Central amylin acts as an adiposity signal to control body weight and energy expenditure.

Abstract:

:The pancreatic B-cell hormone amylin has been proposed to be both a satiation signal and an adiposity signal. The effects of peripheral amylin on energy balance are well investigated, but the effects of central amylin are less clear. We determined the effects of low doses of amylin administered into the 3rd cerebral ventricle (i3vt) on food intake, body weight and other indices of energy balance. Amylin (2 pmol/h) significantly lowered body weight compared to saline after 2 weeks of infusion, independent of whether prior body weight was decreased by fasting, increased by voluntary overfeeding or unmanipulated. A bolus injection of amylin (10 pmol, i3vt) increased energy expenditure and body temperature, whereas chronic i3vt amylin infusion had no effect on energy expenditure above that of control rats even though body temperature was increased. Chronic amylin also reduced RQ, implying a preferential oxidation of fat. Overall, the data provide new evidence that amylin is an adiposity signal that acts within the brain, and informing the brain about the status of peripheral energy stores.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Wielinga PY,Löwenstein C,Muff S,Munz M,Woods SC,Lutz TA

doi

10.1016/j.physbeh.2010.04.012

subject

Has Abstract

pub_date

2010-08-04 00:00:00

pages

45-52

issue

1

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(10)00170-8

journal_volume

101

pub_type

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