Abstract:
:Fear conditioning and extinction serve as a dominant model for the development and maintenance of pathological anxiety, particularly for phasic fear to specific stimuli or situations. The validity of this model would be supported by differences in the physiological or subjective fear response between patients with fear-related disorders and healthy controls, whereas the model's validity would be questioned by a lack of such differences. We derived pupillometry, skin conductance response and startle electromyography as well as unconditioned stimulus expectancy in a two-day fear acquisition, immediate extinction and recall task and compared an unmedicated group of patients (n = 73) with phobias or panic disorder and a group of patients with posttraumatic stress disorder (PTSD, n = 21) to a group of carefully screened healthy controls (n = 35). Bayesian statistics showed no convincing evidence for a difference in physiological and subjective responses between the groups during fear acquisition, extinction learning or recall. Only the PTSD subgroup had altered startle reactions during extinction learning. Our data do not provide evidence for general differences in associative fear or extinction learning in fear-related pathologies and thereby question the diagnostic validity of the associative fear learning model of these disorders.
journal_name
Behav Res Therjournal_title
Behaviour research and therapyauthors
Pöhlchen D,Leuchs L,Binder FP,Blaskovich B,Nantawisarakul T,Topalidis P,Brückl TM,Norrholm SD,Jovanovic T,BeCOME working group.,Spoormaker VIdoi
10.1016/j.brat.2020.103610subject
Has Abstractpub_date
2020-06-01 00:00:00pages
103610eissn
0005-7967issn
1873-622Xpii
S0005-7967(20)30061-9journal_volume
129pub_type
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journal_title:Behaviour research and therapy
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