Breakthrough Hormographiella aspergillata infections arising in neutropenic patients treated empirically with caspofungin.

Abstract:

:Hormographiella aspergillata, a filamentous basidiomycete, has rarely been involved in human infections. We describe 2 febrile neutropenic patients who developed a severe pulmonary infection due to H. aspergillata while receiving empirical caspofungin therapy for presumed fungal pneumonia. After introduction of liposomal amphotericin B, one patient, who had neutrophil recovery, presented a favorable outcome, while the other, who remained neutropenic throughout the course of infection, died. Resistant fungi, including basidiomycetes, may emerge during empirical treatment with caspofungin in febrile neutropenic patients. A rapid switch to any other potent antifungal should be rapidly considered in case of failure of caspofungin in this setting.

journal_name

J Clin Microbiol

authors

Suarez F,Olivier G,Garcia-Hermoso D,Randriamalala E,Ghez D,Bruneau J,Kauffmann-Lacroix C,Bougnoux ME,Lortholary O

doi

10.1128/JCM.01213-10

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

461-5

issue

1

eissn

0095-1137

issn

1098-660X

pii

JCM.01213-10

journal_volume

49

pub_type

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