Abstract:
:Amnesia leads to a deficit in recollection that leaves familiarity-based recognition relatively spared. Familiarity is thought to be based on the fluent processing of studied items compared to novel items. However, whether amnesic patients respond normally to direct manipulations of processing fluency is not yet known. In the current study, we manipulated processing fluency by preceding each test item with a semantically related or unrelated prime item, and measured both recollection and familiarity using a remember-know recognition procedure. In healthy controls, enhancing processing fluency increased familiarity-based recognition responses for both old and new words, leaving familiarity-based accuracy constant. However, in patients with MTL damage, enhancing fluency only increased familiarity-based recognition responses for new items, resulting in decreased familiarity-based recognition accuracy. Importantly, this fluency-related decrease in recognition accuracy was not due to overall lower levels of performance or impaired recollection of studied items because it was not observed in healthy subjects that studied words under conditions that lowered performance by reducing recollection. The results indicate that direct manipulations of processing fluency can disrupt familiarity-based discrimination in amnesia. Potential accounts of these findings are discussed.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Ozubko JD,Yonelinas APdoi
10.1016/j.neuropsychologia.2013.12.008subject
Has Abstractpub_date
2014-02-01 00:00:00pages
59-67eissn
0028-3932issn
1873-3514pii
S0028-3932(13)00438-7journal_volume
54pub_type
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