Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: critical influence of the drug introduction mode on the in vitro cement properties.

abstract：:Creating micro/nanostructured hydrogels with tunable morphologies under cell-friendly processing conditions would enable rational engineering of hydrogel scaffolds for targeted biomedical applications. Herein, an all-aqueous single-step reactive electrospinning method is applied to prepare hydrogel networks with contr...

journal_title：Acta biomaterialia

authors： Xu F,Gough I,Dorogin J,Sheardown H,Hoare T

更新日期：2020-03-01 00:00:00

abstract：UNLABELLED:We show with laboratory experiments that self-assembled mineral tube formation involving precipitation around a templating jet of fluid - a mechanism well-known in the physical sciences from the tubular growth of so-called chemical gardens - functions with carbonates, and we analyse the microstructures and c...

journal_title：Acta biomaterialia

authors： Cardoso SSS,Cartwright JHE,Checa AG,Sainz-Díaz CI

更新日期：2016-10-01 00:00:00

abstract：:Phosphate-based glass fibers (PGFs), due to characteristics such as biodegradability and directionality, could be effective as spatial cues for axonal outgrowth following nerve injury. In the present study, PGF-containing cylindrical scaffolds of 1.8mm diameter and 3mm length were developed and implanted into the gap ...

journal_title：Acta biomaterialia

authors： Joo NY,Knowles JC,Lee GS,Kim JW,Kim HW,Son YJ,Hyun JK

更新日期：2012-05-01 00:00:00

abstract：UNLABELLED:Rapid vascularization of bone graft substitutes upon implantation is one of the most important challenges to overcome in order to achieve successful regeneration of large, critical-size bone defects. One strategy for stimulating vascularization during the regeneration process is to create a hypoxic microenvi...

journal_title：Acta biomaterialia

authors： Tahmasebi Birgani Z,Fennema E,Gijbels MJ,de Boer J,van Blitterswijk CA,Habibovic P

更新日期：2016-05-01 00:00:00

abstract：:Since most antibacterial coatings reported to fight biomaterial-associated infections (BAI) fail in completely preventing bacterial colonization, it is crucial to know the impact of that small fraction of adhered bacteria in BAI recrudescence. This study aims to understand the fate of Staphylococcus aureus able to adh...

journal_title：Acta biomaterialia

authors： Alves DF,Magalhães AP,Neubauer D,Bauer M,Kamysz W,Pereira MO

更新日期：2018-09-15 00:00:00

abstract：:Polysaccharides with structure and potential bioactivity similar to heparin were synthesized based on cellulose which was regioselectively sulfated, carboxylated or carboxymethylated, and chitosan that was sulfated only. Osteogenic activity of these derivatives was studied in cooperation with BMP-2 using C2C12 myoblas...

journal_title：Acta biomaterialia

authors： Peschel D,Zhang K,Fischer S,Groth T

更新日期：2012-01-01 00:00:00

abstract：:Biomaterials made of biodegradable poly(α-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises wheth...

journal_title：Acta biomaterialia

authors： Hild N,Tawakoli PN,Halter JG,Sauer B,Buchalla W,Stark WJ,Mohn D

更新日期：2013-11-01 00:00:00

abstract：:Tissue engineering is an ideal therapeutic strategy for the development of functional tendon replacement tissue for tendon repair in the clinic. Currently, the synergistic roles of mechano-chemical factors and the mechanisms involved in tendon repair and regeneration are not fully understood. In this study, we develop...

journal_title：Acta biomaterialia

authors： Zhang B,Luo Q,Deng B,Morita Y,Ju Y,Song G

更新日期：2018-07-01 00:00:00

abstract：UNLABELLED:Natural amino acids are zwitterionic molecules and the good biocompatibility promises them potential candidates as anti-fouling materials. Here, we developed a new method to functionalize silica nanoparticles with a natural amino acid-based anti-fouling layer. Amino acids were covalently immobilized on 3-ami...

journal_title：Acta biomaterialia

authors： Wang H,Cheng F,Shen W,Cheng G,Zhao J,Peng W,Qu J

更新日期：2016-08-01 00:00:00

abstract：:Electrical stimulation of the muscle has been proven efficacious in preventing atrophy and/or reanimating paralyzed muscles. Intramuscular electrodes made from metals have significantly higher Young's Moduli than the muscle tissues, which has the potential to cause chronic inflammation and decrease device performance....

journal_title：Acta biomaterialia

authors： Zheng XS,Griffith AY,Chang E,Looker MJ,Fisher LE,Clapsaddle B,Cui XT

更新日期：2020-02-01 00:00:00

abstract：:Posterior capsular opacification (PCO) is the most common complication of cataract surgery. PCO is due to the proliferation, migration, and epithelial-to-mesenchymal transition of the residual lens epithelial cells (LECs) within the lens capsule. As surface topography influences cellular response, we investigated the ...

journal_title：Acta biomaterialia

authors： Seo Y,Kim S,Lee HS,Park J,Lee K,Jun I,Seo H,Kim YJ,Yoo Y,Choi BC,Seok HK,Kim YC,Ok MR,Choi J,Joo CK,Jeon H

更新日期：2020-10-15 00:00:00

abstract：:Novel porous bilayered scaffolds, fully integrating a silk fibroin (SF) layer and a silk-nano calcium phosphate (silk-nanoCaP) layer for osteochondral defect (OCD) regeneration, were developed. Homogeneous porosity distribution was achieved in the scaffolds, with calcium phosphate phase only retained in the silk-nanoC...

journal_title：Acta biomaterialia

authors： Yan LP,Silva-Correia J,Oliveira MB,Vilela C,Pereira H,Sousa RA,Mano JF,Oliveira AL,Oliveira JM,Reis RL

更新日期：2015-01-01 00:00:00

abstract：:The use of biodegradable beta-tricalcium phosphate (β-TCP) scaffolds holds great promise for bone tissue engineering. However, the effects of β-TCP on bone and endothelial cells are not fully understood. This study aimed to investigate cell proliferation and differentiation of mono- or co-cultured human-bone-marrow-de...

journal_title：Acta biomaterialia

authors： Kang Y,Kim S,Fahrenholtz M,Khademhosseini A,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:The titanium dioxide (TiO(2)) nanotube surface enables significantly accelerated osteoblast adhesion and exhibits strong bonding with bone. We prepared various sizes (30-100 nm diameter) of titanium dioxide (TiO(2)) nanotubes on titanium substrates by anodization and investigated the osteoblast cellular behavior in re...

journal_title：Acta biomaterialia

authors： Brammer KS,Oh S,Cobb CJ,Bjursten LM,van der Heyde H,Jin S

更新日期：2009-10-01 00:00:00

abstract：:Recapitulation of endochondral ossification leads to a new concept of bone tissue engineering via a cartilage intermediate as an osteoinductive template. In this study, we aimed to investigate the influence of in vitro chondrogenic priming time for the creation of cartilage template on the in vivo endochondral bone fo...

journal_title：Acta biomaterialia

authors： Yang W,Both SK,van Osch GJ,Wang Y,Jansen JA,Yang F

更新日期：2015-02-01 00:00:00

abstract：:The identification of a biologic substrate for maintaining hepatocyte functions is essential to provide reliable and predictable models for in vitro drug screening. In the current study, a three-dimensional culture of hepatocytes was established on highly porous fibrous scaffolds with grafted galactose and RGD to affo...

journal_title：Acta biomaterialia

authors： Yan S,Wei J,Liu Y,Zhang H,Chen J,Li X

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the biological properties of a collagen-phospholipid polymer hybrid gel (MiC30 gel) designed for use as a tissue membrane. The following four types of collagen gels were synthesized and tested in vitro and in vivo: physically cross-linked collagen gel (Uc gel), N-(3-dimethy...

journal_title：Acta biomaterialia

authors： Nam K,Kimura T,Funamoto S,Kishida A

更新日期：2010-02-01 00:00:00

abstract：:This study deals with cytotoxicity assays performed on an array of commercially manufactured inorganic nanoparticulate materials, including Ag, TiO(2), Fe(2)O(3), Al(2)O(3), ZrO(2), Si(3)N(4), naturally occurring mineral chrysotile asbestos and carbonaceous nanoparticulate materials such as multiwall carbon nanotube a...

journal_title：Acta biomaterialia

authors： Soto K,Garza KM,Murr LE

更新日期：2007-05-01 00:00:00

abstract：:The effects of a biphasic mineralized collagen scaffold (BCS) containing intrafibrillar silica and apatite on osteogenesis of mouse mesenchymal stem cells (mMSCs) and inhibition of receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclastogenesis were investigated in the present study. mMSCs were cult...

journal_title：Acta biomaterialia

authors： Jiao K,Niu LN,Li QH,Chen FM,Zhao W,Li JJ,Chen JH,Cutler CW,Pashley DH,Tay FR

更新日期：2015-06-01 00:00:00

abstract：:Biomaterial-mediated controlled release of soluble signaling molecules is a tissue engineering approach to spatially control processes of inflammation, microvascular remodeling and host cell recruitment, and to generate biochemical gradients in vivo. Lipid mediators, such as sphingosine 1-phosphate (S1P), are recogniz...

journal_title：Acta biomaterialia

authors： Ogle ME,Sefcik LS,Awojoodu AO,Chiappa NF,Lynch K,Peirce-Cottler S,Botchwey EA

更新日期：2014-11-01 00:00:00

abstract：:Bioabsorbable polymers are increasingly being used in tissue engineering strategies. Despite the knowledge that some sterilization techniques may affect the physical properties of these polymers, this aspect is often overlooked. We speculate that the type of sterilization method used may influence cellular responses b...

journal_title：Acta biomaterialia

authors： Kroeze RJ,Helder MN,Roos WH,Wuite GJ,Bank RA,Smit TH

更新日期：2010-06-01 00:00:00

abstract：:The objective of our study was to evaluate the influence of prolonged artificial ageing on oxidation resistance and the subsequent wear behaviour of vitamin E-stabilized, in comparison to standard and highly cross-linked remelted polyethylene (XLPE), and the degradation effect of third-body particles on highly cross-l...

journal_title：Acta biomaterialia

authors： Grupp TM,Holderied M,Mulliez MA,Streller R,Jäger M,Blömer W,Utzschneider S

更新日期：2014-07-01 00:00:00

abstract：:Spherical bioactive glass 13-93 particles, with a particle size distribution of 50-125 microm, were combined with bioabsorbable poly-L,DL-lactide 70/30 using twin-screw extrusion. The composite rods containing 0, 20, 30, 40 and 50 wt% of bioactive glass were further self-reinforced by drawing to a diameter of approxim...

journal_title：Acta biomaterialia

authors： Niemelä T,Niiranen H,Kellomäki M,Törmälä P

更新日期：2005-03-01 00:00:00

abstract：UNLABELLED:With improvements in oral health and an overall increase in quality of life, the percentage of fully or largely dentate seniors is increasing. Understanding the effects of aging on the mechanical properties of teeth is essential to the maintenance of lifelong oral health. In this investigation the effects of...

journal_title：Acta biomaterialia

authors： Yahyazadehfar M,Zhang D,Arola D

更新日期：2016-03-01 00:00:00

abstract：:Biomolecular signals within the native extracellular matrix are complex, with bioactive factors found in both soluble and sequestered states. In the design of biomaterials for tissue engineering applications it is increasingly clear that new approaches are required to locally tailor the biomolecular environment surrou...

journal_title：Acta biomaterialia

authors： Alsop AT,Pence JC,Weisgerber DW,Harley BAC,Bailey RC

更新日期：2014-11-01 00:00:00

abstract：:A novel visible light-crosslinkable porcine gelatin was prepared for gelation and micropatterning. The preparation employed a photo-oxidation-induced crosslinking mechanism. First, furfuryl groups were incorporated into the gelatin. Second, the modified gelatin was mixed in water with Rose Bengal, which is a visible l...

journal_title：Acta biomaterialia

authors： Son TI,Sakuragi M,Takahashi S,Obuse S,Kang J,Fujishiro M,Matsushita H,Gong J,Shimizu S,Tajima Y,Yoshida Y,Suzuki K,Yamamoto T,Nakamura M,Ito Y

更新日期：2010-10-01 00:00:00

abstract：:Using novel nitric oxide (NO)-generating polymeric hydrogels that can be rapidly photopolymerized in situ, we can deliver NO locally at the site of vascular injury. Depending on material design, these poly(ethylene glycol) (PEG)-based hydrogels can generate NO for up to 50 d. This study demonstrates the ability of nit...

journal_title：Acta biomaterialia

authors： Lipke EA,West JL

更新日期：2005-11-01 00:00:00

abstract：:The active and passive mechanical behavior of a cosmetic tightening product for skin anti-aging is investigated based on a wide range of in vivo and in vitro measurements. The experimental data are used to inform a numerical model of the attained cosmetic effect, which is then implemented in a commercial finite-elemen...

journal_title：Acta biomaterialia

authors： Pensalfini M,Rotach M,Hopf R,Bielicki A,Santoprete R,Mazza E

更新日期：2020-10-01 00:00:00

abstract：:One of the challenges of using bioactive bone cements is adjusting their handling properties for clinical application. To resolve the poorer handling properties of bioactive bone cements we developed a novel bioactive bone cement containing a unique polymethylmethacrylate (PMMA) powder, termed SPD-PMMA (40 μm in diame...

journal_title：Acta biomaterialia

authors： Fukuda C,Goto K,Imamura M,Neo M,Nakamura T

更新日期：2011-10-01 00:00:00

abstract：:The physical and mechanical properties of structural proteins such as silk fibroin can be modified by controlled conformational change, which is regularly monitored by Fourier transform infrared spectroscopy by peak fitting of the amide I band envelope. Although many variables affecting peak shape are well established...

journal_title：Acta biomaterialia

authors： Belton DJ,Plowright R,Kaplan DL,Perry CC

更新日期：2018-06-01 00:00:00