Abstract:
BACKGROUND:Primary percutaneous coronary intervention (PCI) is the most common method of reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) in the United States. The intersection between processes of care and performance measures such as door-to-balloon (D2B) times and clinical trials evaluating novel therapies for STEMI has not been fully investigated. HYPOTHESIS:Processes of STEMI care, incorporating clinical trial enrollment and randomization, in patients undergoing reperfusion with primary PCI in the Counterpulsation Reduces Infarct Size Pre-Percutaneous Coronary Intervention Acute Myocardial Infarction trial (CRISP-AMI) will conform to current standards of care. METHODS:Patients enrolled in CRISP-AMI were included in the current analysis. Processes of care during reperfusion were recorded prospectively and compared between groups. RESULTS:A total of 337 patients with anterior STEMI without cardiogenic shock were randomized in CRISP-AMI. Complete processes-of-care data were available for 303 patients (89.9%). In this cohort, 68.0% of patients underwent reperfusion within 90 minutes of hospital contact, and the median D2B time was 71 minutes. Time from hospital contact to informed consent was significantly different across different regions (North America, 45 minutes; India, 35 minutes; Europe, 20 minutes). CONCLUSIONS:In CRISP-AMI, reperfusion was accomplished in a timely fashion while incorporating informed consent and randomization among patients with anterior myocardial infarction. Further study of patients' comprehension and preferences during the informed-consent process in STEMI patients is warranted so that innovative drugs and devices can be safely and ethically tested.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Jones WS,Clare RM,Chiswell K,Perera D,French JK,Kumar AS,Blaxill J,Pijls N,Mills J,Ohman EM,Patel MRdoi
10.1002/clc.22349subject
Has Abstractpub_date
2015-01-01 00:00:00pages
25-31issue
1eissn
0160-9289issn
1932-8737journal_volume
38pub_type
杂志文章,随机对照试验abstract:BACKGROUND AND HYPOTHESIS:Genetic influence on development of athlete's heart is uncertain. This study investigated whether angiotensin-converting enzyme (ACE) gene polymorphism influenced development of athlete's heart. METHODS:Forty-three participants in a 100-km ultramarathon were classified on the basis of ACE gen...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960230814
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Takotsubo cardiomyopathy (TCM) is characterized by systolic ballooning of the left ventricular apex. It is triggered by emotional or physical stress, but the exact mechanism through which stress leads to TCM is not known. HYPOTHESIS:Coronary microvessel apoptosis is the missing link between stress and TCM. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20777
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The impact of permanent pacemaker (PPM) on long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) has not been studied. HYPOTHESIS:PPM may increase heart failure (HF) burden on patients undergoing PCI. METHODS:We recruited consecutive patients undergoing PCI and carried...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22645
更新日期:2017-04-01 00:00:00
abstract::Several investigators have documented the successful use of oral sustained-release theophylline in treating symptomatic bradycardia and sick sinus syndrome. This paper reports a case of chronotropic incompetence in which specific exercise indices, including the chronotropic response index, were used to measure the the...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,评审
doi:10.1002/clc.4960231019
更新日期:2000-10-01 00:00:00
abstract::Aspirin is integral in the primary and secondary prevention of coronary artery disease and acute coronary syndrome. Given the high clinical importance of aspirin in the management of coronary artery disease, much attention has been directed towards the concept of "aspirin resistance." Unfortunately, the term aspirin r...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22031
更新日期:2012-11-01 00:00:00
abstract::The realization that cardiovascular morbidity and mortality increases in patients with mild elevation of either systolic or diastolic blood pressure has led to a consideration to treat millions of patients with mild diastolic or isolated systolic hypertension. The cost of administering a successful antihypertensive tr...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960060101
更新日期:1983-01-01 00:00:00
abstract::The use of neuroleptanalgesia in acute myocardial infarction offers the possibility of reducing pain and emotional stress. The influence of such treatment on hemodynamic parameters (heart rate, cardiac output, stroke volume, peripheral resistance, systemic blood pressure, and pulmonary pressure) and on the plasma leve...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040505
更新日期:1981-09-01 00:00:00
abstract::In order to study left ventricular diastolic function, digitized M-mode echocardiograms of the free wall endocardium were analyzed. A population of 117 healthy individuals was compared with a group of 22 patients with myocardial hypertrophy due to aortic stenosis (AS), and a group of 21 with hypertrophic cardiomyopath...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070604
更新日期:1984-06-01 00:00:00
abstract::Most series of patients with ventricular tachycardia (VT) of right bundle-branch block (RBBB)-left axis deviation (LAD) morphology include young individuals with no overt evidence of structural heart disease. In the present report, the clinical and electrophysiologic findings in two patients with verapamil-responsive ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150617
更新日期:1992-06-01 00:00:00
abstract::The importance of a history of angina pectoris on long-term timolol treatment after myocardial infarction was studied with respect to mortality and reinfarction. The analyses were performed retrospectively using cohorts from the Norwegian timolol multicenter study. In patients without angina pectoris prior to the infa...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960080205
更新日期:1985-02-01 00:00:00
abstract::Congestive heart failure (CHF) is a common manifestation of hypertension, coronary artery disease, and dilated cardiomyopathy. The Framingham study showed that the incidence of CHF increases twofold with each decade of age. The presence of CHF increases the age-adjusted death rate 5.5-fold for women and 8-fold for men...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
abstract::Coronary collateral perfusion to the completely obstructed coronary artery was evaluated by coronary cineangiography in 32 patients. In 13 patients, there was neither history of severe chest pain of longer than 30-min duration nor electrocardiographic evidence of a transmural myocardial infarction (Group I). Among pat...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100705
更新日期:1987-07-01 00:00:00
abstract::A total of 1150 consecutive patients (1052 males and 98 females; age 51.2 +/- 10.1 years) with suspected coronary artery disease (Group I) were subjected to fluoroscopy for detection of coronary artery calcification (CAC) and coronary angiography. Another group (Group II) of 120 patients (95 males and 25 females; age ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960110705
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MS) and diabetes mellitus (DM) are risk factors for cardiovascular diseases in general population. However, there was a paucity of studies investigating their impact in primary glomerular diseases (PGD). HYPOTHESIS:MS and concomitant DM are associated with higher risk of cardiovascular c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23388
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Oxidized low-density lipoprotein (oxLDL) not only plays an important role in plaque formation, but also impairs the endothelium-dependent relaxation. Constrictive remodeling rather than intimal hyperplasia mainly contributes to restenosis after balloon angioplasty. Probucol (powerful antioxidant) reduced res...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260107
更新日期:2003-01-01 00:00:00
abstract::This study was conducted to determine the long-term effects of percutaneous transluminal coronary angioplasty (PTCA) on the incidence of myocardial infarction, survival, and relief of symptoms. A total of 124 patients were included in the study and were followed for 16 to 25 months. The success rate of PTCA was 91.2% ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120805
更新日期:1989-08-01 00:00:00
abstract::A 56-year-old male with atrial fibrillation developed rapid ventricular response up to 200 beats/min or more in the postoperative stage of emergency aortocoronary bypass surgery. Resuscitation for cardiac arrest triggered this rapid ventricular rate. The idea that retrograde conduction into atrioventricular node may p...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100412
更新日期:1987-04-01 00:00:00
abstract::Signal-averaged electrocardiograms were obtained in 53 consecutive patients with a first acute myocardial infarction (AMI) who survived the first 10 days of hospitalization. The recording was performed twice, at Day 1 and at Day 10 of hospitalization, in patients without bundle-branch block and who did not receive ant...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960131005
更新日期:1990-10-01 00:00:00
abstract::The purpose of this study was to determine whether computerized ST-segment monitoring previous to percutaneous transluminal coronary angioplasty (PTCA) and after performance of this procedure may be useful to discern a pattern of recurrent angina. For this purpose, we analyzed 57 patients (11 women and 46 men, mean ag...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170806
更新日期:1994-08-01 00:00:00
abstract::Noninvasive determination of left-side intracardiac pressures is of clinical importance in many cardiac diseases. To test the reliability and accuracy of left-side intracardiac pressure measurements by continuous-wave Doppler echocardiography, using left-side valvular regurgitations, 47 patients with mitral regurgitat...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960161206
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Due to chronic inflammatory status, rheumatoid arthritis (RA) patients are exposed to changes in left ventricular (LV) geometry and function. We assessed prevalence, factors associated with, and prognostic role of concentric LV geometry and systolic dysfunction (LVSD) detected by echocardiography in a large ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22926
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The Reduction in ENdpoints with the Angiotensin Antagonist Losartan (RENAAL) study reported that losartan delayed the progression of renal disease in patients with type 2 diabetes and nephropathy. Diabetic or renally impaired patients are at high cardiovascular risk, a risk potentially increased in patients ...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960280307
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Electromechanical (EM) coupling heterogeneity is significant in long QT syndrome (LQTS), particularly in symptomatic patients; EM window (EMW) has been proposed as an indicator of interaction and a better predictor of arrhythmia than QTc. HYPOTHESIS:To investigate the dynamic response of EMW to exercise in ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23132
更新日期:2019-02-01 00:00:00
abstract::Isolated tricuspid insufficiency (TI) is relatively uncommon and mostly of traumatic origin. We report clinical noninvasive and invasive findings and surgical results in 5 cases. All patients had complete clinical, noninvasive and invasive studies including right and left catheterization, and coronary angiographies in...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070509
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Acute coronary syndromes (ACS) are characterized by activation of systemic and local inflammatory mediators. The interrelation between these soluble inflammatory markers and their association with markers of myocardial necrosis have not been extensively studied. HYPOTHESIS:The study was undertaken to evalua...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960280405
更新日期:2005-04-01 00:00:00
abstract::The cardiokymograph, a relatively new noninvasive device capable of recording anterior left ventricular segmental wall motion, was used to evaluate the frequency and type of wall motion abnormalities in 25 normal patients and in 109 patients with ischemic heart disease. Of the 25 patients with normal coronary arteries...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960030605
更新日期:1980-12-01 00:00:00
abstract::Balancing the benefits, risks, and cost of thrombolytic treatment is a complex issue which depends considerably upon the variable threat of the thrombus to organ physiology and patient survival. For example, after deep vein thrombosis (DVT), the major risk is long-term disability due to the postphlebitic syndrome, whi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Females with Ullrich-Turner syndrome (UTS) have typical clinical features such as short stature, ovarian failure, visible dysmorphic stigmata, and abnormalities in different organs such as kidney or heart. HYPOTHESIS:The aim of the present study was to analyze the distribution, prevalence, and relative risk...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960280209
更新日期:2005-02-01 00:00:00
abstract::The aim of this study was to assess whether drinking social amounts of alcohol impairs myocardial contractility in normal humans. To that end, 17 healthy volunteers performed isometric handgrip exercise before and 60 minutes after an intake of 1 g/kg body weight of ethanol within 60 minutes. Left ventricular M-mode ec...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060302
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:In patients with stable angina pectoris, eccentric stenoses have a greater potential for dynamic changes of caliber in response to vasoactive stimuli than concentric lesions. It is not known whether in patients with coronary artery spasm the degree of coronary vasoconstriction differs in eccen...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960210907
更新日期:1998-09-01 00:00:00