Abstract:
:This study presents a combined small animal holding fixture system, termed a 'bridge capsule', which provides for small animal re-fixation with positional reproducibility. This system comprises separate holding fixtures for the head and lower body and a connecting part to a gas anesthesia system. A mouse is fixed in place by the combination of a head fixture with a movable part made from polyacetal resin, a lower body fixture made from vinyl-silicone and a holder for the legs and tail. For re-fixation, a similar posture could be maintained by the same holding fixtures and a constant distance between the head and lower body fixtures is maintained. Artifacts caused by the bridge capsule system were not observed on magnetic resonance (MRI) and positron emission tomography (PET) images. The average position differences of the spinal column and the iliac body before and after re-fixation for the same modality were approximately 1.1 mm. The difference between the MRI and PET images was approximately 1.8 mm for the lower body fixture after image registration using fiducial markers. This system would be useful for longitudinal, repeated and multimodal imaging experiments requiring similar animal postures.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Kokuryo D,Kimura Y,Obata T,Yamaya T,Kawamura K,Zhang MR,Kanno I,Aoki Idoi
10.1088/0031-9155/55/14/011subject
Has Abstractpub_date
2010-07-21 00:00:00pages
4119-30issue
14eissn
0031-9155issn
1361-6560pii
S0031-9155(10)53843-0journal_volume
55pub_type
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