Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance.

abstract：:Engineered three-dimensional biomaterials are known to affect the regenerative capacity of stem cells. The extent to which these materials can modify cellular activities is still poorly understood, particularly for adipose-derived stem cells (ASCs). This study evaluates PEGylated fibrin (P-fibrin) gels as an ASC-carry...

journal_title：Acta biomaterialia

authors： Chung E,Rytlewski JA,Merchant AG,Dhada KS,Lewis EW,Suggs LJ

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:In order to create tissue-engineered heart valves with long-term functionality, it is essential to fully understand collagen remodeling during neo-tissue formation. Collagen remodeling is thought to maintain mechanical tissue homeostasis. Yet, the driving factor of collagen remodeling remains unidentified. I...

journal_title：Acta biomaterialia

authors： Oomen PJA,Loerakker S,van Geemen D,Neggers J,Goumans MTH,van den Bogaerdt AJ,Bogers AJJC,Bouten CVC,Baaijens FPT

更新日期：2016-01-01 00:00:00

abstract：:Lysosomal entrapment and liver accumulation are the two main obstacles faced by many anticancer drugs for achieving satisfactory therapeutic outcomes. Here, we develop a facile one-step hydrothermal synthetic route to prepare trace metal (M)-, N-, and O-doped carbon-dominated nanoparticles (termed as MNOCNPs, M = Ni, ...

journal_title：Acta biomaterialia

authors： Bao YW,Hua XW,Li YH,Jia HR,Wu FG

更新日期：2019-04-01 00:00:00

abstract：:Synthetic polymer microarray technology holds remarkable promise to rapidly identify suitable biomaterials for stem cell and tissue engineering applications. However, most of previous microarrayed synthetic polymers do not possess biological ligands (e.g., peptides) to directly engage cell surface receptors. Here, we ...

journal_title：Acta biomaterialia

authors： Jia J,Coyle RC,Richards DJ,Berry CL,Barrs RW,Biggs J,James Chou C,Trusk TC,Mei Y

更新日期：2016-11-01 00:00:00

abstract：:In order to improve the osseointegration and long-term survival of dental implants, it is urgent to develop a multifunctional titanium surface which would simultaneously have osteogeneic, angiogeneic and antibacterial properties. In this study, a potential dental implant material-dual Zn/Mg ion co-implanted titanium (...

journal_title：Acta biomaterialia

authors： Yu Y,Jin G,Xue Y,Wang D,Liu X,Sun J

更新日期：2017-02-01 00:00:00

abstract：:For spinal-fixation applications, implants should have a high Young's modulus to reduce springback during operations, though a low Young's modulus is required to prevent stress shielding for patients after surgeries. In the present study, Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) with a low Young's modulus was modified by addin...

journal_title：Acta biomaterialia

authors： Li Q,Niinomi M,Hieda J,Nakai M,Cho K

更新日期：2013-08-01 00:00:00

abstract：:The majority of in vitro studies assessing cancer treatments are performed in two-dimensional (2D) monolayers and are subsequently validated in in vivo animal models. However, 2D models fail to accurately model the tumour microenvironment. Furthermore, animal models are not directly applicable to mimic the human scena...

journal_title：Acta biomaterialia

authors： Costard LS,Hosn RR,Ramanayake H,O'Briena B C FJ,Curtin CM

更新日期：2021-01-20 00:00:00

abstract：:Tissue-engineered constructs can be fabricated by the assembly of smaller building blocks in order to mimic much of the native biology that is often made from repeating functional units. Our aim was to realize a three-dimensional (3-D) tissue-like construct in vitro by inducing the assembly of functional micrometric t...

journal_title：Acta biomaterialia

authors： Palmiero C,Imparato G,Urciuolo F,Netti P

更新日期：2010-07-01 00:00:00

abstract：:The effects of the microstructures and phases of Zr-rich Mo alloys on their magnetic susceptibilities and mechanical properties were investigated in order to develop a Zr alloy with low magnetic susceptibility for use in magnetic resonance imaging (MRI). The magnetic susceptibility was measured with a magnetic suscept...

journal_title：Acta biomaterialia

authors： Suyalatu,Kondo R,Tsutsumi Y,Doi H,Nomura N,Hanawa T

更新日期：2011-12-01 00:00:00

abstract：:Antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. This study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (CVCES) of -1.5V and -1.8V (vs. Ag/AgCl) to coupons of commercially pure titanium (cpTi) incubat...

journal_title：Acta biomaterialia

authors： Canty M,Luke-Marshall N,Campagnari A,Ehrensberger M

更新日期：2017-01-15 00:00:00

abstract：:Three-dimensional (3D) porous zinc (Zn) with a moderate degradation rate is a promising candidate for biodegradable bone scaffolds. However, fabrication of such scaffolds with adequate mechanical properties remains a challenge. Moreover, the composition, crystallography and microstructure of the in vivo degradation pr...

journal_title：Acta biomaterialia

authors： He J,Fang J,Wei P,Li Y,Guo H,Mei Q,Ren F

更新日期：2021-02-01 00:00:00

abstract：:In the present study, the density functional theory implemented in the Vienna Ab-initio Simulation Package has been used to investigate the alloying effects of different elements of calcium, zinc, yttrium, aluminum and iron when introduced in the Mg crystal lattice. In particular, studies have been conducted to invest...

journal_title：Acta biomaterialia

authors： Velikokhatnyi OI,Kumta PN

更新日期：2010-05-01 00:00:00

abstract：:Poly(ethylene glycol) (PEG) can be functionalized and modified with various moieties allowing for a multitude of cross-linking chemistries. Here, we investigate how vinyl sulfone, acrylate, and maleimide functional end groups affect hydrogel formation, physical properties, viability of encapsulated cells, post-polymer...

journal_title：Acta biomaterialia

authors： Day JR,David A,Kim J,Farkash EA,Cascalho M,Milašinović N,Shikanov A

更新日期：2018-02-01 00:00:00

abstract：:In this study a novel kind of porous poly(l-glutamic acid) (PLGA)/chitosan polyelectrolyte complex (PEC) microsphere was developed through electrostatic interaction between PLGA and chitosan. By adjusting the formula parameters chitosan microspheres with an average pore size of 47.5 ± 5.4 μm were first developed at a ...

journal_title：Acta biomaterialia

authors： Fang J,Zhang Y,Yan S,Liu Z,He S,Cui L,Yin J

更新日期：2014-01-01 00:00:00

abstract：:Corneal collagen cross-linking (CXL) treatment can restore vision in patients suffering from keratoconus and corneal injury, by improving the mechanical properties of the cornea. The correlation between ultraviolet-A (UVA) irradiant energies of standard CXL (SCXL) and corneal visco-hyperelastic mechanical behavior rem...

journal_title：Acta biomaterialia

authors： Liu T,Shen M,Li H,Zhang Y,Mu B,Zhao X,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:A series of Sr-substituted hydroxyapatites, (Sr(x)Ca(1-)(x))(5)(PO(4))(3)OH, where x=0.00, 0.25, 0.50, 0.75 and 1.00, were made by a standard wet chemical route and investigated using X-ray diffraction (XRD), Rietveld refinement and Raman spectroscopy. We report apatites manufactured by two synthesis routes under 90 d...

journal_title：Acta biomaterialia

authors： O'Donnell MD,Fredholm Y,de Rouffignac A,Hill RG

更新日期：2008-09-01 00:00:00

abstract：:Calcium phosphate based bioceramics have been widely used for orthopedic applications due to their chemical similarity to natural bone. The Ca/P stoichiometry of calcium phosphates strongly influences their performance under biological conditions, which have not yet been fully elucidated to date. For this reason, the ...

journal_title：Acta biomaterialia

authors： Liu H,Yazici H,Ergun C,Webster TJ,Bermek H

更新日期：2008-09-01 00:00:00

abstract：:The main aim of this review study was to report the state of art on the nano-scale technological advancements of titanium implant surfaces to enhance the osseointegration process. Several methods of surface modification are chronologically described bridging ordinary methods (e.g. grit blasting and etching) and advanc...

journal_title：Acta biomaterialia

authors： Souza JCM,Sordi MB,Kanazawa M,Ravindran S,Henriques B,Silva FS,Aparicio C,Cooper LF

更新日期：2019-08-01 00:00:00

abstract：:Tumour microenvironment (TME)-targeting nanoparticles (NPs) were developed based on Methanococcus jannaschii small heat shock proteins (Mj-sHSPs). Transactivator of transcription (TAT) were modified on the surface of Mj-sHSPs (T-HSPs) to enhance their cellular internalization ability (CIA), and a pH/enzyme dual sensit...

journal_title：Acta biomaterialia

authors： Shi K,Wang Y,Zhou X,Gui H,Xu N,Wu S,He C,Zhao Z

更新日期：2020-09-15 00:00:00

abstract：UNLABELLED:Humans make high levels of antibody to carbohydrates with terminal galactose α 1,3 galactose (Gal) modifications. This Gal antigen is widely expressed in other mammals and is present on an array of current animal derived biomedical devices including bioprosthetic heart valves. There is growing interest in us...

journal_title：Acta biomaterialia

authors： McGregor C,Byrne G,Rahmani B,Chisari E,Kyriakopoulou K,Burriesci G

更新日期：2016-09-01 00:00:00

abstract：:Decellularized heart valves have great potential as a stand-alone valve replacement or as a scaffold for tissue engineering heart valves. Before decellularized valves can be widely used clinically, regulatory standards require pre-clinical testing in an animal model, often sheep. Numerous decellularization protocols h...

journal_title：Acta biomaterialia

authors： VeDepo MC,Buse EE,Quinn RW,Williams TD,Detamore MS,Hopkins RA,Converse GL

更新日期：2017-03-01 00:00:00

abstract：:Recent biotechnological progress has enabled the production of spider silk proteins, spidroins, in heterologous hosts. Matrices based on recombinant spidroins support stem cell growth and are well tolerated when implanted in living tissue, thus the material is highly attractive for use in regenerative medicine. Howeve...

journal_title：Acta biomaterialia

authors： Rising A

更新日期：2014-04-01 00:00:00

abstract：:A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surf...

journal_title：Acta biomaterialia

authors： Miao S,Cheng K,Weng W,Du P,Shen G,Han G,Yan W,Zhang S

更新日期：2008-03-01 00:00:00

abstract：:Molecular traps can control activity and abundance of many biological factors. Here, we report the development of a generic opto-trap to reversibly bind and release biomolecules with high spatiotemporal control by illumination with non-invasive and cell-compatible red and far-red light. We use the Arapidopsis thaliana...

journal_title：Acta biomaterialia

authors： Beyer HM,Thomas OS,Riegel N,Zurbriggen MD,Weber W,Hörner M

更新日期：2018-10-01 00:00:00

abstract：:Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...

journal_title：Acta biomaterialia

authors： Zhang F,Jia Y,Zheng X,Shao D,Zhao Y,Wang Z,Dawulieti J,Liu W,Sun M,Sun W,Pan Y,Cui L,Wang Y,He K,Zhang M,Li J,Dong WF,Chen L

更新日期：2019-12-01 00:00:00

abstract：:Ultra-high molecular weight polyethylene (UHMWPE) is frequently employed in joint replacements because of its high biocompatibility; however, this material does not exhibit particularly strong wear performance, thus potentially reducing the longevity of such devices. Numerous techniques have been investigated to incre...

journal_title：Acta biomaterialia

authors： Perni S,Kong MG,Prokopovich P

更新日期：2012-03-01 00:00:00

abstract：:Slow protein release from amyloidal materials is a molecular platform used by nature to control protein hormone secretion in the endocrine system. The molecular mechanics of the sustained protein release from amyloids remains essentially unexplored. Inclusion bodies (IBs) are natural amyloids that occur as discrete pr...

journal_title：Acta biomaterialia

authors： Cano-Garrido O,Rodríguez-Carmona E,Díez-Gil C,Vázquez E,Elizondo E,Cubarsi R,Seras-Franzoso J,Corchero JL,Rinas U,Ratera I,Ventosa N,Veciana J,Villaverde A,García-Fruitós E

更新日期：2013-04-01 00:00:00

abstract：:Surgical meshes are effective and frequently used to reinforce soft tissues. Fibrin glue (FG) has been widely used for mesh fixation and is also considered an optimal vehicle for stem cell delivery. The aim of this preclinical study was to evaluate the therapeutic effect of MSCs and their exosomes combined with FG for...

journal_title：Acta biomaterialia

authors： Blázquez R,Sánchez-Margallo FM,Álvarez V,Usón A,Marinaro F,Casado JG

更新日期：2018-04-15 00:00:00

abstract：:Cationic polymer-based vectors have been considered a promising strategy in gene therapy area due to their inherent ability to condense genetic material and successfully transfect cells. However, they usually exhibit high cytotoxicity. In this work, it is proposed the use of a tailor-made gene carrier based on a tri-b...

journal_title：Acta biomaterialia

authors： Cordeiro RA,Santo D,Farinha D,Serra A,Faneca H,Coelho JFJ

更新日期：2017-01-01 00:00:00

abstract：:Synthesis of tissue adhesives had been carried out in various laboratories in the past decades but the development is currently stalled. One of the key reasons, it is believed, is that researchers have not fully understood and resolved the role of the functional groups that are responsible for good adhesion to biologi...

journal_title：Acta biomaterialia

authors： Lim KP,Tan LP

更新日期：2009-01-01 00:00:00