Benbrook DM

更新日期：2005-04-01 00:00:00

abstract：:Thirty-three patients with locally advanced carcinoma of the cervix were treated with chemotherapy as first line treatment. Great emphasis was applied to document, in the most objective manner, the tumor size response. The first 8 patients received a conventional scheme composed of vincristine, bleomycin and cis-plati...

journal_title：Gynecologic oncology

authors： Sardi JE,di Paola GR,Cachau A,Ortiz OC,Sananes C,Giaroli A,Martins D,Peluffo M

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:To increase genetic counseling referrals for patients with newly diagnosed epithelial ovarian cancer (EOC). METHODS:A practice-gap analysis was performed after measuring baseline genetic counseling referral rates to identify barriers to referral from the multidisciplinary single institution EOC care group. A...

journal_title：Gynecologic oncology

authors： Swanson CL,Kumar A,Maharaj JM,Kemppainen JL,Thomas BC,Weinhold MR,Slaby KM,Mara KC,Wick MJ,Bakkum-Gamez JN

更新日期：2018-04-01 00:00:00