Abstract:
BACKGROUND:Metabolic syndrome (MS) and diabetes mellitus (DM) are risk factors for cardiovascular diseases in general population. However, there was a paucity of studies investigating their impact in primary glomerular diseases (PGD). HYPOTHESIS:MS and concomitant DM are associated with higher risk of cardiovascular comorbidity in PGD. METHODS:In a retrospective observational design, we analyzed 3622 hospitalized adult PGD patients and compared the prevalence of cardiovascular comorbidity in non-MS, MS with and without DM. Risk factors for cardiovascular comorbidity were identified using univariate and multivariate logistic regression. RESULTS:Among 3622 PGD patients, 308 (8.5%) cases accompanied with MS, including 180 (5.0%) patients with DM and 128 (3.5%) without DM. One hundred and sixty four (4.5%) cases coexisted with cardiovascular comorbidity. Patients with MS and concomitant DM exhibited a higher prevalence of cardiovascular comorbidity than those without MS stratified by estimated glomerular filtration rate and pathological types. Logistic regression showed that MS and concomitant DM (OR: 2.496, 95% CI: 1.600-3.894, P < .001), older age (OR: 1.060, 95% CI: 1.047-1.074, P < .001), male (OR: 1.536, 95% CI: 1.072-2.200, P = .019), higher level of serum ti (OR: 1.002, 95% CI: 1.001-1.003, P < .001), hyperuricemia (OR: 1.901, 95% CI: 1.327-2.725, P < .001), idiopathic membranous nephropathy (OR: 2.874, 95% CI: 1.244-6.640, P < .001) and focal segmental glomerulosclerosis (OR: 2.906, 95% CI: 1.147-7.358, P < .001) were independently associated with a higher risk for cardiovascular comorbidity. CONCLUSIONS:In PGD patients, MS and concomitant DM are associated with an increased risk for cardiovascular comorbidity. More evidence for the causal link between MS/DM and cardiovascular outcomes is needed to be clarified.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Xie Z,Li Z,Dong W,Chen Y,Li R,Wu Y,Lin T,Tao Y,Liang H,Wang W,Liu S,Ye Z,Shi W,Liang Xdoi
10.1002/clc.23388subject
Has Abstractpub_date
2020-09-01 00:00:00pages
949-956issue
9eissn
0160-9289issn
1932-8737journal_volume
43pub_type
杂志文章abstract:BACKGROUND:The impact of permanent pacemaker (PPM) on long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) has not been studied. HYPOTHESIS:PPM may increase heart failure (HF) burden on patients undergoing PCI. METHODS:We recruited consecutive patients undergoing PCI and carried...
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更新日期:2017-04-01 00:00:00
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journal_title:Clinical cardiology
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pub_type: 杂志文章,多中心研究
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更新日期:2015-02-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20885
更新日期:2011-06-01 00:00:00
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更新日期:1999-10-01 00:00:00
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