Multiple pH measurement during storage may detect bacterially contaminated platelet concentrates.

abstract：BACKGROUND:In the 20th century, blood transfusion has become an indispensable therapy in carrying out and improving many medical and surgical applications. Its scope of influence goes well beyond that of medicine, because blood donation, an action with high social significance, is completely connected to progress in th...

journal_title：Transfusion

authors： Danic B,Lefrère JJ

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Idarucizumab (IDA) is approved for emergency reversal of dabigatran; prothrombin complex concentrates (PCCs) are recommended in the absence of specific antidote. The combined effects of IDA and PCC in trauma-related bleeding are unknown. The efficacy and safety of combined IDA + PCC were assessed in a lethal...

journal_title：Transfusion

authors： Honickel M,Braunschweig T,Rossaint R,Schöchl H,Grottke O

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Ultrasound-facilitated delivery of topical anesthetics has been used to achieve effective anesthesia within 5 minutes for venipuncture and the insertion of intravenous access devices, but has never been studied for blood donation. STUDY DESIGN AND METHODS:This study was a single-center, prospective, randomi...

journal_title：Transfusion

authors： Stowell CP,Trieu MQ,Chuang H,Katz N,Quarrington C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The mechanism of action of anti-D in ameliorating immune thrombocytopenia (ITP) remains unclear. The monoclonal antibody (MoAb) Ter119, which targets murine red blood cells (RBCs), has been shown to mimic the effect of anti-D in improving antibody-mediated murine ITP. The mechanism of Ter119-mediated ITP ame...

journal_title：Transfusion

authors： Yu X,Menard M,Seabright G,Crispin M,Lazarus AH

更新日期：2015-06-01 00:00:00

abstract：:The in vivo viability and functional integrity of filtered platelets were compared with those of nonfiltered platelets in a controlled study. On two occasions, after template bleeding time, 14 healthy volunteers underwent plateletpheresis and received 600 mg of aspirin. Autologous 111In-labeled platelets were transfus...

journal_title：Transfusion

authors： Brecher ME,Pineda AA,Zylstra-Halling VW,Chowdhury S,Forstrom LA

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Thrombotic microangiopathies (TMA) are systemic vasoocclusive disorders associated with significant morbidity and mortality. Rapid and reliable diagnosis of TMA is critical. The diagnosis is complicated by a lack of objective and sensitive laboratory testing as well as multiple concurrent diseases, including...

journal_title：Transfusion

authors： Dwyre DM,Bell AM,Siechen K,Sethi S,Raife TJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:There is scope to further improve the safety of transfusion practice within the United Kingdom. This study aims to identify the current role of junior doctors in the transfusion process and to assess their competency to appropriately prescribe blood and blood products to patients. STUDY DESIGN AND METHODS:T...

journal_title：Transfusion

authors： Graham J,Grant-Casey J,Alston R,Baker P,Pendry K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Acute trauma coagulopathy (ATC) after military trauma has not been comprehensively studied. ATC is defined as a prolonged prothrombin time ratio (PTr) or reduced clot amplitude (A5) in viscoelastic testing. Compared to civilian trauma, military trauma has more injuries from explosions and gunshot wounds (GSW...

journal_title：Transfusion

authors： Woolley T,Gwyther R,Parmar K,Kirkman E,Watts S,Midwinter M,Lucca JD,Hunt BJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Antibodies specific for the neutrophil antigen HNA-3a cause severe, sometimes fatal transfusion-related acute lung disease (TRALI) when transfused, but it has not been possible to screen blood donors for anti-HNA-3a because using neutrophils as targets was impractical and molecular properties of the antigen ...

journal_title：Transfusion

authors： Curtis BR,Sullivan MJ,Holyst MT,Szabo A,Bougie DW,Aster RH

更新日期：2011-10-01 00:00:00

abstract：:The enzyme-linked antiglobulin test was used to determine the percentage of antibody removed from sensitized red cells by five elution methods: Rubin ether, xylene, digitonin-acid, glycine, and heat. Antibodies examined in the study included anti-D, -c, -E, and -K. With two examples of anti-D, more antibody was eluted...

journal_title：Transfusion

authors： Gibble JW,Salamon JL,Ness PM

更新日期：1983-07-01 00:00:00

abstract：:We have estimated the risk of transmitting HIV infection from a unit of HIV seronegative blood collected in Los Angeles and Orange Counties, CA from March 1985 through February 1987. Our method consisted of lookback investigations and anti-HIV testing of living recipients of HIV seronegative units donated by persons w...

journal_title：Transfusion

authors： Kleinman S,Secord K

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:When bacteria are found, after a platelet transfusion, in the recipient's blood as well as in the platelet concentrate (PC), a causal relationship is normally suspected, with the PC as the causative agent. The other alternative, that the patient has bacteremia and contaminated the PC, is less well documented...

journal_title：Transfusion

authors： Engstrand M,Engstrand L,Högman CF,Hambraeus A,Branth S

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life-long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to e...

journal_title：Transfusion

authors： Kirchhoff LV,Paredes P,Lomelí-Guerrero A,Paredes-Espinoza M,Ron-Guerrero CS,Delgado-Mejía M,Peña-Muñoz JG

更新日期：2006-02-01 00:00:00

abstract：:Vancomycin, an antibiotic similar in structure to ristocetin, is used to treat staphylococcal infections. However, vancomycin-induced hemagglutination complicated red cell (RBC) serologic testing in the blood bank. At concentrations greater than 3.0 mg per ml, vancomycin caused spontaneous macroscopic red cell (RBC) a...

journal_title：Transfusion

authors： Williams L,Domen RE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Recently, a quasi-lipid-enveloped (LE) form of the traditionally nonlipid-enveloped (NLE) hepatitis A virus (HAV) was described in human serum and cell culture-derived HAV stocks. This discovery challenges the understanding of HAV reduction in virus clearance studies of plasma products, which were performed ...

journal_title：Transfusion

authors： Kapsch AM,Farcet MR,Antoine G,Kreil TR

更新日期：2017-06-01 00:00:00

abstract：:This article introduces a new method of component preparation that is capable of producing white cell (WBC)-reduced platelet concentrates (PCs) from whole blood. Whole blood is separated into packed red cells (RBCs) and platelet-rich plasma (PRP) by centrifugation, and the PRP is expressed through a newly designed WBC...

journal_title：Transfusion

authors： Dzik WH,Cusack WF,Gacek MJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Guidelines for red blood cell (RBC) transfusions exist; however, transfusion practices vary among centers. This study aimed to analyze transfusion practices and the impact of patients and institutional characteristics on the indications of RBC transfusions in preterm infants. STUDY DESIGN AND METHODS:RBC tr...

journal_title：Transfusion

authors： dos Santos AM,Guinsburg R,Procianoy RS,Sadeck Ldos S,Netto AA,Rugolo LM,Luz JH,Bomfim O,Martinez FE,de Almeida MF,Brazilian Network on Neonatal Research.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The intrinsic properties of polypeptide blood group antigens that determine their relative immunogenicities are unknown. Because size, composition, charge, dose, and epitope glycosylation affect the immunogenicity of other polypeptides, we examined whether similar properties were related to the immunogenicit...

journal_title：Transfusion

authors： Howe JG,Stack G

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Blood bank inventories must balance adequate supply with minimal outdate rates. The day-to-day practice of ordering red blood cell (RBC) inventory usually involves manually comparing current inventory levels with predetermined thresholds calculated from historical usage and ordering the difference. To date, ...

journal_title：Transfusion

authors： Quinn J,Campbell C,Gomez A,Kumar-Misir A,Watson S,Liwski D,Covello T,Tennankore KK,Chisholm N,Sadek I,Cheng C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Severe transfusion-related acute lung injury is often caused by antibodies directed against the human neutrophil alloantigen (HNA)-3a. HNA-3a results from an amino acid exchange (Arg154Gln) in the first extracellular loop of the choline transporter-like protein 2 (CTL2). The characteristics of the binding do...

journal_title：Transfusion

authors： Berthold T,Wesche J,Kuhnert K,Fürll B,Hippe H,Hoppen J,Reil A,Muschter S,Bux J,Greinacher A

更新日期：2011-10-01 00:00:00

abstract：:Exchange transfusions using whole blood less than 24 hours old and deglycerolized red cells reconstituted with fresh-frozen plasma were performed in two premature infants for the treatment of hyperkalemia and cardiac arrhythmia. Improvement of their condition was immediate. ...

journal_title：Transfusion

authors： Lorch V,Jones FS,Hoersten IR

更新日期：1985-07-01 00:00:00

abstract：:The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, N...

journal_title：Transfusion

authors： Vostal JG,Buehler PW,Gelderman MP,Alayash AI,Doctor A,Zimring JC,Glynn SA,Hess JR,Klein H,Acker JP,Spinella PC,D'Alessandro A,Palsson B,Raife TJ,Busch MP,McMahon TJ,Intaglietta M,Swartz HM,Dubick MA,Cardin S,Patel

更新日期：2018-01-01 00:00:00

abstract：:The research process is a balance between the inherent risks of new discoveries and the risks of research participant safety. Conflicts of interest, inherent to the research process, as well as those introduced by emerging cellular therapies, have the potential to compromise safety. The relationship of trust between t...

journal_title：Transfusion

authors： Yim R

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Safe, accurate methods permitting simultaneous and/or repeated measurement of red blood cell (RBC) survival (RCS) are important to investigate pathophysiology and therapy of anemia. Methods using chromium 51 ((51) Cr)-labeled RBCs are unacceptable for infants, children, and pregnant women. We report RCS meas...

journal_title：Transfusion

authors： Mock DM,Matthews NI,Zhu S,Strauss RG,Schmidt RL,Nalbant D,Cress GA,Widness JA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUD...

journal_title：Transfusion

authors： Asenso-Mensah K,Achina G,Appiah R,Owusu-Ofori S,Allain JP

更新日期：2014-03-01 00:00:00

abstract：:Baboons were bled one-third of their blood volume and then transfused with an equivalent volume of compatible donor red blood cells with 160 per cent of normal 2,3-diphosphoglycerate (2,3-DPG) levels and improved capacity to release oxygen to tissue. The mixture of baboon donor-recipient red blood cells in the circula...

journal_title：Transfusion

authors： Zaroulis CG,Pivacek LE,Lowrie GB,Valeri CR

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Blood conservation strategies have been shown to be effective in decreasing red blood cell (RBC) utilization in specific patient groups. However, few data exist describing the extent of RBC transfusion reduction or their impact on transfusion practice and mortality in a diverse inpatient population. STUDY D...

journal_title：Transfusion

authors： Roubinian NH,Escobar GJ,Liu V,Swain BE,Gardner MN,Kipnis P,Triulzi DJ,Gottschall JL,Wu Y,Carson JL,Kleinman SH,Murphy EL,NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III).

更新日期：2014-10-01 00:00:00

abstract：:The ability to store platelets beyond 24 hours requires a functionally closed system. This study tested the ability of a cell separator bowl seal system to resist penetration of microbial contamination under normal running conditions and under extreme environmental stress. Three test organisms, Micrococcus luteus, Ser...

journal_title：Transfusion

authors： Jacobson MS,Kevy SV,Thorne GM,Goldmann DA,Blasetti L,Smith JW,Schaefer H

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:A quality monitoring program (QMP) for platelet concentrates (PCs) was implemented at Canadian Blood Services (CBS) to improve standards and to better understand platelet (PLT) products by supplementing routine quality control (QC). STUDY DESIGN AND METHODS:Annual surveys of PCs from CBS production sites we...

journal_title：Transfusion

authors： Levin E,Jenkins C,Culibrk B,Gyöngyössy-Issa MI,Serrano K,Devine DV

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Patients with severe combined immunodeficiency (SCID) treated with allogeneic bone marrow transplantation often receive a milder conditioning regimen than patients who undergo transplantation for hematologic malignancy, and they regularly retain circulating white cells of host origin. The origin of circulati...

journal_title：Transfusion

authors： Brady KA,Cowan MJ,Leavitt AD

更新日期：1996-04-01 00:00:00