Abstract:
:Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in an otherwise healthy newborn. The most serious complication is intracranial hemorrhage, which can occur either in the fetus or the newborn. Despite the known serious sequelae, both antenatal management and neonatal treatment modalities are plagued by the lack of gold standard evidence to appropriately direct therapy. Maternal, risk-based therapeutic approaches range from invasive protocols to relatively benign noninvasive strategies to avoid serious procedural complications. Intravenous immunoglobulin (IVIG) with or without steroids and fetal blood sampling constitute the mainstay of antenatal management. Neonatal interventions principally focus on the use of antigen-negative compatible or random donor platelets and IVIG. While awaiting the results of controlled trials, each institution must develop a standardized, collaborative, multidisciplinary approach to the screening, diagnostic evaluation, and management of unexpected and anticipated NAIT based on experience, product availability, and emerging scientific data.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Symington A,Paes Bdoi
10.1055/s-0030-1263296subject
Has Abstractpub_date
2011-02-01 00:00:00pages
137-44issue
2eissn
0735-1631issn
1098-8785journal_volume
28pub_type
杂志文章,评审abstract:OBJECTIVE: Neuromuscular re-education (NMRE) therapy including bracing, containment, facilitation techniques, joint compression, weight (WT) bearing, and myofascial release has been shown to improve neurodevelopmental maturation in premature infants. This study aimed to examine the association of NMRE with growth param...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1716492
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVE:To evaluate the association between adequacy of prenatal care utilization and risk of fetal and neonatal mortality and adverse outcomes. METHODS:We conducted a population-based cohort study using the Center for Disease Control and Prevention's Linked Birth-Infant Death and Fetal Death data on all deliveries ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1316439
更新日期:2012-11-01 00:00:00
abstract::The accuracy of eight ultrasonic fetal weight formulas were analyzed in 1099 fetuses who underwent real-time ultrasound examination within 72 hours prior to delivery. Shepard's formula was most consistently found to give the lowest systematic and random errors throughout all weight categories, though Deter's formula h...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999944
更新日期:1985-07-01 00:00:00
abstract::Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the on...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2006-934093
更新日期:2006-04-01 00:00:00
abstract::Although values for cardiac output in the newborn infant have been reported previously, the methods utilized have been invasive. To assess if cardiac output could be determined noninvasively in the neonate, we measured mean ascending aortic blood flow velocity (VAo) in well newborns using a portable 5MHz, range gated,...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999991
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Postpartum higher-dose oxytocin (80 U) compared with lower dose (10 U) given in 500 mL over 1 hour does not decrease postpartum hemorrhage (PPH) requiring treatment, but reduces the risk of hematocrit decline ≥ 6% among women delivering vaginally. Our objective was to evaluate whether the duration of administ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1370347
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE: Delayed maturation of auditory brainstem pathway in neonates admitted to the neonatal intensive care unit (NICU) may lead to misdiagnosis of children with normal peripheral hearing and inappropriate use of amplification devices. The aim of this study is to determine the pattern of auditory brain stem respons...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1709467
更新日期:2020-04-10 00:00:00
abstract:OBJECTIVE:To develop a model to predict cesarean-associated red blood cell transfusion. STUDY DESIGN:Secondary analysis of all cesarean deliveries in the Maternal-Fetal Medicine Units Network Cesarean Registry. Using a split-sample technique, the derivation group was used to identify associated factors and build predi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1678604
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To determine the associations of measured protein, energy, and protein-to-energy (PER) intakes with body composition in human milk (HM)-fed preterm infants. STUDY DESIGN:Neonates born at < 33 gestational weeks were eligible. Standard fortification method with modular supplements was used and the HM compositi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1626717
更新日期:2018-07-01 00:00:00
abstract::We evaluated if maternal demographic and ultrasound parameters predict perinatal mortality in preterm intrauterine growth restriction (IUGR). Retrospective cohort study of preterm IUGR (delivery gestational age <35 weeks and birth weight <10th percentile for gestation). We excluded twins and fetuses with aneuploidy, i...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1223284
更新日期:2009-11-01 00:00:00
abstract::The use of transabdominal vibroacoustic stimulation has been shown to improve the efficiency of antepartum fetal surveillance. The ability of the fetus to habituate to such a stimulus has also been suggested as a means of assessing the function of the central nervous system. The purpose of this blinded prospective inv...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999420
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE: To determine reference values for myocardial volume of the fetal heart using three-dimensional ultrasound with spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL) and to assess their applicability in women with pregestational diabetes. STUDY DESIGN: This retrospective c...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-3400983
更新日期:2019-12-13 00:00:00
abstract::Background Late-onset sepsis (LOS) in very low-birth-weight (VLBW) infants is associated with significant morbidity and mortality. Objectives To determine the incidence of LOS workup, association, and predictive value of clinical indicators leading to culture-positive versus culture-negative sepsis workup. Methods All...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1579648
更新日期:2016-07-01 00:00:00
abstract::Infants born from mothers with antiphospholipid antibody (aPL) -positive autoimmune disease were prospectively evaluated for anticardiolipin and anti-beta2 glycoprotein I antibodies (group 1) and for growth and neurological development. The results were compared with those obtained from two age-matched control groups ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2006-939533
更新日期:2006-05-01 00:00:00
abstract::The purpose of this study was to establish normative reference values for serum unconjugated estriol (E3) concentrations in insulin-dependent diabetic pregnancy. There were 1973 samples analyzed in 63 diabetic pregnancies not complicated by fetal distress and/or neonatal asphyxia. These samples were compared with 867 ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999718
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE: Semiquantitative lung ultrasound improves the timeliness of surfactant replacement, but its financial consequences are unknown. We aim to investigate if the ultrasound-guided surfactant administration influences the general costs of surfactant therapy for preterm neonates affected by respiratory distress syn...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1715821
更新日期:2020-08-20 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1552934
更新日期:2015-11-01 00:00:00
abstract::Introduction Our aim was to survey clinicians to assess awareness and utilization of the NICHD Neonatal Research Network outcomes estimator, which allows clinicians to use multiple factors to better estimate the likelihood that intensive care will benefit the delivered neonate. Study Design The survey tool included a ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1582396
更新日期:2016-08-01 00:00:00
abstract::As new information about coronavirus disease 2019 (COVID-19) is rapidly discovered, clinicians are better equipped to make informed decisions for their patients. While current research suggests COVID-19 viral antigen is not found in vaginal secretions, its detectability in the female lower genital tract may have clini...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1713665
更新日期:2020-09-01 00:00:00
abstract::Intrapartum fetal scalp sampling for platelet counts in maternal autoimmune thrombocytopenia has been advocated for determining route of delivery. We report a case in which two coagulated scalp samples were believed to indicate a normal fetal platelet count. As a result, vaginal delivery of a severely thrombocytopenic...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999401
更新日期:1991-09-01 00:00:00
abstract::Seven sociodemographic and behavioral factors that may explain the increased risk of preterm deliveries among black women were examined using data from a national sample of 5823 married mothers who responded to the 1980 National Natality Survey (NNS) Questionnaire. There was a twofold increase in the rate of preterm d...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999412
更新日期:1991-09-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994402
更新日期:1995-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999655
更新日期:1988-01-01 00:00:00
abstract::We report about two newborns with sudden onset of inability of mechanical ventilation due to transient chest wall rigidity after fentanyl i.v. bolus of 2 and 4 microg/kg, respectively, resulting in severe hypoxemia and secondary bradycardia. A third case developed a rigidity of the tongue after fentanyl bolus, which c...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-7289
更新日期:2000-01-01 00:00:00
abstract::We evaluated the efficacy, safety, and biological mechanisms of digoxin immune Fab (DIF) treatment of severe preeclampsia. Fifty-one severe preeclamptic patients were randomized in double-blind fashion to DIF ( N = 24) or placebo ( N = 27) for 48 hours. Primary outcomes were change in creatinine clearance (CrCl) at 24...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0030-1249762
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:We aimed to compare the rates of "surfactant treated respiratory disease" and other neonatal morbidities among moderately preterm (MPT) infants exposed to no, partial, or a complete course of antenatal corticosteroids (ANS). STUDY DESIGN:This observational cohort study evaluated MPT infants (290/7-336/7 week...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
doi:10.1055/s-0038-1642059
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation. MATERIALS AND METHODS:This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (S...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667029
更新日期:2019-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
abstract::Although cesarean section is one of the most ancient surgical procedures, the origin of its name remains obscure. The term, however, did not originate because of the birth of the Roman Emperor Julius Caesar through this route. In fact, historians are certain that Julius Caesar was not delivered by the dangerous cesare...
journal_title:American journal of perinatology
pub_type: 历史文章,杂志文章
doi:10.1055/s-2007-986693
更新日期:2007-11-01 00:00:00
abstract::We present a case of congenital parvovirus B19 infection in a term neonate manifested with isolated massive hydrothorax and mild anemia. Parvovirus B19 DNA was detected in maternal and neonatal blood as well as in pleural fluid despite lack of suggestive serology. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1085621
更新日期:2008-10-01 00:00:00