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MicroRNA-212-5p regulates the inflammatory response of periodontal ligament cells by targeting myeloid differentiation factor 88.

Abstract：

OBJECTIVE:This study was aimed to investigate the effects of microRNA-212-5p (miR-212-5p) and myeloid differentiation factor 88 (Myd88) in Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS)-challenged human periodontal ligament cells (PDLCs). METHODS:The levels of miR-212-5p and Myd88 in PDLCs were determined via quantitative real-time Polymerase Chain Reaction. Cell viability and pro-inflammatory cytokines were assessed using MTT assay and enzyme-linked immunosorbent assay. Bioinformatics and luciferase reporter gene assay were employed to explore the interaction between miR-212-5p and Myd88. Moreover, the activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B signal pathways were testified via western blot analysis. RESULTS:MiR-212-5p was downregulated following stimulation of P. gingivalis LPS. Overexpression of miR-212-5p elevated the cell viability and reduced the secretion of pro-inflammatory cytokines. Myd88 is a target of miR-212-5p. Notably, pcDNA3.1-Myd88 reversed the anti-inflammatory effect of miR-212-5p overexpression. Likewise, miR-212-5p mimic inhibited the activation of p38 MAPK and nuclear factor kappa-B, whereas pcDNA3.1-Myd88 abrogated the effect of miR-212-5p mimic. CONCLUSIONS:MiR-212-5p inhibited the inflammatory response in PDLCs by targeting Myd88, which may involve the inactivation of p38 MAPK and nuclear factor kappa-B.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Hua B,Xiang J,Guo L,Lu D

doi

10.1016/j.archoralbio.2020.104831

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

104831

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(20)30209-0

journal_volume

118

pub_type

杂志文章

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