Abstract:
:In the human, canonical histones are largely replaced by protamine 1 (P1) and protamine 2 (P2) during late spermatogenesis. Recent studies have demonstrated that abnormal replacement of the histones is associated with severe male infertility and has profound implications for early embryogenesis. In this review the hispid cotton rat and the common marmoset are evaluated as animal models for the study of chromatin packaging in sperm. The DNA sequences of protamine 1 and protamine 2 in the cotton rat are also reported. We have found that the P1 and P2 genes share a 64% and 56% amino acid identity with human, respectively. The hispid cotton rat expresses both protamines, has a similar P1:P2 ratio, and a gene sequence homologous to human, thus making it a possible model organism for chromatin studies. The common marmoset also expresses both protamine genes and has a very similar spermatogenetic characteristic to man. This review considers both animals as possible models to study the mechanisms of protamine regulation and the effects of altered expression caused by environmental or physiological perturbations.
journal_name
Syst Biol Reprod Medjournal_title
Systems biology in reproductive medicineauthors
Nanassy L,Griffin J,Emery BR,Carrell DTdoi
10.3109/19396361003653311subject
Has Abstractpub_date
2010-06-01 00:00:00pages
207-12issue
3eissn
1939-6368issn
1939-6376journal_volume
56pub_type
杂志文章,评审abstract::Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2011.637152
更新日期:2012-02-01 00:00:00
abstract::Increased trophoblast apoptosis has been implicated in pregnancies complicated by fetal growth restriction and preeclampsia (EC). We investigated placenta growth factor (PLGF) signaling during trophoblast apoptosis in culture and X-linked inhibitor of apoptosis protein (XIAP) and apoptosis inducible factor (AIF) in th...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.927540
更新日期:2014-10-01 00:00:00
abstract::The GIRK2-containing inward-rectifying K(+) ion channels have been implicated in mammalian spermatogenesis. While the Girk2 null mice are fertile, the male weaver transgenic mice carrying a gain-of-function mutation in the Girk2 gene are infertile. To establish the exact period of spermatogenesis affected by this muta...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2011.631685
更新日期:2011-12-01 00:00:00
abstract::Phthalates are ubiquitous industrial chemicals that are reported to adversely affect human reproductive outcomes. Divergent effects on semen quality have been reported in a limited number of studies. To assess the possible contribution of regional differences in phthalate exposure to these results, we wished to determ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360802055921
更新日期:2008-05-01 00:00:00
abstract::The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies b...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1806944
更新日期:2020-12-01 00:00:00
abstract::To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptak...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1341962
更新日期:2017-10-01 00:00:00
abstract::During spermatogenesis, changes in sperm nuclear morphology are associated with the replacement of core somatic histones by protamines. Although protamines are the major nucleoproteins of mature sperm, not all species totally replace the histones. Histone H1, along with protamines, mediates chromatin condensation into...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360802357087
更新日期:2008-11-01 00:00:00
abstract::Sexual dysfunction is one of the diabetic complications in males. The present study aimed to evaluate the antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin (STZ) induced diabetic male rats. Male Wistar rats were divided as control, diabetic control, diabetic rats admini...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2013.820369
更新日期:2013-12-01 00:00:00
abstract::We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA was extracted. The differentially expressed P...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.889774
更新日期:2014-06-01 00:00:00
abstract::Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intra-testicular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (>3...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396360902787944
更新日期:2009-03-01 00:00:00
abstract::The understanding of the early mammalian development is a prerequisite for the advancement of in vitro fertilization and improvement of derivation and culturing of embryonic stem cells. While, whole genome transcriptomic analysis on bovine blastocysts has identified genes active in early development, little informatio...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2014.894152
更新日期:2014-06-01 00:00:00
abstract::Both microdrop and open methods are commonly used for in vitro fertilization (IVF) protocols for embryo culture as well as oocyte insemination. However, few comparative studies evaluating the microdrop or open method of insemination on the fertilization outcome and subsequent embryo development have been performed. A ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,随机对照试验
doi:10.3109/19396368.2013.872707
更新日期:2014-06-01 00:00:00
abstract::Artificial insemination has achieved a dynamic increase in genetic progress, and this is due to the improvement of sperm preservation technology. In recent years, a lot of attention has been paid to optimizing bull sperm storage environment and objectifying methods of sperm quality analysis. This review presents bull ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2020.1795432
更新日期:2020-10-01 00:00:00
abstract::Spermatogenesis is a highly sophisticated process involved in the transmission of genetic heritage. It includes halving ploidy, repackaging of the chromatin for transport, and the equipment of developing spermatids and eventually spermatozoa with the advanced apparatus (e.g., tightly packed mitochondrial sheat in the ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2012.691943
更新日期:2012-08-01 00:00:00
abstract::Sperm progressive motility has been reported to be one of the key factors influencing in vitro fertilization rates. However, recent studies have shown that sperm DNA fragmentation is a more robust predictor of assisted reproductive outcomes including reduced fertilization rates, embryo quality, and pregnancy rates. Th...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2011.553984
更新日期:2011-06-01 00:00:00
abstract::Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Se...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1291767
更新日期:2017-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396360902896844
更新日期:2009-08-01 00:00:00
abstract::Genomic disorders are defined as diseases caused by rearrangements of the genome incited by a genomic architecture that conveys instability. Y-chromosome related dysfunctions such as male infertility are frequently associated with gross DNA rearrangements resulting from its peculiar genomic architecture. The Y-chromos...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2010.527427
更新日期:2011-02-01 00:00:00
abstract::A very common conception about the function of the spermatozoon is that its unique role is to transmit the paternal genome to the next generation. Most of the sperm genome is known to be condensed in many species by protamines, which are small and extremely positively charged proteins (50-70% arginine) with the functi...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2018.1482383
更新日期:2018-12-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2015.1041622
更新日期:2015-01-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396368.2013.780644
更新日期:2013-06-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2016.1232447
更新日期:2016-12-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.3109/19396360903244598
更新日期:2010-04-01 00:00:00
abstract::Pulsatile secretion of hormones in the hypothalamic-pituitary-gonadal axis is critical for normal functioning of the reproductive system. Thus, appropriate characterization of pulsatile secretion is important for identifying the (patho)physiology of reproductive conditions. Existing analysis methods often fail to adeq...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1411541
更新日期:2018-02-01 00:00:00
abstract::Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from succ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2017.1410866
更新日期:2018-02-01 00:00:00
abstract::Assisted reproductive technology has evolved tremendously since the emergence of in vitro fertilization (IVF). In the course of the recent decade, there have been significant efforts in order to minimize multiple gestations, while improving percentages of singleton pregnancies and offering individualized services in I...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1080/19396368.2018.1504347
更新日期:2018-10-01 00:00:00
abstract::Spermatozoa contain a complex population of RNAs including messenger RNAs (mRNAs) and small RNAs such as microRNAs (miRNA). It has been reported that these RNAs can be used to understand the mechanisms by which toxicological exposure affects spermatogenesis. The aim of our study was to compare mRNA and miRNA profiles ...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.3109/19396368.2015.1022835
更新日期:2015-06-01 00:00:00
abstract::We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
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journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2016.1177619
更新日期:2016-08-01 00:00:00
abstract::Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating an...
journal_title:Systems biology in reproductive medicine
pub_type: 杂志文章
doi:10.1080/19396368.2018.1519047
更新日期:2019-06-01 00:00:00