Abstract:
:Bioabsorbable polymers are increasingly being used in tissue engineering strategies. Despite the knowledge that some sterilization techniques may affect the physical properties of these polymers, this aspect is often overlooked. We speculate that the type of sterilization method used may influence cellular responses by altering the surface characteristics. We cultured adipose stem cells on bioabsorbable poly(l-lactide-co-caprolactone) (PLCL) sheets, sterilized using either ethylene oxide (EO), argon glow discharge (aGD) or electron beam (e-beam). Significantly higher values for surface roughness in the order EO>aGD>e-beam and significant differences in contact angles (EO>e-beam>aGD) and surface energies (aGD>e-beam>EO) were observed. Increased cell attachment and proliferation rates were observed with lower contact angles. The alkaline phosphatase activity was significantly higher for the ethylene oxide sterilized PLCL sheet. In conclusion, the type of sterilization for bioabsorbable polymers should be considered in the design of new scaffolds, since it might affect, or can be used to enhance, the outcome of the tissue engineered construct.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Kroeze RJ,Helder MN,Roos WH,Wuite GJ,Bank RA,Smit THdoi
10.1016/j.actbio.2009.11.022subject
Has Abstractpub_date
2010-06-01 00:00:00pages
2060-5issue
6eissn
1742-7061issn
1878-7568pii
S1742-7061(09)00518-2journal_volume
6pub_type
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