Abstract:
BACKGROUND AND OBJECTIVE:There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the coronavirus disease 2019 (COVID-19) pandemic. The number of registered trials related to COVID-19 is increasing by the day. The objective of this study was to describe the characteristics of the currently registered interventional clinical trials related to COVID-19. METHODS:We searched the World Health Organization's International Clinical Trials Registry Platform on May 15th, 2020. We included any entry that is related to COVID-19. We abstracted and then descriptively analyzed the following characteristics of the registered trials: study design, status, phase, primary endpoints, experimental interventions, and geographic location among other qualifiers. RESULTS:We identified 1,308 eligible registered trials. Most trials were registered with ClinicalTrials.gov (n = 703; 53.7%) and the Chinese Clinical Trial Registry (n = 291; 22.2%). The number of participants to be enrolled across these trials was 734,657, with a median of 110 participants per trial. The most commonly studied intervention category was pharmacologic (n = 763; 58.3%), with antiparasitic medications being the most common subcategory. Although over half of the trials were already recruiting, we identified published peer-reviewed results for only 8 of those trials. CONCLUSION:There is a relatively large number of registered trials but with very few results published so far. Although our findings suggest an appropriate initial response by the research community, the real challenge will be to get these trials completed, published, and translated into practice and policy.
journal_name
J Clin Epidemioljournal_title
Journal of clinical epidemiologyauthors
Nasrallah AA,Farran SH,Nasrallah ZA,Chahrour MA,Salhab HA,Fares MY,Khachfe HH,Akl EAdoi
10.1016/j.jclinepi.2020.06.005subject
Has Abstractpub_date
2020-09-01 00:00:00pages
170-178eissn
0895-4356issn
1878-5921pii
S0895-4356(20)30441-8journal_volume
125pub_type
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章,评审
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doi:10.1016/0895-4356(93)90052-3
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/j.jclinepi.2016.01.028
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journal_title:Journal of clinical epidemiology
pub_type: 传,历史文章,杂志文章
doi:10.1016/s0895-4356(96)00294-6
更新日期:1996-12-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/j.jclinepi.2018.07.007
更新日期:2018-11-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/0895-4356(93)90073-a
更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0895-4356(95)00014-u
更新日期:1995-09-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/j.jclinepi.2018.11.023
更新日期:2019-03-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/s0895-4356(97)00130-3
更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/s0895-4356(96)00421-0
更新日期:1997-04-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
doi:10.1016/j.jclinepi.2004.08.009
更新日期:2005-04-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章
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journal_title:Journal of clinical epidemiology
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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更新日期:2016-11-01 00:00:00