Neural mechanisms underlying spatial realignment during adaptation to optical wedge prisms.

Abstract:

:Visuomotor adaptation to a shift in visual input produced by prismatic lenses is an example of dynamic sensory-motor plasticity within the brain. Prism adaptation is readily induced in healthy individuals, and is thought to reflect the brain's ability to compensate for drifts in spatial calibration between different sensory systems. The neural correlate of this form of functional plasticity is largely unknown, although current models predict the involvement of parieto-cerebellar circuits. Recent studies that have employed event-related functional magnetic resonance imaging (fMRI) to identify brain regions associated with prism adaptation have discovered patterns of parietal and cerebellar modulation as participants corrected their visuomotor errors during the early part of adaptation. However, the role of these regions in the later stage of adaptation, when 'spatial realignment' or true adaptation is predicted to occur, remains unclear. Here, we used fMRI to quantify the distinctive patterns of parieto-cerebellar activity as visuomotor adaptation develops. We directly contrasted activation patterns during the initial error correction phase of visuomotor adaptation with that during the later spatial realignment phase, and found significant recruitment of the parieto-cerebellar network--with activations in the right inferior parietal lobe and the right posterior cerebellum. These findings provide the first evidence of both cerebellar and parietal involvement during the spatial realignment phase of prism adaptation.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Chapman HL,Eramudugolla R,Gavrilescu M,Strudwick MW,Loftus A,Cunnington R,Mattingley JB

doi

10.1016/j.neuropsychologia.2010.05.006

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

2595-601

issue

9

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(10)00185-5

journal_volume

48

pub_type

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