Cellular therapies for graft-versus-host disease: a tale of tissue repair and tolerance.

abstract：:Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow. Unlike autoimmune hemolytic anemia, which is characterized by an increased number of reticulocytes, positive Coo...

journal_title：Blood

authors： Ghazal H

更新日期：2002-02-01 00:00:00

abstract：:The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Rema...

journal_title：Blood

authors： Yao H,Goldman DC,Nechiporuk T,Kawane S,McWeeney SK,Tyner JW,Fan G,Kerenyi MA,Orkin SH,Fleming WH,Mandel G

更新日期：2014-05-15 00:00:00

abstract：:Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...

journal_title：Blood

authors： Rowley M,Liu P,Van Ness B

更新日期：2000-11-01 00:00:00

abstract：:The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, ...

journal_title：Blood

authors： Peter K,Schwarz M,Ylänne J,Kohler B,Moser M,Nordt T,Salbach P,Kübler W,Bode C

更新日期：1998-11-01 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:Multiple mechanisms operate to ensure T-cell tolerance toward self-antigens. Three main processes have been described: clonal deletion, anergy, and deviation to CD4(+) regulatory T cells (Tregs) that suppress autoreactive T cells that have escaped the first 2 mechanisms. Although it is accepted that dendritic cells (D...

journal_title：Blood

authors： Morlacchi S,Soldani C,Viola A,Sarukhan A

更新日期：2011-07-28 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:The bone marrow (BM) microenvironment consists of extracellular-matrix and the cellular compartment including immune cells. Multiple myeloma (MM) cell and BM accessory cell interaction promotes MM survival via both cell-cell contact and cytokines. Immunomodulatory agents (IMiDs) target not only MM cells, but also MM c...

journal_title：Blood

authors： Görgün G,Calabrese E,Soydan E,Hideshima T,Perrone G,Bandi M,Cirstea D,Santo L,Hu Y,Tai YT,Nahar S,Mimura N,Fabre C,Raje N,Munshi N,Richardson P,Anderson KC

更新日期：2010-10-28 00:00:00

abstract：:We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

journal_title：Blood

authors： Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

更新日期：1993-07-01 00:00:00

abstract：:Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...

journal_title：Blood

authors： Merkenschlager J,Eksmond U,Danelli L,Attig J,Young GR,Nowosad C,Tolar P,Kassiotis G

更新日期：2019-03-07 00:00:00

abstract：:The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits. Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxa...

journal_title：Blood

authors： Sandau KB,Fandrey J,Brüne B

更新日期：2001-02-15 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:Regulatory CD25(+)CD4+ T cells (Treg cells) are a central element of peripheral tolerance. Little is known, however, about phenotypic and functional characteristics of these cells with regard to memory. In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells. Simila...

journal_title：Blood

authors： Kleinewietfeld M,Puentes F,Borsellino G,Battistini L,Rötzschke O,Falk K

更新日期：2005-04-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages engaged in recycling of red cells were depleted from the tissues of Hmox1...

journal_title：Blood

authors： Kovtunovych G,Ghosh MC,Ollivierre W,Weitzel RP,Eckhaus MA,Tisdale JF,Yachie A,Rouault TA

更新日期：2014-08-28 00:00:00

abstract：:Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modification with lentiviral vectors (LVs), thus requiring high doses or repe...

journal_title：Blood

authors： Ozog S,Timberlake ND,Hermann K,Garijo O,Haworth KG,Shi G,Glinkerman CM,Schefter LE,D'Souza S,Simpson E,Sghia-Hughes G,Carillo RR,Boger DL,Kiem HP,Slukvin I,Ryu BY,Sorrentino BP,Adair JE,Snyder SA,Compton AA,Torbet

更新日期：2019-10-17 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:Stimulated neutrophils show ionic fluxes that may function as "transducers" between stimuli and effector functions. Using fluorescent probes, patterns of membrane-associated calcium (chlortetracycline, CTC) and membrane potential (3-3'-dipentyloxacarbocyanine, di-O-C5 (3)) in single living human neutrophils were obser...

journal_title：Blood

authors： Sullivan GW,Donowitz GR,Sullivan JA,Mandell GL

更新日期：1984-12-01 00:00:00

abstract：:The enhancement of in vitro human hematopoiesis by the addition of a noncytotoxic monoclonal antibody, 9.1C3, is described. Enhancement of all aspects of in vitro hematopoiesis was observed on addition of 9.1C3 antibody to cultures of mononuclear cells from normal bone marrow, cord blood, and peripheral blood from bet...

journal_title：Blood

authors： Kannourakis G,Johnson GR,Begley CG,Werkmeister JA,Burns GF

更新日期：1988-10-01 00:00:00

abstract：:Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer ...

journal_title：Blood

authors： Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR

更新日期：2008-03-01 00:00:00

abstract：:An unbalanced translocation der(1;7)(q10; p10) is a nonrandom chromosomal aberration commonly observed in myelodysplastic syndrome and acute myeloid leukemia. We molecularly analyzed the breakpoints of der(1;7)(q10;p10) by quantitative fluorescent in situ hybridization (FISH) analyses using centromeric satellite DNAs ...

journal_title：Blood

authors： Wang L,Ogawa S,Hangaishi A,Qiao Y,Hosoya N,Nanya Y,Ohyashiki K,Mizoguchi H,Hirai H

更新日期：2003-10-01 00:00:00

abstract：:Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies described herein examine the role in hematopoiesis of Osteopontin (Opn), a multidomain, phosphorylated glycoprotein, synthesized by ost...

journal_title：Blood

authors： Nilsson SK,Johnston HM,Whitty GA,Williams B,Webb RJ,Denhardt DT,Bertoncello I,Bendall LJ,Simmons PJ,Haylock DN

更新日期：2005-08-15 00:00:00

abstract：:To further unravel the molecular pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), we performed high-resolution array comparative genomic hybridization on diagnostic specimens from 47 children with T-ALL and identified monoallelic or biallelic LEF1 microdeletions in 11% (5 of 47) of these primary samples. A...

journal_title：Blood

authors： Gutierrez A,Sanda T,Ma W,Zhang J,Grebliunaite R,Dahlberg S,Neuberg D,Protopopov A,Winter SS,Larson RS,Borowitz MJ,Silverman LB,Chin L,Hunger SP,Jamieson C,Sallan SE,Look AT

更新日期：2010-04-08 00:00:00

abstract：:Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activat...

journal_title：Blood

authors： Hermann E,Truyens C,Alonso-Vega C,Even J,Rodriguez P,Berthe A,Gonzalez-Merino E,Torrico F,Carlier Y

更新日期：2002-09-15 00:00:00

abstract：:The novel immunosuppressant FTY720 activates sphingosine 1-phosphate receptors (S1PRs) that affect responsiveness of lymphocytes to chemokines such as stromal cell-derived factor 1 (SDF-1), resulting in increased lymphocyte homing to secondary lymphoid organs. Since SDF-1 and its receptor CXCR4 are also involved in bo...

journal_title：Blood

authors： Kimura T,Boehmler AM,Seitz G,Kuçi S,Wiesner T,Brinkmann V,Kanz L,Möhle R

更新日期：2004-06-15 00:00:00

abstract：:Retention of lipoproteins within the vasculature is a central event in the pathogenesis of atherosclerosis. However, the signals that mediate this process are only partially understood. Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutroph...

journal_title：Blood

authors： Bdeir K,Cane W,Canziani G,Chaiken I,Weisel J,Koschinsky ML,Lawn RM,Bannerman PG,Sachais BS,Kuo A,Hancock MA,Tomaszewski J,Raghunath PN,Ganz T,Higazi AA,Cines DB

更新日期：1999-09-15 00:00:00

abstract：:We analyzed the expression of plasma glutathione peroxidase (GSHPx-P) messenger RNA (mRNA) in mouse, rat, and human tissues, using a human GSHPx-P cDNA clone as the probe. Unlike the classical cellular glutathione peroxidase (GSHPx-1), GSHPx-P expression appears to be tissue-specific. In the mouse and rat, kidney expr...

journal_title：Blood

authors： Chu FF,Esworthy RS,Doroshow JH,Doan K,Liu XF

更新日期：1992-06-15 00:00:00

abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

journal_title：Blood

authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

更新日期：2009-06-04 00:00:00

abstract：:A 53-yr-old man sequentially developed aplastic anemia from phenytoin and carbamazepine. Both compounds undergo metabolism to potentially toxic arene oxide intermediates. We tested the hypothesis that the patient's adverse reactions were due to a defect in detoxification of such metabolites by challenging his peripher...

journal_title：Blood

authors： Gerson WT,Fine DG,Spielberg SP,Sensenbrenner LL

更新日期：1983-05-01 00:00:00

abstract：:The monoclonal antibody STRO-1 identifies clonogenic bone marrow stromal cell progenitors (fibroblast colony-forming units [CFU-F]) in adult human bone marrow. These STRO-1+ CFU-F have previously been shown to give rise to cells with the phenotype of fibroblasts, adipocytes, and smooth muscle cells. In this study, the...

journal_title：Blood

authors： Gronthos S,Graves SE,Ohta S,Simmons PJ

更新日期：1994-12-15 00:00:00