The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: observations from the CRISP-AMI trial.


BACKGROUND:Primary percutaneous coronary intervention (PCI) is the most common method of reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) in the United States. The intersection between processes of care and performance measures such as door-to-balloon (D2B) times and clinical trials evaluating novel therapies for STEMI has not been fully investigated. HYPOTHESIS:Processes of STEMI care, incorporating clinical trial enrollment and randomization, in patients undergoing reperfusion with primary PCI in the Counterpulsation Reduces Infarct Size Pre-Percutaneous Coronary Intervention Acute Myocardial Infarction trial (CRISP-AMI) will conform to current standards of care. METHODS:Patients enrolled in CRISP-AMI were included in the current analysis. Processes of care during reperfusion were recorded prospectively and compared between groups. RESULTS:A total of 337 patients with anterior STEMI without cardiogenic shock were randomized in CRISP-AMI. Complete processes-of-care data were available for 303 patients (89.9%). In this cohort, 68.0% of patients underwent reperfusion within 90 minutes of hospital contact, and the median D2B time was 71 minutes. Time from hospital contact to informed consent was significantly different across different regions (North America, 45 minutes; India, 35 minutes; Europe, 20 minutes). CONCLUSIONS:In CRISP-AMI, reperfusion was accomplished in a timely fashion while incorporating informed consent and randomization among patients with anterior myocardial infarction. Further study of patients' comprehension and preferences during the informed-consent process in STEMI patients is warranted so that innovative drugs and devices can be safely and ethically tested.


Clin Cardiol


Clinical cardiology


Jones WS,Clare RM,Chiswell K,Perera D,French JK,Kumar AS,Blaxill J,Pijls N,Mills J,Ohman EM,Patel MR




Has Abstract


2015-01-01 00:00:00












  • Antiarrhythmic and proarrhythmic properties of diazepam demonstrated by electrophysiological study in humans.

    abstract::We evaluated the electrophysiological parameters before and after the intravenous infusion of diazepam (0.2 mg/kg) in 20 cardiac patients to investigate the drug's antiarrhythmic effect. Diazepam did not significantly change the arterial pressure. After the intravenous infusion of diazepam, the sinus cycle length sign...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Kumagai K,Yamanouchi Y,Matsuo K,Tashiro N,Hiroki T,Arakawa K

    更新日期:1991-05-01 00:00:00

  • Heparin-induced thrombocytopenia associated with pulmonary embolism.

    abstract::Type II heparin-induced thrombocytopenia (HIT) is a potentially severe adverse effect of heparin treatment triggered by an immune response. Although most cases occur in patients receiving unfractioned heparin, HIT can also arise after low-molecular-weight heparin (LMWH). We report a case of HIT in a postoperative orth...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Mumoli N,Cei M

    更新日期:2010-02-01 00:00:00

  • Smoking status on outcomes after percutaneous coronary intervention.

    abstract:BACKGROUND:The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking. HYPOTHESIS:Smoking cessation or reductions could reduce the risk of adverse outcomes in patient after PCI. METH...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Chen T,Li W,Wang Y,Xu B,Guo J

    更新日期:2012-09-01 00:00:00

  • The inaccuracy of aortic valve systolic flutter as a screening test for significant aortic stenosis.

    abstract::The noninvasive assessment of the severity of aortic stenosis is difficult. A recent description of systolic flutter of aortic valve leaflets as a screening test for severe aortic stenosis was applied to a group of patients who had undergone catheterization. As opposed to the previous report, we found this an inaccura...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Vacek JL,Phelix J,Rycyna JL

    更新日期:1984-04-01 00:00:00

  • Mitral valve prolapse and partial syndactyly of the hands.

    abstract::A patient is presented who has mitral valve prolapse and syndactyly of the hands. This combination of findings has not been previously reported, but is consistent with one theory of the development of mitral valve prolapse. ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Fitzharris JW

    更新日期:1982-03-01 00:00:00

  • Improvement of exercise capacity after nifedipine in patients with Eisenmenger syndrome complicating ventricular septal defect.

    abstract::We investigated the potential benefit of a preferential pulmonary vasodilatory effect of nifedipine in 4 patients with Eisenmenger syndrome complicating ventricular septal defect. First-pass radionuclide scan was performed at rest to measure intracardiac shunting before and after nifedipine. Two hours after 20 mg subl...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章


    authors: Wong CK,Yeung DW,Lau CP,Cheng CH,Leung WH

    更新日期:1991-12-01 00:00:00

  • Acute changes in left ventricular diastolic function: cigarette smoking versus nicotine gum.

    abstract:BACKGROUND:Echocardiographic evidence of diastolic dysfunction has been demonstrated during acute cigarette smoking in patients with coronary artery disease. Similar studies in healthy patients have shown conflicting results. Furthermore, it is unclear whether nicotine or some other cigarette-related substance is respo...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Gembala MI,Ghanem F,Mann CA,Sorrell VL

    更新日期:2006-02-01 00:00:00

  • Independent effects of body fat and inflammatory markers on ventricular geometry, midwall function, and atrial remodeling.

    abstract:BACKGROUND:The effect of body fat distribution on left ventricular (LV) mass and geometry has been recently recognized. However, data regarding circulating inflammatory markers in relation to regional visceral fat deposits, which are metabolically active tissues that can impact cardiac structural remodeling, remain spa...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Lai YH,Liu CC,Kuo JY,Hung TC,Wu YJ,Yeh HI,Bulwer BE,Hung CL

    更新日期:2014-03-01 00:00:00

  • Safety and potential cost savings of same-setting electrophysiologic testing and placement of transvenous implantable cardioverter-defibrillators.

    abstract:BACKGROUND:Separately, electrophysiologic study (EPS) and placement of a transvenous implantable cardioverter-defibrillator (ICD) can be performed safely in the majority of patients. The safety and potential cost savings of same-setting procedures have not been evaluated. HYPOTHESIS:Electrophysiologic study and placem...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Pires LA,Ravi S,Lal VR,Kahlon JP

    更新日期:2001-09-01 00:00:00

  • A point-by-point response to recent arguments against the use of statins in primary prevention: this statement is endorsed by the American Society for Preventive Cardiology.

    abstract::Recently, a debate over the merits of statin therapy in primary prevention was published in the Wall Street Journal. The statin opponent claimed that statins should only be used in secondary prevention and never in any primary-prevention patients at risk for cardiovascular events. In this evidence-based rebuttal to th...

    journal_title:Clinical cardiology

    pub_type: 社论,评审


    authors: Joshi PH,Chaudhari S,Blaha MJ,Jones SR,Martin SS,Post WS,Cannon CP,Fonarow GC,Wong ND,Amsterdam E,Hirshfeld JW,Blumenthal RS

    更新日期:2012-01-01 00:00:00

  • Twenty-four-hour ambulatory oxygen desaturation and electrocardiographic recording in obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Although nocturnal pulseoximetry is routinely performed in obstructive sleep apnea syndrome (OSAS), pulseoximetry over a 24-h period has not been studied. HYPOTHESIS:The purpose of the study was to determine whether simultaneous 24-h oxygen desaturation and electrocardiographic (ECG) recording might be used...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Noda A,Ito R,Okada T,Yasuma F,Nakashima N,Yokota M

    更新日期:1998-07-01 00:00:00

  • Lifestyle change and high-density lipoprotein change: the US Department of Veterans Affairs Normative Aging Study.

    abstract:BACKGROUND:We sought to determine whether lifestyle modifications are associated with high-density lipoprotein cholesterol (HDL-C) change in a cohort with long-term follow-up. HYPOTHESIS:Changes in alcohol consumption, smoking, or body mass index (BMI) are associated with within-individual changes in HDL-C. METHODS:W...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Rahilly-Tierney C,Vokonas P,Gaziano JM,Spiro A 3rd

    更新日期:2012-01-01 00:00:00

  • Prognosis of large, symptomatic pericardial effusion treated by echo-guided percutaneous pericardiocentesis.

    abstract:BACKGROUNDS:The causes and prognosis of pericardial effusion (PE) may be different according to time, region, economy, and hospital. This study was performed to evaluate the etiology, clinical outcome, and prognosis of patients with large, symptomatic PE treated by echo-guided pericardiocentesis at Kangnam St. Mary's H...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Kil UH,Jung HO,Koh YS,Park HJ,Park CS,Kim PJ,Baek SH,Seung KB,Choi KB

    更新日期:2008-11-01 00:00:00

  • Systolic blood pressure and subjective well-being in patients with coronary artery disease.

    abstract:BACKGROUND:Limited information exists regarding the association between subjective well-being (SWB) and systolic blood pressure (SBP) among hypertensive patients with coronary artery disease (CAD). HYPOTHESIS:We tested the hypothesis that there is an association between SBP and SWB. METHODS:We studied 22,576 hyperten...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gong Y,Handberg EM,Gerhard T,Cooper-Dehoff RM,Ried LD,Johnson JA,Pepine CJ,INVEST Investigators.

    更新日期:2009-11-01 00:00:00

  • Coronary flow slows as renal function worsens.

    abstract:BACKGROUND:Slow coronary flow in patients without obstructive coronary artery disease is an angiographic finding that could easily be detected by thrombolysis in myocardial infarction (TIMI) frame counts. On the other hand, impaired renal function is a frequent problem. We searched the association between the 2 entitie...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Yilmaz MB,Yalta K

    更新日期:2009-05-01 00:00:00

  • Effect of balloon inflation-induced acute ischemia on QT dispersion during percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:QT dispersion (QTd = QTmax-QTmin) measured as interlead variability of QT interval reflects the spatial inhomogeneity of ventricular repolarization times, and increased QTd may provide a substrate for malignant ventricular arrhythmias. Ischemia is associated with regional abnormalities of conduction and repo...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Aytemir K,Bavafa V,Ozer N,Aksoyek S,Oto A,Ozmen F

    更新日期:1999-01-01 00:00:00

  • Effects on infarct size and left ventricular function of early intravenous injection of anistreplase in acute myocardial infarction. The APSIM Study Investigators.

    abstract::A total of 231 patients suffering from a first acute myocardial infarction were randomly allocated within 4 hours following the onset of symptoms either to anistreplase or anisoylated plasminogen streptokinase activator complex (APSAC), 30 U over 5 minutes, or to conventional heparin therapy, 5000 IU in bolus injectio...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Bassand JP,Bernard Y,Lusson JR,Machecourt J,Cassagnes J,Borel E

    更新日期:1990-03-01 00:00:00

  • Heart involvement in metastatic carcinoid disease.

    abstract::Sixteen patients with metastatic carcinoid tumors of ileal or cecal origin were studied in order to evaluate the frequency and degree of cardiac involvement in a nonselected patient group. We have also studied the correlation between plasma hormone levels (e.g., 5-hydroxytryptamine (5-HT) and substance P) and the degr...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Törnebrandt K,Eskilsson J,Nobin A

    更新日期:1986-01-01 00:00:00

  • Noninvasive evaluation of left ventricular performance by the shortest distance between mitral leaflets coaptation and interventricular septum at end-systole.

    abstract::We attempted to evaluate left ventricular performance from the shortest distance between the mitral leaflets coaptation and the interventricular septum at end-systole (MVC-IVS distance). The subjects were 37 patients with coronary artery disease (CAD) with prior myocardial infarction (MI), 8 with CAD without prior MI,...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Ohte N,Narita H,Hashimoto T,Takase R,Kobayashi K,Akita S,Fujinami T

    更新日期:1992-09-01 00:00:00

  • Dose-ranging study with a new two-chain rt-PA in patients with acute myocardial infarction: a multicenter trial.

    abstract::Tissue-type plasminogen activator (t-PA) derived from a melanoma cell line was first used in patients with acute myocardial infarction in the early 1980s. Recombinant DNA technology then allowed production of large amounts of t-PA. The TIMI-I trial used a two-chain recombinant (rt-PA) product. A predominantly single-c...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: DeWood MA,Kurnik PB,Jolly MK,Jain AC,Khaja F,Gorfinkel HJ,Morris DL,Satler L,LittleJohn J

    更新日期:1993-04-01 00:00:00

  • Rationale and design of the Henry Ford Exercise Testing Project (the FIT project).

    abstract::Although physical fitness is a powerful prognostic marker in clinical medicine, most cardiovascular population-based studies do not have a direct measurement of cardiorespiratory fitness. In line with the call from the National Heart Lung and Blood Institute for innovative, low-cost, epidemiologic studies leveraging e...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Al-Mallah MH,Keteyian SJ,Brawner CA,Whelton S,Blaha MJ

    更新日期:2014-08-01 00:00:00

  • Systolic, diastolic, and pulse pressures as coronary risk factors in a population with low cholesterol levels: a prospective 10-year evaluation.

    abstract:BACKGROUND:Pulse pressure (PP) has recently been found to be predictive of subsequent cardiovascular, particularly coronary, events in some middle-aged and elderly populations. HYPOTHESIS:The aim of this prospective population-based study was to evaluate the roles of systolic (SBP), diastolic blood pressure (DBP), and...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Onat A,Ceyhan K,Erer B,Başar O,Uysal O,Sansoy V

    更新日期:2003-02-01 00:00:00

  • The association of QRS duration with atrial fibrillation in a heart failure with preserved ejection fraction population: a pilot study.

    abstract:BACKGROUND:Heart failure is a significant cause of morbidity and mortality, yet patient risk stratification may be difficult. Prevention or treatment of atrial fibrillation (AF) may be an important strategy in these patients that could positively affect their outcome. It has been demonstrated that in patients with syst...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Gigliotti JN,Sidhu MS,Robert AM,Zipursky JS,Brown JR,Costa SP,Palac RT,Steckman DA,Malenka DJ,Kono AT,Greenberg ML

    更新日期:2017-10-01 00:00:00

  • Hemodynamics and myocardial oxygen metabolism of pulsus alternans in patients with dilative cardiomyopathy.

    abstract::The hemodynamic and myocardial energetic changes due to pulsus alternans were investigated by left and right heart catheterization and by oxygen consumption measurements in three patients with dilative cardiomyopathy. In all three patients, pulsus alternans developed after intravenous administration of the phosphodies...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Hasenfuss G,Holubarsch C,Heiss HW,Bonzel T,Funfack M,Revenaugh M,Meinertz T,Just H

    更新日期:1987-05-01 00:00:00

  • Late thrombotic obstruction of an aortic bioprosthetic valve: successful treatment by oral anticoagulation.

    abstract::Thrombotic obstruction of aortic bioprostheses is rare. Few cases have been reported involving the use of the Carpentier-Edwards (CE) prosthesis, the Hancock bioprosthesis, or the Medtronic Intact porcine valve. Thrombolytic therapy for mechanical valve thrombosis has been used frequently even though it is known to ca...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Juliard JM,Paillole C,Dahan M,Steg PG,Himbert D,Aumont MC

    更新日期:1993-02-01 00:00:00

  • Impact of tricuspid regurgitation and right ventricular dysfunction on outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis.

    abstract::Far less attention has been paid to the prognostic effect of right-side heart disease on outcomes after transcatheter aortic valve replacement (TAVR) when compared with the left side. Therefore, we performed a systematic review and meta-analysis on the impact of tricuspid regurgitation (TR) and right ventricular (RV) ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,meta分析


    authors: Fan J,Liu X,Yu L,Sun Y,Jaiswal S,Zhu Q,Chen H,He Y,Wang L,Ren K,Wang J

    更新日期:2019-01-01 00:00:00

  • The anti-ischemic potential of angiotensin-converting enzyme inhibition: insights from the heart outcomes prevention evaluation trial.

    abstract::Therapy with an angiotensin-converting enzyme (ACE) inhibitor is established for reducing excessive blood pressure, reducing mortality in patients with congestive heart failure (CHF), preventing the development of CHF in patients with asymptomatic left ventricular (LV) dysfunction, and preventing death and CHF when in...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审


    authors: Pitt B

    更新日期:2000-07-01 00:00:00

  • Hypertrophic cardiomyopathy: two-dimensional echocardiographic score versus clinical and electrocardiographic findings.

    abstract::The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM). We evaluated left ventricular hypertrophy by means of two-dimensional echocardiographic score and score index, and correlated these findings with symptoms, electrovector-c...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Melacini P,Fasoli G,Canciani B,Buja G,Mammola C,Volta SD

    更新日期:1989-08-01 00:00:00

  • Relation of body fluid status to B-type natriuretic peptide levels in patients with chronic heart failure during long-term follow-up.

    abstract:BACKGROUND:Little is known about the relationship of body fluid status with the levels and fluctuations of B-type natriuretic peptide (BNP) over the long-term. HYPOTHESIS:If BNP is to become useful for monitoring of patients with chronic heart failure (HF), the levels should reliably reflect both decompensation and im...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Kataoka H

    更新日期:2006-10-01 00:00:00

  • Left ventricular mass assessed by three-dimensional echocardiography using rotational acquisition.

    abstract:BACKGROUND:The reproducibility of left ventricular (LV) mass measurement by two-dimensional (2-D) echocardiography is inadequate for individual assessments. HYPOTHESIS:This study was undertaken to evaluate the potential of LV mass determination with a new three-dimensional (3-D) echocardiographic method compared with ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Rodevand O,Bjornerheim R,Kolbjornsen O,Ihlen H,Kjekshus J

    更新日期:1997-11-01 00:00:00