Reliability of the porphobilinogen screening assay.

Abstract:

:A survey conducted by the Australian Association of Clinical Biochemists Porphyrin Working Party on urinary porphobilinogen screening showed good sensitivity (75-97.5%). This is contrary to reports in the literature and to our own observations. We therefore assessed a widely used screening method (Watson-Schwartz) and found poor sensitivity (40-69%), and even less sensitivity (28-53%) when the urine samples were normally coloured or concentrated. Thus the results obtained by the Working Party might mislead one to infer that the Watson-Schwartz method is reliable.

journal_name

Pathology

journal_title

Pathology

authors

Buttery JE,Carrera AM,Pannall PR

doi

10.3109/00313029009086660

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

197-8

issue

4

eissn

0031-3025

issn

1465-3931

journal_volume

22

pub_type

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